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Drug overview for SPS (WITH SORBITOL) (sodium polystyrene sulfonate/sorbitol solution):
Generic name: SODIUM POLYSTYRENE SULFONATE/SORBITOL SOLUTION (SOE-dee-um POL-ee-STYE-reen SUL-foe-nate)
Drug class: Potassium-Removing Resins
Therapeutic class: Electrolyte Balance-Nutritional Products
Sodium polystyrene sulfonate is a sulfonated cation-exchange resin that is used for the removal of excess potassium.
No enhanced Uses information available for this drug.
Generic name: SODIUM POLYSTYRENE SULFONATE/SORBITOL SOLUTION (SOE-dee-um POL-ee-STYE-reen SUL-foe-nate)
Drug class: Potassium-Removing Resins
Therapeutic class: Electrolyte Balance-Nutritional Products
Sodium polystyrene sulfonate is a sulfonated cation-exchange resin that is used for the removal of excess potassium.
No enhanced Uses information available for this drug.
DRUG IMAGES
SPS 30 GM/120 ML ENEMA SUSP
The following indications for SPS (WITH SORBITOL) (sodium polystyrene sulfonate/sorbitol solution) have been approved by the FDA:
Indications:
Hyperkalemia
Professional Synonyms:
Hyperpotassemia
Indications:
Hyperkalemia
Professional Synonyms:
Hyperpotassemia
The following dosing information is available for SPS (WITH SORBITOL) (sodium polystyrene sulfonate/sorbitol solution):
No enhanced Dosing information available for this drug.
No enhanced Administration information available for this drug.
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| SPS 30 GM/120 ML ENEMA SUSP | Maintenance | Adults insert 120 milliliters (30 gram) by rectal route every 6 hours |
No generic dosing information available.
The following drug interaction information is available for SPS (WITH SORBITOL) (sodium polystyrene sulfonate/sorbitol solution):
There are 0 contraindications.
There are 2 severe interactions.
These drug interactions can produce serious consequences in most patients. Actions required for severe interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration scheduling, and providing additional patient monitoring. Review the full interaction monograph for more information.
| Drug Interaction | Drug Names |
|---|---|
| Potassium Supplements/Potassium Binders SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Patiromer, sodium polystyrene sulfonate and sodium zirconium cyclosilicate bind to potassium.(1-3) CLINICAL EFFECTS: Concurrent use of potassium supplements and patiromer, sodium polystyrene sulfonate or sodium zirconium cyclosilicate may decrease the effectiveness of both agents. PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Patients should normally not receive potassium supplements and patiromer, sodium polystyrene sulfonate or sodium zirconium cyclosilicate concurrently.(1-3) Patiromer, sodium polystyrene sulfonate or sodium zirconium cyclosilicate are indicated for management of hyperkalemia. Consider discontinuing or holding potassium supplements in patients who develop hyperkalemia requiring treatment. DISCUSSION: Patiromer, sodium polystyrene sulfonate and sodium zirconium cyclosilicate are indicated for hyperkalemia. Consider discontinuing or holding potassium supplements in patients receiving sodium polystyrene sulfonate or sodium zirconium cyclosilicate. |
DEXTROSE 5%-ELECTROLYTE #48, EFFER-K, K-PHOS NO.2, K-PHOS ORIGINAL, KCL-D5W-0.2% NACL, KCL-D5W-0.225% NACL, KCL-D5W-0.45% NACL, KCL-D5W-0.9% NACL, KLOR-CON, KLOR-CON 10, KLOR-CON 8, KLOR-CON M10, KLOR-CON M15, KLOR-CON M20, KLOR-CON-EF, POKONZA, POTASSIUM ACETATE, POTASSIUM CHLORIDE, POTASSIUM CHLORIDE IN D5LR, POTASSIUM CHLORIDE-0.45% NACL, POTASSIUM CHLORIDE-0.9% NACL, POTASSIUM CHLORIDE-DEXTROSE 5%, POTASSIUM CHLORIDE-WATER, POTASSIUM CL-LIDOCAINE-NS, POTASSIUM PHOSPHATE, POTASSIUM PHOSPHATE-0.9% NACL, POTASSIUM PHOSPHATES |
| Sorbitol/Lamivudine SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Sorbitol increases the osmotic pressure in the intestine, resulting in accelerated small intestinal transit time and decreased absorption and bioavailability of lamivudine. CLINICAL EFFECTS: Concurrent administration of sorbitol and lamivudine may result in decreased clinical efficacy of lamivudine.(1) Reduction in lamivudine exposure is sorbitol dose-dependent. PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: The manufacturer of lamivudine states that the concurrent use of lamivudine and sorbitol should be avoided.(1) Consider more frequent monitoring of HBV viral load when chronic coadministration cannot be avoided. DISCUSSION: In an open label, randomized sequence, 4-period, crossover trial in 16 healthy adults, coadministration of a single dose of lamivudine (300 mg) with sorbitol (3.2 grams) resulted in a dose-dependent decrease of lamivudine's area-under-the-curve (AUC(0-24), AUC infinity) and maximum concentration (Cmax) of 20%, 28%, and 28%. A single dose of lamivudine with sorbitol (10.2 grams) resulted in a decrease of lamivudine's AUC and Cmax of 39%, 52%, and 52%. A single dose of lamivudine with sorbitol (13.4 grams) resulted in a decrease of lamivudine's AUC and Cmax of 36%, 55%, and 55%.(1) |
ABACAVIR-LAMIVUDINE, CIMDUO, DELSTRIGO, DOVATO, EFAVIRENZ-LAMIVU-TENOFOV DISOP, EPIVIR, LAMIVUDINE, LAMIVUDINE HBV, LAMIVUDINE-ZIDOVUDINE, SYMFI, SYMFI LO, TRIUMEQ, TRIUMEQ PD |
There are 2 moderate interactions.
