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BAVENCIO (AVELUMAB)
- Merkel cell carcinoma
- Renal cell carcinoma
- Transitional cell carcinoma of the urinary tract
20 mg/mL intravenous solution
- Infuse 800 mg over 60 minute(s) by intravenous route every 2 weeks
Merkel cell carcinoma
- Infuse 800 mg over 60 minute(s) by intravenous route every 2 weeks
Renal cell carcinoma
- Infuse 800 mg over 60 minute(s) by intravenous route every 2 weeks
Transitional cell carcinoma of the urinary tract
- Infuse 800 mg over 60 minute(s) by intravenous route every 2 weeks
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- None
- None
Contraindicated
- Abnormal hepatic function tests
- Adrenal cortical insufficiency
- Colitis
- Hyperthyroidism
- Hypoglycemic disorder
- Hypothyroidism
- Interstitial pneumonitis
- Nephritis
- Pregnancy
Severe
Moderate
- None
BAVENCIO (AVELUMAB)
- Merkel cell carcinoma
- Renal cell carcinoma
- Transitional cell carcinoma of the urinary tract
- Anemia
- Hypersensitivity drug reaction
- Lymphopenia
- Anorexia
- Diarrhea
- Fatigue
- Musculoskeletal pain
- Nausea
- Peripheral edema
- Skin rash
More Frequent
Severe
Less Severe
- Colitis
- Hypertension
- Hypertensive crisis
- Hyponatremia
- Hypotension
- Hypothyroidism
- Increased aspartate transaminase
- Interstitial pneumonitis
- Neutropenic disorder
- Thrombocytopenic disorder
- Acute abdominal pain
- Arthralgias
- Chills
- Constipation
- Dizziness
- Dyspnea
- Fever
- Headache disorder
- Pruritus of skin
- Urinary tract infection
- Vomiting
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Adrenal cortical insufficiency
- Autoimmune hepatitis
- Cerebrovascular accident
- Chronic heart failure
- Demyelination
- Diabetes mellitus
- Erythema multiforme
- Exfoliative dermatitis
- Guillain-barre syndrome
- Histiocytic necrotizing lymphadenitis
- Hyperthyroidism
- Hypophysitis
- Increased alanine transaminase
- Myocarditis
- Myositis
- Nephritis
- Pemphigoid
- Pituitary insufficiency
- Sepsis
- Thyroiditis
- Urosepsis
- Uveitis
- Vasculitis
Less Severe
- Arthritis
- Psoriasis
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Avelumab
No safety and efficacy established age < 12 years.
- 1 Day – 12 Years
- No safety and efficacy established age < 12 years.
Avelumab
- Severity Level:
D
- Additional Notes: Based on drug pharmacology, dev tox may occur.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Avelumab
Insuff data avail; mfr rec avoid breastfeeding during & 1 mo after treatment
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insuff data avail; mfr rec avoid breastfeeding during & 1 mo after treatment |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Merkel cell carcinoma | |
| C4A | Merkel cell carcinoma |
| C4A.0 | Merkel cell carcinoma of lip |
| C4A.1 | Merkel cell carcinoma of eyelid, including canthus |
| C4A.10 | Merkel cell carcinoma of unspecified eyelid, including canthus |
| C4A.11 | Merkel cell carcinoma of right eyelid, including canthus |
| C4A.111 | Merkel cell carcinoma of right upper eyelid, including canthus |
| C4A.112 | Merkel cell carcinoma of right lower eyelid, including canthus |
| C4A.12 | Merkel cell carcinoma of left eyelid, including canthus |
| C4A.121 | Merkel cell carcinoma of left upper eyelid, including canthus |
| C4A.122 | Merkel cell carcinoma of left lower eyelid, including canthus |
| C4A.2 | Merkel cell carcinoma of ear and external auricular canal |
| C4A.20 | Merkel cell carcinoma of unspecified ear and external auricular canal |
| C4A.21 | Merkel cell carcinoma of right ear and external auricular canal |
| C4A.22 | Merkel cell carcinoma of left ear and external auricular canal |
| C4A.3 | Merkel cell carcinoma of other and unspecified parts of face |
| C4A.30 | Merkel cell carcinoma of unspecified part of face |
| C4A.31 | Merkel cell carcinoma of nose |
| C4A.39 | Merkel cell carcinoma of other parts of face |
| C4A.4 | Merkel cell carcinoma of scalp and neck |
| C4A.5 | Merkel cell carcinoma of trunk |
| C4A.51 | Merkel cell carcinoma of anal skin |
| C4A.52 | Merkel cell carcinoma of skin of breast |
| C4A.59 | Merkel cell carcinoma of other part of trunk |
| C4A.6 | Merkel cell carcinoma of upper limb, including shoulder |
| C4A.60 | Merkel cell carcinoma of unspecified upper limb, including shoulder |
| C4A.61 | Merkel cell carcinoma of right upper limb, including shoulder |
| C4A.62 | Merkel cell carcinoma of left upper limb, including shoulder |
| C4A.7 | Merkel cell carcinoma of lower limb, including hip |
| C4A.70 | Merkel cell carcinoma of unspecified lower limb, including hip |
