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Drug overview for ENULOSE (lactulose):
Generic name: LACTULOSE (LACK-tew-lohss)
Drug class: Laxatives
Therapeutic class: Gastrointestinal Therapy Agents
Lactulose, a synthetic derivative of lactose, is an ammonia detoxicant.
No enhanced Uses information available for this drug.
Generic name: LACTULOSE (LACK-tew-lohss)
Drug class: Laxatives
Therapeutic class: Gastrointestinal Therapy Agents
Lactulose, a synthetic derivative of lactose, is an ammonia detoxicant.
No enhanced Uses information available for this drug.
DRUG IMAGES
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The following indications for ENULOSE (lactulose) have been approved by the FDA:
Indications:
Constipation
Hepatic encephalopathy
Hyperammonemia
Professional Synonyms:
Abnormally elevated blood ammonia
Ammonemia
Portal systemic encephalopathy
Indications:
Constipation
Hepatic encephalopathy
Hyperammonemia
Professional Synonyms:
Abnormally elevated blood ammonia
Ammonemia
Portal systemic encephalopathy
The following dosing information is available for ENULOSE (lactulose):
Each 15 mL of commercially available lactulose solution provides approximately 10 g of the drug; corresponding doses provided by 2.5, 5, 7.5, 10, 30, 40, 45, 90, 150, and 300 mL of the commercial solution are approximately 1.67,
3.3, 5, 6.67, 20, 27, 30, 60, 100, and 200 g, respectively. Following reconstitution of the oral powder as directed, a 10 or 20 g dose is provided by the total volume.
3.3, 5, 6.67, 20, 27, 30, 60, 100, and 200 g, respectively. Following reconstitution of the oral powder as directed, a 10 or 20 g dose is provided by the total volume.
No enhanced Administration information available for this drug.
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| ENULOSE 10 GM/15 ML SOLUTION | Maintenance | Adults take 30 milliliters (20 gram) by oral route 3 times per day |
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| LACTULOSE 10 GM/15 ML SOLUTION | Maintenance | Adults take 30 milliliters (20 gram) by oral route 3 times per day |
| LACTULOSE 10 GM/15 ML SOLN CUP | Maintenance | Adults take 30 milliliters (20 gram) by oral route 3 times per day |
| LACTULOSE 20 GM/30 ML SOLN CUP | Maintenance | Adults take 30 milliliters (20 gram) by oral route 3 times per day |
The following drug interaction information is available for ENULOSE (lactulose):
There are 0 contraindications.
There are 0 severe interactions.
There are 0 moderate interactions.
The following contraindication information is available for ENULOSE (lactulose):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 4 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Appendicitis |
| Galactosemia |
| Gastrointestinal obstruction |
| Glucose-galactose malabsorption |
There are 0 severe contraindications.
There are 1 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| Diabetes mellitus |
The following adverse reaction information is available for ENULOSE (lactulose):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 0 severe adverse reactions.
There are 4 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. |
Abdominal pain with cramps Diarrhea Flatulence Polydipsia |
| Rare/Very Rare |
|---|
| None. |
The following precautions are available for ENULOSE (lactulose):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
Use of lactulose during pregnancy has not been studied in humans. Reproduction studies in rats, mice, and rabbits receiving oral lactulose doses up to 6 times the usual human oral dose have not revealed evidence of harm to the fetus. Lactulose should be used during pregnancy only when clearly needed.
It is not known if lactulose is distributed into milk. The drug should be used with caution in nursing women.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for ENULOSE (lactulose):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for ENULOSE (lactulose)'s list of indications:
| Constipation | |
| K59.0 | Constipation |
| K59.00 | Constipation, unspecified |
| K59.01 | Slow transit constipation |
| K59.03 | Drug induced constipation |
| K59.04 | Chronic idiopathic constipation |
| K59.09 | Other constipation |
| Hepatic encephalopathy | |
| B15.0 | Hepatitis A with hepatic coma |
| B16.0 | Acute hepatitis B with delta-agent with hepatic coma |
| B16.2 | Acute hepatitis B without delta-agent with hepatic coma |
| B17.11 | Acute hepatitis C with hepatic coma |
| B19.0 | Unspecified viral hepatitis with hepatic coma |
| B19.11 | Unspecified viral hepatitis B with hepatic coma |
| B19.21 | Unspecified viral hepatitis C with hepatic coma |
| K70.41 | Alcoholic hepatic failure with coma |
| K71.11 | Toxic liver disease with hepatic necrosis, with coma |
| K72.01 | Acute and subacute hepatic failure with coma |
| K72.11 | Chronic hepatic failure with coma |
| K72.90 | Hepatic failure, unspecified without coma |
| K72.91 | Hepatic failure, unspecified with coma |
| K76.82 | Hepatic encephalopathy |
| Hyperammonemia | |
| B15.0 | Hepatitis A with hepatic coma |
| B16.0 | Acute hepatitis B with delta-agent with hepatic coma |
| B16.2 | Acute hepatitis B without delta-agent with hepatic coma |
| B17.11 | Acute hepatitis C with hepatic coma |
| B19.0 | Unspecified viral hepatitis with hepatic coma |
| B19.11 | Unspecified viral hepatitis B with hepatic coma |
| B19.21 | Unspecified viral hepatitis C with hepatic coma |
| D81.810 | Biotinidase deficiency |
| E71.110 | Isovaleric acidemia |
| E71.121 | Propionic acidemia |
| E72.20 | Disorder of urea cycle metabolism, unspecified |
| E72.21 | Argininemia |
| E72.22 | Arginosuccinic aciduria |
| E72.23 | Citrullinemia |
| E72.29 | Other disorders of urea cycle metabolism |
| E72.4 | Disorders of ornithine metabolism |
| K72.91 | Hepatic failure, unspecified with coma |
| P74.6 | Transitory hyperammonemia of newborn |
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