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PROVIGIL (MODAFINIL)
- Narcolepsy syndrome
- Sleepiness due to obstructive sleep apnea
- Sleepiness due to shift work sleep disorder
100 mg tablet
- 2 tablets (200 mg) by oral route once daily in the morning
200 mg tablet
- 1 tablet (200 mg) by oral route once daily in the morning
100 mg tablet
- 2 tablets (200 mg) by oral route once daily in the morning
200 mg tablet
- 1 tablet (200 mg) by oral route once daily in the morning
Narcolepsy syndrome
- 2 tablets (200 mg) by oral route once daily in the morning
- 1 tablet (200 mg) by oral route once daily in the morning
Sleepiness due to obstructive sleep apnea
- 2 tablets (200 mg) by oral route once daily in the morning
- 1 tablet (200 mg) by oral route once daily in the morning
Sleepiness due to shift work sleep disorder
- 2 tablets (200 mg) by oral route once daily in the morning
- 1 tablet (200 mg) by oral route once daily in the morning
- None
Contraindicated
- Altavera (28)
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Amethia
- Amethia Lo
- Amethyst
- Apri
- Aranelle (28)
- Aubra
- Aviane
- axitinib
- Azurette (28)
- Balziva (28)
- bedaquiline
- Beyaz
- Bosulif
- bosutinib
- Brevicon (28)
- Briellyn
- Camila
- Camrese
- Camrese Lo
- Caziant (28)
- Chateal
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- Depo-provera
- Depo-subq Provera 104
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- drospirenone-e.estradiol-lm.FA
- drospirenone-ethinyl estradiol
- Elinest
- Emoquette
- Enpresse
- Enskyce
- enzalutamide
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estrostep Fe-28
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- Falmina (28)
- Femcon Fe
- Generess Fe
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- guanfacine
- Heather
- Inlyta
- Introvale
- Intuniv Er
- Jencycla
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kariva (28)
- Kelnor 1/35 (28)
- Kurvelo
- L norgest&E estradiol-E estrad
- Larin 1/20 (21)
- Larin Fe
- Leena 28
- Lessina
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- Lo Loestrin Fe
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- Loryna (28)
- Loseasonique
- Low-ogestrel (28)
- Lutera (28)
- Lyza
- Marlissa
- medroxyprogesterone
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- Minastrin 24 Fe
- Mircette (28)
- Mirena
- Modicon (28)
- Mono-linyah
- Mononessa (28)
- My Way
- Myzilra
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Nexplanon
- Next Choice One Dose
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Nuvaring
- Ocella
- Ogestrel (28)
- Olysio
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- Philith
- Pimtrea (28)
- Pirmella
- Plan B One-step
- Portia
- Previfem
- Quartette
- Quasense
- Reclipsen (28)
- Safyral
- Seasonique
- simeprevir
- Sirturo
- Skyla
- Sprintec (28)
- Sronyx
- Syeda
- Tenex
- Tilia Fe
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- Trinessa (28)
- Trivora (28)
- Velivet Triphasic Regimen (28)
- Vestura (28)
- Viorele (28)
- Vyfemla (28)
- Wera (28)
- Wymzya Fe
- Xtandi
- Yasmin (28)
- Yaz 28
- Zarah
- Zenchent (28)
- Zenchent Fe
- Zeosa
- Zovia 1/35E (28)
- Zovia 1/50E (28)
Severe
Moderate
- clopidogrel
- Plavix
- Pregnancy
Contraindicated
- Acute myocardial infarction
- Depression
- Left ventricular hypertrophy
- Manic disorder
- Mitral valve prolapse
- Myocardial ischemia
- Psychotic disorder
- Severe hepatic disease
- Suicidal ideation
- Unstable angina pectoris
Severe
Moderate
- Aggressive behavior
- Hypertension
- Severe renal impairment
PROVIGIL (MODAFINIL)
- Narcolepsy syndrome
- Sleepiness due to obstructive sleep apnea
- Sleepiness due to shift work sleep disorder
