AVEED (TESTOSTERONE UNDECANOATE)
- Androgen deficiency
- Gonadotropin releasing factor deficiency
- Male hypogonadism
- Bilateral anorchia
- Bilateral orchiectomy
- Chemotherapy-induced hypogonadism
- Cryptorchidism
- Klinefelter's syndrome
- Primary hypogonadism due to bilateral torsion of testes
- Primary hypogonadism due to orchitis
750 mg/3 mL (250mg/mL) intramuscular solution
- Inject 3 milliliters (750 mg) by intramuscular route every 10 weeks
Androgen deficiency
- Inject 3 milliliters (750 mg) by intramuscular route every 10 weeks
Bilateral anorchia
- Inject 3 milliliters (750 mg) by intramuscular route every 10 weeks
Bilateral orchiectomy
- Inject 3 milliliters (750 mg) by intramuscular route every 10 weeks
Chemotherapy-induced hypogonadism
- Inject 3 milliliters (750 mg) by intramuscular route every 10 weeks
Cryptorchidism
- Inject 3 milliliters (750 mg) by intramuscular route every 10 weeks
Gonadotropin releasing factor deficiency
- Inject 3 milliliters (750 mg) by intramuscular route every 10 weeks
Klinefelter's syndrome
- Inject 3 milliliters (750 mg) by intramuscular route every 10 weeks
Male hypogonadism
- Inject 3 milliliters (750 mg) by intramuscular route every 10 weeks
Primary hypogonadism due to bilateral torsion of testes
- Inject 3 milliliters (750 mg) by intramuscular route every 10 weeks
Primary hypogonadism due to orchitis
- Inject 3 milliliters (750 mg) by intramuscular route every 10 weeks
- None
Contraindicated
- None
Severe
Moderate
- None
- Lactating mother
- Malignant tumor of male breast
- Pregnancy
- Prostatic carcinoma
Contraindicated
- Acute myocardial infarction
- Benign prostatic hyperplasia
- Cerebrovascular accident
- Chronic pulmonary disease
- Erythrocytosis
- Hypercholesterolemia
- Kidney disease with reduction in GFR
- Polycythemia vera
- Pulmonary thromboembolism
- Venous thrombosis
Severe
Moderate
- Chronic heart failure
- Diabetes mellitus
- Disease of liver
- Edema
- Gynecomastia
- Humoral hypercalcemia of malignancy
- Hypertension
- Obesity
- Sleep apnea
AVEED (TESTOSTERONE UNDECANOATE)
- Androgen deficiency
- Gonadotropin releasing factor deficiency
- Male hypogonadism
- Bilateral anorchia
- Bilateral orchiectomy
- Chemotherapy-induced hypogonadism
- Cryptorchidism
- Klinefelter's syndrome
- Primary hypogonadism due to bilateral torsion of testes
- Primary hypogonadism due to orchitis
- Gynecomastia
- Virilism
- Acne vulgaris
- Injection site sequelae
More Frequent
Severe
Less Severe
- Benign prostatic hyperplasia
- Edema
- Jaundice
- Prostatic carcinoma
- Diarrhea
- Disorder of ejaculation
- Insomnia
- Irritability
- Libido changes
- Oligospermia
- Testicular atrophy
- Weight gain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Anaphylaxis
- Angina
- Angioedema
- Asthma
- Cerebrovascular accident
- Cholestatic hepatitis
- Deep venous thrombosis
- Diabetes mellitus
- Drug-induced hepatitis
- Erythrocytosis
- Heart failure
- Hypercalcemia
- Hyperlipidemia
- Hypertension
- Kidney stone
- Malignant neoplasm of liver
- Peliosis hepatis
- Pharyngeal edema
- Prostatitis
- Pulmonary oil microembolism
- Pulmonary thromboembolism
- Sleep apnea
- Thrombocytopenic disorder
- Venous thrombosis
Less Severe
- Aggressive behavior
- Alopecia
- Anorexia
- Arthralgias
- Azoospermia
- Back pain
- Body fluid retention
- Depression
- Dyspnea
- Dysuria
- Erythema
- Fatigue
- Flushing
- Headache disorder
- Hostility
- Hyperhidrosis
- Malaise
- Mastalgia
- Mood changes
- Non-cardiac chest pain
- Orgasm disorder
- Paresthesia
- Pruritus of skin
- Tachycardia
- Tinnitus
- Upper abdominal pain
- Upper respiratory infection
- Vomiting
Contraindicated
None
Severe Precaution
Testosterone Undecanoate (Inj)
May cause premature epiphyseal closure. Safety and efficacy not established age<18 years.
- 1 Day – 18 Years
- May cause premature epiphyseal closure. Safety and efficacy not established age<18 years.
