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ZIAC (BISOPROLOL FUMARATE/HYDROCHLOROTHIAZIDE)
- Hypertension
10 mg-6.25 mg tablet
- 1 tablet by oral route once daily
2.5 mg-6.25 mg tablet
- 1 tablet by oral route once daily
5 mg-6.25 mg tablet
- 1 tablet by oral route once daily
bisoprolol 10 mg-hydrochlorothiazide 6.25 mg tablet
- 1 tablet by oral route once daily
bisoprolol 2.5 mg-hydrochlorothiazide 6.25 mg tablet
- 1 tablet by oral route once daily
bisoprolol 5 mg-hydrochlorothiazide 6.25 mg tablet
- 1 tablet by oral route once daily
Hypertension
- 1 tablet by oral route once daily
- dofetilide
- Tikosyn
Contraindicated
- Oral Saline Laxative
- Osmoprep
- Phosphate Laxative
- Preparation Cleansing
- methenamine mand-sod biphos
- Lithobid
- lithium citrate
- lithium carbonate
- Kapvay
- Gilenya
- Fleet Pediatric
- Fleet Enema Extra
- Fleet Enema
- fingolimod
- fenoldopam
- Enema Disposable
- Enema
- Duraclon (pf)
- Disposable Enema
- Curad Enema
- Corlopam
- Clorpres
- clonidine-chlorthalidone
- clonidine (PF)
- clonidine
- Catapres-tts-3
- Catapres-tts-2
- Catapres-tts-1
- Catapres
- Ready-to-use Enema
- Reclast
- sod phos mono-sod phos dibasic
- sodium phosphates
- Uroqid-acid No.2
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- acarbose
- Adalat Cc
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Afeditab Cr
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Amaryl
- Anaprox
- Anaprox Ds
- Ansaid
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- nateglinide
- Neoprofen (ibuprofen Lysn)(pf)
- Nifedical Xl
- nifedipine
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- pioglitazone-glimepiride
- piroxicam
- Precose
- Prevalite
- Procardia
- Procardia Xl
- Proglycem
- Provil
- pseudoephedrine-ibuprofen
- Motrin Pm
- Motrin Ib
- Mobic
- miglitol
- Midol (naproxen)
- meloxicam
- Mediproxen
- Medi-profen
- Matzim La
- Levemir Flexpen
- Levemir
- Lantus Solostar
- Lantus
- Lanoxin Pediatric
- Lanoxin
- insulin regular human
- insulin regular hum U-500 conc
- insulin NPH and regular human
- insulin lispro protam-lispro
- insulin lispro
- insulin glulisine
- insulin glargine
- insulin detemir
- insulin aspart
- insulin asp prt-insulin aspart
- Infants Profenib
- Infants Ibu-drops
- Infant's Motrin
- Infant's Medi-profen
- Infant's Ibuprofen
- indomethacin sodium
- indomethacin
- Indocin
- ibuprofen-phenylephrine HCl
- ibuprofen-oxycodone
- ibuprofen-famotidine
- ibuprofen-diphenhydramine HCl
- ibuprofen-diphenhydramine
- Ibuprofen Pm
- ibuprofen lysine (PF)
- Ibuprofen Jr Strength
- Ibuprofen Ib
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Cold
- ibuprofen
- Ibudone
- Ibu-drops
- I-prin
- hydrocodone-ibuprofen
- Humulin R U-500 "Concentrated"
- Humulin R
- Humulin N Kwikpen
- Humulin N
- Humulin 70/30
- Humalog Mix 75-25 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 50-50
- Humalog Kwikpen
- Humalog
- Glyset
- Glynase
- glyburide-metformin
- glyburide micronized
- glyburide
- Glucovance
- Glucotrol Xl
- Glucotrol
- glipizide-metformin
- glipizide
- glimepiride
- flurbiprofen
- Flanax
- Feldene
- Ec-naprosyn
- Duexis
- Duetact
- diltiazem HCl
- Dilt-xr
- Dilacor Xr
- digoxin
- Digox
- diazoxide
- Diabeta
- colestipol
- Colestid Flavored
- Colestid
- Cold-sinus Relief
- Cold & Sinus Pain Relief
- cholestyramine-aspartame
- Cholestyramine Light
- cholestyramine (with sugar)
- chlorphen-pseudoeph-ibuprofen
- chlorphen-phenyleph-ibuprofen
- Children's Profen Ib
- Children's Motrin
- Children's Medi-profen
- Children's Ibuprofen
- Children's Ibu-drops
- Children's Advil
- Child Ibuprofen
- Cartia Xt
- Cardizem La
- Cardizem Cd
- Cardizem
- Caldolor
- Calan Sr
- Calan
- Apidra Solostar
- Apidra
- Questran
- Questran Light
- Reprexain
- Sinus & Cold-d
- Starlix
- sulindac
- Tarka
- Taztia Xt
- Tiazac
- tolazamide
- tolbutamide
- trandolapril-verapamil
- verapamil
- Verelan
- Verelan Pm
- Vicoprofen
- Vimovo
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Acute asthma attack
- Acute decompensated heart failure
- Anuria
- Cardiogenic shock
