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STIMATE (DESMOPRESSIN ACETATE)
- Hemophilia A
- Von willebrand's disease
150 mcg/spray (0.1 mL) nasal spray
- Spray 2 sprays (300 mcg) by intranasal route once daily
Hemophilia A
- Spray 1 spray (150 mcg) by intranasal route once daily
- Spray 2 sprays (300 mcg) by intranasal route once daily
Von willebrand's disease
- Spray 1 spray (150 mcg) by intranasal route once daily
- Spray 2 sprays (300 mcg) by intranasal route once daily
- None
Contraindicated
- None
Severe
Moderate
- None
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
Contraindicated
- Hyponatremia
- Kidney disease with likely reduction in GFR
- Psychogenic polydipsia
- Severe allergic rhinitis
Severe
Moderate
- Allergic rhinitis
- Chronic heart failure
- Coronary artery disease
- Cystic fibrosis
- Hypertension
STIMATE (DESMOPRESSIN ACETATE)
- Hemophilia A
- Von willebrand's disease
- None
- None
More Frequent
Severe
Less Severe
- Hypertension
- Abdominal pain with cramps
- Back pain
- Body fluid retention
- Bronchitis
- Chills
- Dizziness
- Epistaxis
- Headache disorder
- Nasal passage irritation
- Nausea
- Sneezing
- Vulvodynia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute respiratory insufficiency
- Anaphylaxis
- Atrial fibrillation
- Chest pain
- Hyponatremia
- Seizure disorder
- Water intoxication
Less Severe
- Agitation
- Balanitis
- Cough
- Drowsy
- Dyspepsia
- Dysuria
- Edema
- Flushing
- Insomnia
- Nasal congestion
- Ocular itching
- Palpitations
- Rhinitis
- Sore throat
- Tachycardia
- Upper respiratory infection
- Vomiting
Contraindicated
None
Severe Precaution
Desmopressin (Nasal)
Contraindicated for treatment of primary nocturnal enuresis. Risk of water intoxication, hyponatremia and seizure. Monitor fluid intake.
- 1 Day – 18 Years
- Contraindicated for treatment of primary nocturnal enuresis. Risk of water intoxication, hyponatremia and seizure. Monitor fluid intake.
Management or Monitoring Precaution
None
Desmopressin Acetate
- Severity Level:
2
- Additional Notes: Limited human data do not suggest a clear association for development toxicity.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
Desmopressin
Limited data suggest negligible amount in breastmilk and poor oral absorption
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Excreted | Not known; no or inclusive data | Limited data suggest negligible amount in breastmilk and poor oral absorption |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Hemophilia A | |
| D66 | Hereditary factor VIII deficiency |
| Z14.02 | Symptomatic hemophilia A carrier |
| Von willebrand's disease | |
| D68.0 | Von willebrand's disease |
| 0-9 | A-Z |
|---|---|
| D66 | Hereditary factor VIII deficiency |
| D68.0 | Von willebrand's disease |
| Z14.02 | Symptomatic hemophilia A carrier |
Formulary Reference Tool