Management or Monitoring Precaution
None
Testosterone Undecanoate
- Severity Level:
X
- Additional Notes: Not indicated in females
Contraindicated
Testosterone
Poss sev adv effects, premature epiphyseal closure, virilization of females
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Poss sev adv effects, premature epiphyseal closure, virilization of females |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Testosterone
General-Avoid use in the elderly unless indicated for confirmed hypogonadism. Urogenital-Increased risk of acute kidney injury. May exacerbate prostate cancer. Cardiovascular-Reports of venous thromboembolism, deep vein thrombosis and pulmonary embolism. Possible increased risk of atrial fibrillation.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | Y | N | N | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- This medication can rarely cause a certain serious lung problem (pulmonary oil microembolism-POME), caused by tiny droplets of oil that have traveled to the lungs. Symptoms may include cough/urge to cough, difficulty breathing, sweating, tightening of the throat, chest pain, dizziness, or fainting. Most of the time, symptoms last only a few minutes and improve with medical help.<br /><br />However, symptoms have sometimes lasted up to several hours, or worsened and required treatment in a hospital. Serious (rarely fatal) allergic reactions may also occur. These side effects may happen during or right after each injection.<br /><br />To be sure that you do not have a serious reaction, you will need to stay in a health care setting for 30 minutes after each injection so your doctor can carefully monitor you and provide medical help if needed. This medication is available only through a restricted program called the Aveed REMS Program. Only doctors enrolled in the program may prescribe or give this medication.<br /><br />These requirements apply in the United States. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations.
Androgen deficiency | |
E29.1 | Testicular hypofunction |
Bilateral anorchia | |
Q55.0 | Absence and aplasia of testis |
Chemotherapy-induced hypogonadism | |
E29.1 | Testicular hypofunction |
Cryptorchidism | |
Q53 | Undescended and ectopic testicle |
Q53.0 | Ectopic testis |
Q53.00 | Ectopic testis, unspecified |
Q53.01 | Ectopic testis, unilateral |
Q53.02 | Ectopic testes, bilateral |
Q53.1 | Undescended testicle, unilateral |
Q53.10 | Unspecified undescended testicle, unilateral |
Q53.11 | Abdominal testis, unilateral |
Q53.111 | Unilateral intraabdominal testis |
Q53.112 | Unilateral inguinal testis |
Q53.12 | Ectopic perineal testis, unilateral |
Q53.13 | Unilateral high scrotal testis |
Q53.2 | Undescended testicle, bilateral |
Q53.20 | Undescended testicle, unspecified, bilateral |
Q53.21 | Abdominal testis, bilateral |
Q53.211 | Bilateral intraabdominal testes |
Q53.212 | Bilateral inguinal testes |
Q53.22 | Ectopic perineal testis, bilateral |
Q53.23 | Bilateral high scrotal testes |
Q53.9 | Undescended testicle, unspecified |
R39.83 | Unilateral non-palpable testicle |
R39.84 | Bilateral non-palpable testicles |
Gonadotropin releasing factor deficiency | |
E23.3 | Hypothalamic dysfunction, not elsewhere classified |
Klinefelter's syndrome | |
Q98.0 | Klinefelter syndrome karyotype 47, XXY |
Q98.1 | Klinefelter syndrome, male with more than two X chromosomes |
Q98.4 | Klinefelter syndrome, unspecified |
Male hypogonadism | |
E29.1 | Testicular hypofunction |
Primary hypogonadism due to bilateral torsion of testes | |
E29.1 | Testicular hypofunction |
Primary hypogonadism due to orchitis | |
E29.1 | Testicular hypofunction |
0-9 | A-Z |
---|---|
E23.3 | Hypothalamic dysfunction, not elsewhere classified |
E29.1 | Testicular hypofunction |
E29.1 | Testicular hypofunction |
E29.1 | Testicular hypofunction |
E29.1 | Testicular hypofunction |
E29.1 | Testicular hypofunction |
Q53 | Undescended and ectopic testicle |
Q53.0 | Ectopic testis |
Q53.00 | Ectopic testis, unspecified |
Q53.01 | Ectopic testis, unilateral |
Q53.02 | Ectopic testes, bilateral |
Q53.1 | Undescended testicle, unilateral |
Q53.10 | Unspecified undescended testicle, unilateral |
Q53.11 | Abdominal testis, unilateral |
Q53.111 | Unilateral intraabdominal testis |
Q53.112 | Unilateral inguinal testis |
Q53.12 | Ectopic perineal testis, unilateral |
Q53.13 | Unilateral high scrotal testis |
Q53.2 | Undescended testicle, bilateral |
Q53.20 | Undescended testicle, unspecified, bilateral |
Q53.21 | Abdominal testis, bilateral |
Q53.211 | Bilateral intraabdominal testes |
Q53.212 | Bilateral inguinal testes |
Q53.22 | Ectopic perineal testis, bilateral |
Q53.23 | Bilateral high scrotal testes |
Q53.9 | Undescended testicle, unspecified |
Q55.0 | Absence and aplasia of testis |
Q98.0 | Klinefelter syndrome karyotype 47, XXY |
Q98.1 | Klinefelter syndrome, male with more than two X chromosomes |
Q98.4 | Klinefelter syndrome, unspecified |
R39.83 | Unilateral non-palpable testicle |
R39.84 | Bilateral non-palpable testicles |