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TUSSIN DM DAY-NIGHT (doxylamine succinate/dextromethorphan HBr/guaifenesin)
- Allergic rhinitis
- Cold symptoms
- Cough
- Nasal congestion
- Rhinorrhea
12.5 mg-30 mg/10 mL (night) oral liquid
- Dosage information is not available
- Azilect
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- rasagiline
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Chronic idiopathic constipation
- Stenosing peptic ulcer
- Systemic mastocytosis
- Urinary retention
Severe
Moderate
- Hypertension
- Hyperthyroidism
- No disease contraindications
- Ocular hypertension
TUSSIN DM DAY-NIGHT (doxylamine succinate/dextromethorphan HBr/guaifenesin)
- Allergic rhinitis
- Cold symptoms
- Cough
- Nasal congestion
- Rhinorrhea
- None
- Dizziness
- Drowsy
- Thick bronchial secretions
More Frequent
Severe
Less Severe
- None
- Sedation
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Blood dyscrasias
- Extrasystoles
- Hallucinations
- Hemolytic anemia
- Hypotension
- Seizure disorder
- Vomiting
Less Severe
- Abdominal distension
- Abdominal pain with cramps
- Acute abdominal pain
- Acute confusion
- Anorexia
- Ataxia
- Blurred vision
- Chest discomfort
- Chills
- Constipation
- Diarrhea
- Diplopia
- Dizziness
- Drowsy
- Dry nose
- Dry throat
- Dyspnea
- Dysuria
- Euphoria
- Excitement
- Fatigue
- Gastrointestinal irritation
- Headache disorder
- Hyperhidrosis
- Insomnia
- Irritability
- Maculopapular rash
- Malaise
- Migraine
- Nausea
- Nervousness
- Nightmares
- Palpitations
- Paresthesia
- Pruritus of skin
- Skin photosensitivity
- Skin rash
- Symptoms of anxiety
- Tachycardia
- Tinnitus
- Tremor
- Urinary retention
- Urticaria
- Vertigo
- Visual changes
- Vomiting
- Wheezing
- Xerostomia
Contraindicated
Dextromethorphan (OTC)
Do not use in pediatrics <6 years of age unless clinician consultation.
CNS excitation and convulsion risk in newborns. Avoid use with age <2 years.
- 1 Day – 6 Years
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
- 1 Day – 2 Years
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
Doxylamine
Do not use in pediatrics <6 years of age unless clinician consultation.
CNS excitation and convulsion risk in newborns. Avoid use with age <2 years.
- 1 Day – 6 Years
- 1 CNS excitation and convulsion risk in newborns. Avoid use with age <2 years.
- 1 Day – 2 Years
- 1 CNS excitation and convulsion risk in newborns. Avoid use with age <2 years.
Severe Precaution
Doxylamine
CNS and respiratory depression, or excitation. Avoid using with underlying asthma. Consult clinician for use in patient age < 6 years.
- 2 Years – 6 Years
- CNS and respiratory depression, or excitation. Avoid using with underlying asthma. Consult clinician for use in patient age < 6 years.
Management or Monitoring Precaution
Guaifenesin (solid dose form)
Consult clinician for use in pediatrics age < 12 years.
- 1 Day – 12 Years
- Consult clinician for use in pediatrics age < 12 years.
Dextromethorphan
- Severity Level:
C
- Additional Notes:
Doxylamine
- Severity Level:
2
- Additional Notes: Compatible per briggs;overwhelming human and animal data suggests compatibility
Guaifenesin
- Severity Level:
C
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Dextromethorphan
Insufficient data available; molecular wt low enough for possible excretion
Low molec wt. possible excretion; not recom; may cause paradoxical excitation
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available; molecular wt low enough for possible excretion |
Doxylamine
Insufficient data available; molecular wt low enough for possible excretion
Low molec wt. possible excretion; not recom; may cause paradoxical excitation
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Low molec wt. possible excretion; not recom; may cause paradoxical excitation |
Guaifenesin
Insufficient data available; molecular wt low enough for possible excretion
Low molec wt. possible excretion; not recom; may cause paradoxical excitation
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Doxylamine
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating antihistamine preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- None
| Allergic rhinitis | |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| Cold symptoms | |
| J00 | Acute nasopharyngitis [common cold] |
| Cough | |
| R05 | Cough |
| Nasal congestion | |
| R09.81 | Nasal congestion |
| Rhinorrhea | |
| R09.82 | Postnasal drip |
| 0-9 | A-Z |
|---|---|
| J00 | Acute nasopharyngitis [common cold] |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| R05 | Cough |
| R09.81 | Nasal congestion |
| R09.82 | Postnasal drip |
Formulary Reference Tool