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DONEPEZIL HCL (DONEPEZIL HCL)
- Mild to moderate alzheimer's type dementia
- Moderate to severe alzheimer's type dementia
10 mg tablet
- 1 tablet (10 mg) by oral route once daily in the evening
23 mg tablet
- 1 tablet (23 mg) by oral route once daily in the evening
5 mg tablet
- 1 tablet (5 mg) by oral route once daily in the evening
donepezil 10 mg tablet
- 1 tablet (10 mg) by oral route once daily in the evening
donepezil 23 mg tablet
- 1 tablet (23 mg) by oral route once daily in the evening
donepezil 5 mg tablet
- 1 tablet (5 mg) by oral route once daily in the evening
10 mg tablet
- 1 tablet (10 mg) by oral route once daily in the evening
23 mg tablet
- 1 tablet (23 mg) by oral route once daily in the evening
5 mg tablet
- 1 tablet (5 mg) by oral route once daily in the evening
Mild to moderate alzheimer's type dementia
- 1 tablet (5 mg) by oral route once daily in the evening
- 2 tablets (10 mg) by oral route once daily in the evening
- 1 tablet (10 mg) by oral route once daily in the evening
Moderate to severe alzheimer's type dementia
- 2 tablets (10 mg) by oral route once daily in the evening
- 1 tablet (10 mg) by oral route once daily in the evening
- 1 tablet (23 mg) by oral route once daily in the evening
- amiodarone
- amiodarone in dextrose,iso-osm
- artemether-lumefantrine
- Coartem
- Cordarone
- disopyramide
- dronedarone
- droperidol
- Multaq
- Nexterone
- Norpace
- Norpace Cr
- Orap
- Pacerone
- pimozide
Contraindicated
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- Caprelsa
- dofetilide
- Fareston
- Geodon
- Invega
- Invega Sustenna
- Invirase
- Kaletra
- lopinavir-ritonavir
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- nilotinib
- paliperidone
- paliperidone palmitate
- propafenone
- Qualaquin
- quetiapine
- quinine sulfate
- Rythmol
- saquinavir mesylate
- Seroquel
- Seroquel Xr
- Tasigna
- tetrabenazine
- thioridazine
- Tikosyn
- toremifene
- vandetanib
- Xenazine
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- alfuzosin
- Anectine
- Anzemet
- Apokyn
- apomorphine
- clozapine
- Clozaril
- Complera
- dasatinib
- dolasetron
- Edurant
- emtricitab-rilpivirine-tenofov
- Fazaclo
- lapatinib
- norfloxacin
- Noroxin
- Noxafil
- pasireotide
- pazopanib
- posaconazole
- Quelicin
- rilpivirine
- Signifor
- Sprycel
- succinylcholine chloride
- Tykerb
- Uroxatral
- Versacloz
- Vfend
- Vfend Iv
- voriconazole
- Votrient
- Torsades de pointes
Contraindicated
- Atrioventricular block
- Gastrointestinal hemorrhage
- Gastrointestinal ulcer
- Neuroleptic malignant syndrome
- Rhabdomyolysis
- Sick sinus syndrome
- Sinus bradycardia
Severe
Moderate
- Asthma
- Bladder outflow obstruction
- Chronic obstructive pulmonary disease with bronchospasms
- Seizure disorder
DONEPEZIL HCL (DONEPEZIL HCL)
- Mild to moderate alzheimer's type dementia
- Moderate to severe alzheimer's type dementia
- Diarrhea
- Cramps
- Insomnia
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Anorexia
- Arthritis
- Dizziness
- Fatigue
- Increased urinary frequency
- Syncope
- Depression
- Drowsy
- Ecchymosis
- Headache disorder
- Nightmares
- Pain
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abdominal pain with cramps
- Aggressive behavior
- Anemia
- Aphasia
- Ataxia
- Atrial fibrillation
- Blurred vision
- Bradycardia
- Cataracts
- Chest pain
- Dehydration
- Delusional disorder
- DRESS syndrome
- Dyspnea
- Fecal incontinence
- Flatulence
- Gastrointestinal hemorrhage
- Heart block
- Heart failure
- Hyperhidrosis
- Hypertension
- Hypotension
- Nervousness
- Neuroleptic malignant syndrome
- Paresthesia
- Peripheral edema
- Prolonged QT interval
- Rhabdomyolysis
- Seizure disorder
- Stevens-johnson syndrome
- Torsades de pointes
- Toxic epidermal necrolysis
- Urticaria
Less Severe
- Abnormal hepatic function tests
- Altered mental status
- Bronchitis
- Drug-induced hot flash
- Genitourinary tract infections
- Irritability
- Libido changes
- Mood changes
- Nocturia
- Ocular irritation
- Pruritus of skin
- Tremor
- Urinary incontinence
- Vasodilation of blood vessels
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Donepezil
No approved indications for treating children. No safety and efficacy established.
- 1 Day – 18 Years
- No approved indications for treating children. No safety and efficacy established.
Donepezil
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Donepezil
Insufficient data available.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Donepezil
General-Recent rare reports of rhabdomyolysis and NMS. Cardiovascular-Cholinesterase inhibitors can have vagotonic effects on the SA & AV nodes resulting in bradycardia or AV block. Urogenital-May cause bladder outflow obstruction in those patients who are predisposed. Gastrointestinal-Use with caution in patients with history of or active PUD or GI bleeding. Dose dependent N/V, diarrhea.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | N | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- None
| Mild to moderate alzheimer's type dementia | |
| G30 | Alzheimer's disease |
| G30.0 | Alzheimer's disease with early onset |
| G30.1 | Alzheimer's disease with late onset |
| G30.8 | Other alzheimer's disease |
| G30.9 | Alzheimer's disease, unspecified |
| Moderate to severe alzheimer's type dementia | |
| G30 | Alzheimer's disease |
| G30.0 | Alzheimer's disease with early onset |
| G30.1 | Alzheimer's disease with late onset |
| G30.8 | Other alzheimer's disease |
| G30.9 | Alzheimer's disease, unspecified |
| 0-9 | A-Z |
|---|---|
| G30 | Alzheimer's disease |
| G30 | Alzheimer's disease |
| G30.0 | Alzheimer's disease with early onset |
| G30.0 | Alzheimer's disease with early onset |
| G30.1 | Alzheimer's disease with late onset |
| G30.1 | Alzheimer's disease with late onset |
| G30.8 | Other alzheimer's disease |
| G30.8 | Other alzheimer's disease |
| G30.9 | Alzheimer's disease, unspecified |
| G30.9 | Alzheimer's disease, unspecified |
Formulary Reference Tool