- Complete atrioventricular block
- Pregnancy
- Second degree atrioventricular heart block
Contraindicated
- Acute pancreatitis
- Azotemia
- Dehydration
- Gout
- Hepatic failure
- Hyperuricemia
- Hypochloremic alkalosis
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Hypovolemia
- Neonatal hyperbilirubinemia
- Pheochromocytoma
- Renal disease with moderate to severe impairment
- Secondary angle-closure glaucoma
- Severe chronic obstructive pulmonary disease
- Sinus bradycardia
Severe
Moderate
- Asthma
- Basal cell carcinoma of skin
- Depression
- Diabetes mellitus
- Disease of liver
- Hypercalcemia
- Hypercholesterolemia
- Hyperparathyroidism
- Myasthenia gravis
- Peripheral vascular disease
- Psoriasis
- Raynaud's phenomenon
- Squamous cell carcinoma of skin
- Sympathectomy
- Systemic lupus erythematosus
ZIAC (BISOPROLOL FUMARATE/HYDROCHLOROTHIAZIDE)
- Hypertension
- Hypochloremic alkalosis
- Hypokalemia
- Hyponatremia
- Hypotension
- Fatigue
- General weakness
More Frequent
Severe
Less Severe
- Arthralgias
- Bronchospastic pulmonary disease
- Chest pain
- Hyperglycemia
- Hypomagnesemia
- Kidney disease with reduction in GFR
- Abdominal pain with cramps
- Abnormal sexual function
- Anorexia
- Diarrhea
- Dizziness
- Drowsy
- Dyspnea
- Fatigue
- Insomnia
- Nasal congestion
- Nausea
- Nervousness
- Orthostatic hypotension
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute confusion
- Acute pancreatitis
- Agranulocytosis
- Anaphylaxis
- Aplastic anemia
- Bradycardia
- Cardiac arrhythmia
- Chronic heart failure
- Erythema multiforme
- Exfoliative dermatitis
- Gastritis
- Gout
- Hallucinations
- Hemolytic anemia
- Hepatitis
- Hypercalcemia
- Hyperparathyroidism
- Hypersensitivity angiitis
- Hyperuricemia
- Interstitial nephritis
- Interstitial pneumonitis
- Ischemic colitis
- Jaundice
- Laryngismus
- Leukopenia
- Myopia
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Orthostatic hypotension
- Peptic ulcer
- Peripheral vasoconstriction
- Peyronie's disease
- Psoriasiform eruption
- Purpura
- Renal colic
- Secondary angle-closure glaucoma
- Squamous cell carcinoma of skin
- Stevens-johnson syndrome
- Systemic lupus erythematosus
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Vasculitis
Less Severe
- Abdominal pain with cramps
- Abnormal hepatic function tests
- Basal cell carcinoma of skin
- Blurred vision
- Constipation
- Cramps
- Cystitis
- Dizziness
- Dream disorder
- Dry eye
- Dysgeusia
- Dyspepsia
- Erectile dysfunction
- Fever
- Gastrointestinal irritation
- General weakness
- Headache disorder
- Hearing loss
- Hypercholesterolemia
- Hypertriglyceridemia
- Hypesthesia
- Libido changes
- Mood changes
- Muscle spasm
- Nervousness
- Ocular irritation
- Paresthesia
- Polyuria
- Pruritus of skin
- Sialoadenitis
- Skin rash
- Symptoms of anxiety
- Tinnitus
- Upper respiratory infection
- Urticaria
- Vertigo
- Xanthopsia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Bisoprolol
Safety and efficacy not established in pediatrics.
- 1 Day – 18 Years
- Safety and efficacy not established in pediatrics.
Bisoprolol
- Severity Level:
1
- Additional Notes: Fda c, reports of intrauterine growth retard;monitor fetus/infant for b-blockade
Hydrochlorothiazide
- Severity Level:
B
- Additional Notes: Not recommended in pre-eclampsia and other pregnancy-induced hypertension.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Bisoprolol
Excret in animal studies;Monitor for signs of b-block:Bradycardia,hypotension
Limited amounts excreted with no known adverse effects in infant.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Excret in animal studies;Monitor for signs of b-block:Bradycardia,hypotension |
Hydrochlorothiazide
Excret in animal studies;Monitor for signs of b-block:Bradycardia,hypotension
Limited amounts excreted with no known adverse effects in infant.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited amounts excreted with no known adverse effects in infant. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
Formulary Reference Tool