- None
- Back pain
- Diarrhea
- Dizziness
- Dyspepsia
- Headache disorder
- Insomnia
- Nausea
- Nervousness
- Rhinitis
- Symptoms of anxiety
More Frequent
Severe
Less Severe
- Acute confusion
- Amblyopia
- Cardiac arrhythmia
- Chest pain
- Chills
- Depression
- Dyskinesia
- Fever
- Hyperglycemia
- Hypertension
- Hypotension
- Memory impairment
- Mood changes
- Pharyngitis
- Tachycardia
- Urinary retention
- Visual changes
- Anorexia
- Constipation
- Flu-like symptoms
- Hypertonia
- Palpitations
- Paresthesia
- Polydipsia
- Tremor
- Vasodilation of blood vessels
- Vomiting
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal desquamation
- Abnormal ECG
- Abnormal hepatic function tests
- Agranulocytosis
- Anaphylaxis
- Angioedema
- Asthma
- Asystole
- Blistering skin
- DRESS syndrome
- Dyspnea
- Edema
- Eosinophilia
- Hematuria
- Hepatitis
- Hyperkinesis
- Leukopenia
- Manic disorder
- Myocarditis
- Neutropenic disorder
- Psychiatric disorder
- Skin rash
- Stevens-johnson syndrome
- Stomatitis
- Suicidal ideation
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Urticaria
Less Severe
- Aggressive behavior
- Agitation
- Dysgeusia
- Flatulence
- General weakness
- Hyperhidrosis
- Pruritus of skin
Contraindicated
None
Severe Precaution
Modafinil
May cause severe rash in children under 16 years. Lack of efficacy data for improving sleep latency. Not approved for pediatrics.
Severe skin rash, leukopenia, dysmenorrhea, and psychiatric disturbances reported.
- 1 Day – 16 Years
- May cause severe rash in children under 16 years. Lack of efficacy data for improving sleep latency. Not approved for pediatrics.
- Severe skin rash, leukopenia, dysmenorrhea, and psychiatric disturbances reported.
- 16 Years – 18 Years
- May cause severe rash in children under 16 years. Lack of efficacy data for improving sleep latency. Not approved for pediatrics.
- Severe skin rash, leukopenia, dysmenorrhea, and psychiatric disturbances reported.
Management or Monitoring Precaution
None
Modafinil
- Severity Level:
1
- Additional Notes: Registry data suggest developmental toxicity
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Modafinil
Insufficient data available; molecular wt low enough for possible excretion
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available; molecular wt low enough for possible excretion |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Modafinil
General-Decreased clearance in the elderly. Use lower doses. Cardiovascular-Caution with underlying cardiovascular disease. Neuro/Psych-Avoid use in patients with insomnia.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | Y | Y | N | N |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- None
| Narcolepsy syndrome | |
| G47.4 | Narcolepsy and cataplexy |
| G47.41 | Narcolepsy |
| G47.411 | Narcolepsy with cataplexy |
| G47.419 | Narcolepsy without cataplexy |
| G47.42 | Narcolepsy in conditions classified elsewhere |
| G47.421 | Narcolepsy in conditions classified elsewhere with cataplexy |
| G47.429 | Narcolepsy in conditions classified elsewhere without cataplexy |
| Sleepiness due to shift work sleep disorder | |
| G47.26 | Circadian rhythm sleep disorder, shift work type |
| 0-9 | A-Z |
|---|---|
| G47.26 | Circadian rhythm sleep disorder, shift work type |
| G47.4 | Narcolepsy and cataplexy |
| G47.41 | Narcolepsy |
| G47.411 | Narcolepsy with cataplexy |
| G47.419 | Narcolepsy without cataplexy |
| G47.42 | Narcolepsy in conditions classified elsewhere |
| G47.421 | Narcolepsy in conditions classified elsewhere with cataplexy |
| G47.429 | Narcolepsy in conditions classified elsewhere without cataplexy |
Formulary Reference Tool