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NINJACOF-D (pyrilamine maleate/pseudoephedrine HCl/chlophedianol HCl)
- Cold symptoms
- Allergic rhinitis
- Cough
- Nasal congestion
- Rhinorrhea
- Vasomotor rhinitis
12.5 mg-30 mg-12.5 mg/5 mL oral liquid
- Dosage information is not available
- isocarboxazid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- tranylcypromine
Contraindicated
- Azilect
- bromocriptine
- cabergoline
- Cafergot
- Cycloset
- D.h.e.45
- dihydroergotamine
- Eldepryl
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- linezolid
- methylergonovine
- Migergot
- Migranal
- Parlodel
- rasagiline
- selegiline HCl
- Zelapar
- Zyvox
Severe
Moderate
- methyldopa
- methyldopa-hydrochlorothiazide
- methyldopate
- reserpine
- Angle-closure glaucoma
- Severe coronary artery disease
- Severe uncontrolled hypertension
- Urinary retention
Contraindicated
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Chronic idiopathic constipation
- Diabetes mellitus
- Hypertension
- Hyperthyroidism
- Stenosing peptic ulcer
- Urinary retention
Severe
Moderate
- Debilitation
- Hypertension
- Hyperthyroidism
- Ocular hypertension
NINJACOF-D (pyrilamine maleate/pseudoephedrine HCl/chlophedianol HCl)
- Cold symptoms
- Allergic rhinitis
- Cough
- Nasal congestion
- Rhinorrhea
- Vasomotor rhinitis
- None
- Abdominal pain with cramps
- Drowsy
- Headache disorder
- Insomnia
- Thick bronchial secretions
More Frequent
Severe
Less Severe
- None
- Agitation
- Anorexia
- Dizziness
- Drowsy
- Dysuria
- General weakness
- Nausea
- Nervousness
- Pallor
- Tachycardia
- Tremor
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute generalized exanthematous pustulosis
- Blood dyscrasias
- Dyspnea
- Hallucinations
- Hypertension
- Ischemic colitis
- Seizure disorder
- Urticaria
- Vomiting
Less Severe
- Abdominal pain with cramps
- Acute confusion
- Anorexia
- Blurred vision
- Cardiac arrhythmia
- Dizziness
- Drowsy
- Dry nose
- Dry throat
- Dyspepsia
- Dysuria
- Excitement
- Hallucinations
- Hyperhidrosis
- Irritability
- Nausea
- Nervousness
- Nightmares
- Palpitations
- Skin photosensitivity
- Skin rash
- Symptoms of anxiety
- Tachycardia
- Tinnitus
- Vertigo
- Visual changes
- Vomiting
- Xerostomia
Contraindicated
Chlophedianol
Risk of CNS effects. Not recommended age < 6 years unless clinician consult.
High risk of adverse CNS effects. Not recommended for use age < 6 years.
Possible CNS excitation and seizure risk in newborns.
Do not use in pediatrics <6 years of age unless clinician consultation.
- 1 Day – 6 Years
- 1 Risk of CNS effects. Not recommended age < 6 years unless clinician consult.
- 1 Day – 29 Days
- 1 Risk of CNS effects. Not recommended age < 6 years unless clinician consult.
- 30 Days – 6 Years
- 1 Risk of CNS effects. Not recommended age < 6 years unless clinician consult.
Pseudoephedrine (Immed. Release)
Risk of CNS effects. Not recommended age < 6 years unless clinician consult.
High risk of adverse CNS effects. Not recommended for use age < 6 years.
Possible CNS excitation and seizure risk in newborns.
Do not use in pediatrics <6 years of age unless clinician consultation.
- 1 Day – 6 Years
- 1 High risk of adverse CNS effects. Not recommended for use age < 6 years.
- 1 Day – 29 Days
- 1 High risk of adverse CNS effects. Not recommended for use age < 6 years.
- 30 Days – 6 Years
- 1 High risk of adverse CNS effects. Not recommended for use age < 6 years.
Pyrilamine
Risk of CNS effects. Not recommended age < 6 years unless clinician consult.
High risk of adverse CNS effects. Not recommended for use age < 6 years.
Possible CNS excitation and seizure risk in newborns.
Do not use in pediatrics <6 years of age unless clinician consultation.
- 1 Day – 6 Years
- 1 Possible CNS excitation and seizure risk in newborns.
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
- 1 Day – 29 Days
- 1 Possible CNS excitation and seizure risk in newborns.
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
- 30 Days – 6 Years
- 1 Possible CNS excitation and seizure risk in newborns.
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
Severe Precaution
None
Management or Monitoring Precaution
None
Chlophedianol
- Severity Level:
C
- Additional Notes: Only available in combination products that are assigned fda category c.
Pseudoephedrine
- Severity Level:
C
- Additional Notes: Fda c w/combo prod; poss risk of gastroschisis/sia with 1st trimester exposure
Pyrilamine
- Severity Level:
2
- Additional Notes: No fda category; incr risk of retrolental fibroplasia seen in premature infants
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Chlophedianol
Insufficient data available.
May decrease milk supply, and cause irritability
Use is not recommended; may cause unusual excitement or irritability
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available. |
Pseudoephedrine
Insufficient data available.
May decrease milk supply, and cause irritability
Use is not recommended; may cause unusual excitement or irritability
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Drug shown to have adverse effect | May decrease milk supply, and cause irritability |
Pyrilamine
Insufficient data available.
May decrease milk supply, and cause irritability
Use is not recommended; may cause unusual excitement or irritability
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Drug shown to have adverse effect | Use is not recommended; may cause unusual excitement or irritability |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Pseudoephedrine
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating antihistamine preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | Y | N | N |
BEERS: N HEDIS: N STOPP: N
Pyrilamine
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating antihistamine preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- None
| Allergic rhinitis | |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| Cold symptoms | |
| J00 | Acute nasopharyngitis [common cold] |
| Cough | |
| R05 | Cough |
| Nasal congestion | |
| R09.81 | Nasal congestion |
| Rhinorrhea | |
| R09.82 | Postnasal drip |
| Vasomotor rhinitis | |
| J30.0 | Vasomotor rhinitis |
| 0-9 | A-Z |
|---|---|
| J00 | Acute nasopharyngitis [common cold] |
| J30.0 | Vasomotor rhinitis |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| R05 | Cough |
| R09.81 | Nasal congestion |
| R09.82 | Postnasal drip |
Formulary Reference Tool