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SPIRIVA RESPIMAT (TIOTROPIUM BROMIDE)
- Bronchospasm prevention with COPD
- Maintenance therapy for asthma
- Prevention of bronchospasm with chronic bronchitis
- Prevention of bronchospasms with emphysema
1.25 mcg/actuation solution for inhalation
- Inhale 2 puffs (2.5 mcg) by inhalation route once daily
2.5 mcg/actuation solution for inhalation
- Inhale 2 puffs (5 mcg) by inhalation route once daily at the same time each day
Bronchospasm prevention with COPD
- Inhale 2 puffs (5 mcg) by inhalation route once daily at the same time each day
Maintenance therapy for asthma
- Inhale 2 puffs (2.5 mcg) by inhalation route once daily
Prevention of bronchospasm with chronic bronchitis
- Inhale 2 puffs (5 mcg) by inhalation route once daily at the same time each day
Prevention of bronchospasms with emphysema
- Inhale 2 puffs (5 mcg) by inhalation route once daily at the same time each day
- None
Contraindicated
- pramlintide
- Symlinpen 120
- Symlinpen 60
Severe
Moderate
- K-tab
- Klor-con
- Klor-con 10
- Klor-con M10
- Klor-con M15
- Klor-con M20
- Medi-lyte
- potassium chloride
- potassium citrate
- potassium Cl-calcium phos-mag
- sodium Cl-potassium chloride
- Thermotabs
- Urocit-k 10
- Urocit-k 15
- Urocit-k 5
- None
Contraindicated
- None
Severe
Moderate
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Urinary retention
SPIRIVA RESPIMAT (TIOTROPIUM BROMIDE)
- Bronchospasm prevention with COPD
- Maintenance therapy for asthma
- Prevention of bronchospasm with chronic bronchitis
- Prevention of bronchospasms with emphysema
- None
- Bronchitis
- Cough
- Headache disorder
- Pharyngitis
- Sinusitis
- Xerostomia
More Frequent
Severe
Less Severe
- Chest pain
- Epistaxis
- Arthritis
- Constipation
- Dizziness
- Gastroesophageal reflux disease
- Oral candidiasis
- Palpitations
- Pruritus of skin
- Rhinitis
- Skin rash
- Urinary tract infection
- Voice change
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Aggravated glaucoma
- Angina
- Angioedema
- Atrial fibrillation
- Dehydration
- Glaucoma
- Hypersensitivity drug reaction
- Hypertension
- Ileus
- Infection
- Ocular hypertension
- Paroxysmal supraventricular tachycardia
Less Severe
- Arthralgias
- Blurred vision
- Dry skin
- Dysphagia
- Dysuria
- Fever
- Gingivitis
- Glossitis
- Insomnia
- Laryngitis
- Muscle spasm
- Paradoxical bronchospasm
- Skin ulcer
- Sore throat
- Stomatitis
- Tachycardia
- Tonsillitis
- Urinary retention
- Urticaria
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Tiotropium
Efficacy for treating asthma not established age < 6 years.
- 1 Day – 6 Years
- Efficacy for treating asthma not established age < 6 years.
Tiotropium
- Severity Level:
2
- Additional Notes: Poorly controlled asthma is associated with preeclampsia and low birth weight
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Tiotropium
Insufficient human data
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Tiotropium Bromide
Urogenital-Use caution in men with benign prostatic hyperplasia; may decrease urinary flow and cause urinary retention. Incidence of urinary tract infection increases with age. Other-Use caution in elderly with narrow angle glaucoma. Gastrointestinal-Anticholinergic effects may worsen constipation in predisposed elderly.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- None
| Bronchospasm prevention with COPD | |
| J44 | Other chronic obstructive pulmonary disease |
| J44.9 | Chronic obstructive pulmonary disease, unspecified |
| Maintenance therapy for asthma | |
| J45 | Asthma |
| J45.2 | Mild intermittent asthma |
| J45.20 | Mild intermittent asthma, uncomplicated |
| J45.3 | Mild persistent asthma |
| J45.30 | Mild persistent asthma, uncomplicated |
| J45.4 | Moderate persistent asthma |
| J45.40 | Moderate persistent asthma, uncomplicated |
| J45.5 | Severe persistent asthma |
| J45.50 | Severe persistent asthma, uncomplicated |
| J45.9 | Other and unspecified asthma |
| J45.90 | Unspecified asthma |
| J45.909 | Unspecified asthma, uncomplicated |
| Prevention of bronchospasm with chronic bronchitis | |
| J41 | Simple and mucopurulent chronic bronchitis |
| J41.0 | Simple chronic bronchitis |
| J41.1 | Mucopurulent chronic bronchitis |
| J41.8 | Mixed simple and mucopurulent chronic bronchitis |
| J42 | Unspecified chronic bronchitis |
| J44 | Other chronic obstructive pulmonary disease |
| J44.9 | Chronic obstructive pulmonary disease, unspecified |
| Prevention of bronchospasms with emphysema | |
| J43 | Emphysema |
| J43.0 | Unilateral pulmonary emphysema [macleod's syndrome] |
| J43.1 | Panlobular emphysema |
| J43.2 | Centrilobular emphysema |
| J43.8 | Other emphysema |
| J43.9 | Emphysema, unspecified |
| J44 | Other chronic obstructive pulmonary disease |
| J44.9 | Chronic obstructive pulmonary disease, unspecified |
| 0-9 | A-Z |
|---|---|
| J41 | Simple and mucopurulent chronic bronchitis |
| J41.0 | Simple chronic bronchitis |
| J41.1 | Mucopurulent chronic bronchitis |
| J41.8 | Mixed simple and mucopurulent chronic bronchitis |
| J42 | Unspecified chronic bronchitis |
| J43 | Emphysema |
| J43.0 | Unilateral pulmonary emphysema [macleod's syndrome] |
| J43.1 | Panlobular emphysema |
| J43.2 | Centrilobular emphysema |
| J43.8 | Other emphysema |
| J43.9 | Emphysema, unspecified |
| J44 | Other chronic obstructive pulmonary disease |
| J44 | Other chronic obstructive pulmonary disease |
| J44 | Other chronic obstructive pulmonary disease |
| J44.9 | Chronic obstructive pulmonary disease, unspecified |
| J44.9 | Chronic obstructive pulmonary disease, unspecified |
| J44.9 | Chronic obstructive pulmonary disease, unspecified |
| J45 | Asthma |
| J45.2 | Mild intermittent asthma |
| J45.20 | Mild intermittent asthma, uncomplicated |
| J45.3 | Mild persistent asthma |
| J45.30 | Mild persistent asthma, uncomplicated |
| J45.4 | Moderate persistent asthma |
| J45.40 | Moderate persistent asthma, uncomplicated |
| J45.5 | Severe persistent asthma |
| J45.50 | Severe persistent asthma, uncomplicated |
| J45.9 | Other and unspecified asthma |
| J45.90 | Unspecified asthma |
| J45.909 | Unspecified asthma, uncomplicated |
Formulary Reference Tool