The clinician should assess the patient’s characteristics and take action as needed. Actions required for moderate interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration.
| Drug Interaction | Drug Names |
|---|---|
| Thyroid Preparations/Polystyrene Sulfonate SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Polystyrene sulfonate may bind and delay or prevent the absorption of thyroid preparations from the gastrointestinal tract.(1) CLINICAL EFFECTS: Simultaneous administration of polystyrene sulfonate may result in decreased levels of and effectiveness from thyroid preparations.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: The US manufacturer of levothyroxine states that levothyroxine should be administered at least 4 hours apart from polystyrene sulfonate.(1) DISCUSSION: Because polystyrene sulfonate may bind and delay or prevent the absorption of levothyroxine from the gastrointestinal tract, the US manufacturer of levothyroxine states that levothyroxine should be administered at least 4 hours apart from polystyrene sulfonate.(1) |
ADTHYZA, ARMOUR THYROID, CYTOMEL, ERMEZA, EUTHYROX, LEVO-T, LEVOTHYROXINE SODIUM, LEVOTHYROXINE SODIUM DILUTION, LEVOXYL, LIOTHYRONINE SODIUM, NIVA THYROID, NP THYROID, PCCA T3 SODIUM DILUTION, PCCA T4 SODIUM DILUTION, RENTHYROID, SYNTHROID, THYQUIDITY, THYROID, TIROSINT, TIROSINT-SOL, UNITHROID |
| Lithium/Polystyrene Sulfonate SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Polystyrene sulfonate may bind and delay or prevent the absorption of lithium from the gastrointestinal tract.(1) CLINICAL EFFECTS: Simultaneous administration of polystyrene sulfonate may result in decreased levels of and effectiveness from lithium.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: The US manufacturer of sodium polystyrene sulfonate states that oral medications should be administered at least 3 hours apart from polystyrene sulfonate. Patients with gastroparesis may require a 6 hour separation. If concurrent therapy is warranted, consider monitoring lithium levels and clinical response.(1) DISCUSSION: Because polystyrene sulfonate may bind and delay or prevent the absorption of lithium from the gastrointestinal tract, the US manufacturer of sodium polystyrene sulfonate states that lithium should be administered at least 3 hours apart from polystyrene sulfonate.(1) |
LITHIUM CARBONATE, LITHIUM CARBONATE ER, LITHIUM CITRATE, LITHIUM CITRATE TETRAHYDRATE, LITHOBID |
The following contraindication information is available for SPS (WITH SORBITOL) (sodium polystyrene sulfonate/sorbitol solution):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 9 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Chronic idiopathic constipation |
| Colonic necrosis |
| Fecal impaction |
| Gastrointestinal hypomotility |
| Gastrointestinal obstruction |
| Hypokalemia |
| Ileus |
| Inflammatory bowel disease |
| Ischemic colitis |
There are 5 severe contraindications.
Adequate patient monitoring is recommended for safer drug use.
| Severe List |
|---|
| Absence of bowel sounds |
| Alkalosis |
| Gastrointestinal hemorrhage |
| Gastrointestinal tract surgery |
| Prolonged QT interval |
There are 8 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| Cardiac arrhythmia |
| Edema |
| Hypocalcemia |
| Hypomagnesemia |
| Hypovolemia |
| Kidney disease with reduction in glomerular filtration rate (GFr) |
| Severe chronic heart failure |
| Severe uncontrolled hypertension |
The following adverse reaction information is available for SPS (WITH SORBITOL) (sodium polystyrene sulfonate/sorbitol solution):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 11 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. |
Fecal impaction Hypocalcemia Hypokalemia |
| Rare/Very Rare |
|---|
|
Alkalosis Bronchitis Gastrointestinal concretion Gastrointestinal hemorrhage Gastrointestinal perforation Gastrointestinal ulcer Intestinal ischemic necrosis Ischemic colitis |
There are 5 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Anorexia Constipation Nausea Vomiting |
None. |
| Rare/Very Rare |
|---|
|
Diarrhea |
The following precautions are available for SPS (WITH SORBITOL) (sodium polystyrene sulfonate/sorbitol solution):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
No enhanced Pregnancy information available for this drug.
No enhanced Lactation information available for this drug.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for SPS (WITH SORBITOL) (sodium polystyrene sulfonate/sorbitol solution):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for SPS (WITH SORBITOL) (sodium polystyrene sulfonate/sorbitol solution)'s list of indications:
| Hyperkalemia | |
| E87.5 | Hyperkalemia |
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