| C4A.71 | Merkel cell carcinoma of right lower limb, including hip |
| C4A.72 | Merkel cell carcinoma of left lower limb, including hip |
| C4A.8 | Merkel cell carcinoma of overlapping sites |
| C4A.9 | Merkel cell carcinoma, unspecified |
| C7B.1 | Secondary merkel cell carcinoma |
| Renal cell carcinoma | |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| Transitional cell carcinoma of the urinary tract | |
| C65 | Malignant neoplasm of renal pelvis |
| C65.1 | Malignant neoplasm of right renal pelvis |
| C65.2 | Malignant neoplasm of left renal pelvis |
| C65.9 | Malignant neoplasm of unspecified renal pelvis |
| C66 | Malignant neoplasm of ureter |
| C66.1 | Malignant neoplasm of right ureter |
| C66.2 | Malignant neoplasm of left ureter |
| C66.9 | Malignant neoplasm of unspecified ureter |
| C67 | Malignant neoplasm of bladder |
| C67.0 | Malignant neoplasm of trigone of bladder |
| C67.1 | Malignant neoplasm of dome of bladder |
| C67.2 | Malignant neoplasm of lateral wall of bladder |
| C67.3 | Malignant neoplasm of anterior wall of bladder |
| C67.4 | Malignant neoplasm of posterior wall of bladder |
| C67.5 | Malignant neoplasm of bladder neck |
| C67.6 | Malignant neoplasm of ureteric orifice |
| C67.8 | Malignant neoplasm of overlapping sites of bladder |
| C67.9 | Malignant neoplasm of bladder, unspecified |
| 0-9 | A-Z |
|---|---|
| C4A | Merkel cell carcinoma |
| C4A.0 | Merkel cell carcinoma of lip |
| C4A.1 | Merkel cell carcinoma of eyelid, including canthus |
| C4A.10 | Merkel cell carcinoma of unspecified eyelid, including canthus |
| C4A.11 | Merkel cell carcinoma of right eyelid, including canthus |
| C4A.111 | Merkel cell carcinoma of right upper eyelid, including canthus |
| C4A.112 | Merkel cell carcinoma of right lower eyelid, including canthus |
| C4A.12 | Merkel cell carcinoma of left eyelid, including canthus |
| C4A.121 | Merkel cell carcinoma of left upper eyelid, including canthus |
| C4A.122 | Merkel cell carcinoma of left lower eyelid, including canthus |
| C4A.2 | Merkel cell carcinoma of ear and external auricular canal |
| C4A.20 | Merkel cell carcinoma of unspecified ear and external auricular canal |
| C4A.21 | Merkel cell carcinoma of right ear and external auricular canal |
| C4A.22 | Merkel cell carcinoma of left ear and external auricular canal |
| C4A.3 | Merkel cell carcinoma of other and unspecified parts of face |
| C4A.30 | Merkel cell carcinoma of unspecified part of face |
| C4A.31 | Merkel cell carcinoma of nose |
| C4A.39 | Merkel cell carcinoma of other parts of face |
| C4A.4 | Merkel cell carcinoma of scalp and neck |
| C4A.5 | Merkel cell carcinoma of trunk |
| C4A.51 | Merkel cell carcinoma of anal skin |
| C4A.52 | Merkel cell carcinoma of skin of breast |
| C4A.59 | Merkel cell carcinoma of other part of trunk |
| C4A.6 | Merkel cell carcinoma of upper limb, including shoulder |
| C4A.60 | Merkel cell carcinoma of unspecified upper limb, including shoulder |
| C4A.61 | Merkel cell carcinoma of right upper limb, including shoulder |
| C4A.62 | Merkel cell carcinoma of left upper limb, including shoulder |
| C4A.7 | Merkel cell carcinoma of lower limb, including hip |
| C4A.70 | Merkel cell carcinoma of unspecified lower limb, including hip |
| C4A.71 | Merkel cell carcinoma of right lower limb, including hip |
| C4A.72 | Merkel cell carcinoma of left lower limb, including hip |
| C4A.8 | Merkel cell carcinoma of overlapping sites |
| C4A.9 | Merkel cell carcinoma, unspecified |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| C65 | Malignant neoplasm of renal pelvis |
| C65.1 | Malignant neoplasm of right renal pelvis |
| C65.2 | Malignant neoplasm of left renal pelvis |
| C65.9 | Malignant neoplasm of unspecified renal pelvis |
| C66 | Malignant neoplasm of ureter |
| C66.1 | Malignant neoplasm of right ureter |
| C66.2 | Malignant neoplasm of left ureter |
| C66.9 | Malignant neoplasm of unspecified ureter |
| C67 | Malignant neoplasm of bladder |
| C67.0 | Malignant neoplasm of trigone of bladder |
| C67.1 | Malignant neoplasm of dome of bladder |
| C67.2 | Malignant neoplasm of lateral wall of bladder |
| C67.3 | Malignant neoplasm of anterior wall of bladder |
| C67.4 | Malignant neoplasm of posterior wall of bladder |
| C67.5 | Malignant neoplasm of bladder neck |
| C67.6 | Malignant neoplasm of ureteric orifice |
| C67.8 | Malignant neoplasm of overlapping sites of bladder |
| C67.9 | Malignant neoplasm of bladder, unspecified |
| C7B.1 | Secondary merkel cell carcinoma |
Formulary Reference Tool