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GILOTRIF (AFATINIB DIMALEATE)
- EGFR positive non-small cell lung cancer
- Squamous cell carcinoma of lung
20 mg tablet
- 2 tablets (40 mg) by oral route once daily at least 1 hour before or 2 hours after meals
30 mg tablet
- 1 tablet (30 mg) by oral route once daily at least 1 hour beforeor 2 hours after meals
40 mg tablet
- 1 tablet (40 mg) by oral route once daily at least 1 hour beforeor 2 hours after meals
EGFR positive non-small cell lung cancer
- 1 tablet (20 mg) by oral route once daily at least 1 hour beforeor 2 hours after meals
- 1 tablet (30 mg) by oral route once daily at least 1 hour beforeor 2 hours after meals
- 1 tablet (40 mg) by oral route once daily at least 1 hour beforeor 2 hours after meals
- 2 tablets (40 mg) by oral route once daily at least 1 hour before or 2 hours after meals
Squamous cell carcinoma of lung
- 1 tablet (20 mg) by oral route once daily at least 1 hour beforeor 2 hours after meals
- 1 tablet (30 mg) by oral route once daily at least 1 hour beforeor 2 hours after meals
- 1 tablet (40 mg) by oral route once daily at least 1 hour beforeor 2 hours after meals
- 2 tablets (40 mg) by oral route once daily at least 1 hour before or 2 hours after meals
- None
Contraindicated
- None
Severe
Moderate
- amiodarone
- amoxicil-clarithromy-lansopraz
- Astagraf Xl
- Atripla
- azithromycin
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- Calan
- Calan Sr
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- carvedilol
- carvedilol phosphate
- Cerebyx
- clarithromycin
- Cold & Flu Fighter
- Cordarone
- Coreg
- Coreg Cr
- cyclosporine
- cyclosporine modified
- dextromethorphan-quinidine
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- dronedarone
- efavirenz
- efavirenz-emtricitabin-tenofov
- Epitol
- Equetro
- erythromycin
- erythromycin-sulfisoxazole
- Fatigue Relief Complex
- felodipine
- fosphenytoin
- Gengraf
- Hecoria
- Incivek
- isoniazid-rifamp-pyrazinamide
- itraconazole
- Kaletra
- ketoconazole
- lapatinib
- lopinavir-ritonavir
- Multaq
- Neoral
- Norvir
- Norvir Soft Gelatin
- Nuedexta
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- Pacerone
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Prevpac
- Prograf
- quinidine gluconate
- quinidine sulfate
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- ritonavir
- Sandimmune
- Sporanox
- Sporanox Pulsepak
- St. John's wort
- Sustiva
- tacrolimus
- Tarka
- Tegretol
- Tegretol Xr
- telaprevir
- trandolapril-verapamil
- Tykerb
- verapamil
- Verelan
- Verelan Pm
- vit C-St. John wort-elder-hb30
- Women's Complex
- Zithromax
- Zithromax Tri-pak
- Zithromax Z-pak
- Zmax
- Gastrointestinal perforation
- Interstitial lung disease
- Lactating mother
Contraindicated
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Diverticulitis of gastrointestinal tract
- Drug-induced hepatitis
- Gastrointestinal ulcer
- Left ventricular failure
- Pregnancy
- Severe diarrhea
Severe
Moderate
- Keratitis
GILOTRIF (AFATINIB DIMALEATE)
- EGFR positive non-small cell lung cancer
- Squamous cell carcinoma of lung
- Abnormal hepatic function tests
- Acneiform eruption
- Anorexia
- Diarrhea
- Dry skin
- Erythema
- Nausea
- Paronychia
- Pruritus of skin
- Skin rash
- Stomatitis
- Vomiting
More Frequent
Severe
Less Severe
- Anemia
- Cellulitis
- Dehydration
- Gastrointestinal perforation
- Increased alanine transaminase
- Interstitial lung disease
- Left ventricular failure
- Leukopenia
- Myocardial dysfunction
- Palmar-plantar erythrodysesthesia
- Severe diarrhea
- Abdominal distension
- Acute abdominal pain
- Alopecia
- Arthralgias
- Back pain
- Blepharitis
- Cheilitis
- Conjunctivitis
- Constipation
- Cough
- Cystitis
- Dizziness
- Dysesthesia
- Dysphagia
- Epistaxis
- Fever
- Gastritis
- Gastroesophageal reflux disease
- Glossitis
- Headache disorder
- Hirsutism
- Muscle spasm
- Musculoskeletal pain
- Myalgias
- Nail disorders
- Pharyngitis
- Phototoxicity
- Proteinuria
- Rectal pain
- Rhinorrhea
- Skin fissure
- Skin pigmentation enhancement
- Upper respiratory infection
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute respiratory insufficiency
- Bacterial sepsis
- Bullous dermatitis
- Dyspnea
- Exfoliative dermatitis
- Hepatic failure
- Hypersensitivity pneumonitis
- Hypokalemia
- Interstitial pneumonitis
- Keratitis
- Pancreatitis
- Pneumonia
- Stevens-johnson syndrome
- Toxic epidermal necrolysis
Less Severe
- Fatigue
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Afatinib
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Afatinib
- Severity Level:
D
- Additional Notes: Fetal toxicity possible due to pharmacology; abortifacient in animals
Contraindicated
Afatinib
Manufacturer does not recommend, potential for toxicity
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Manufacturer does not recommend, potential for toxicity |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| EGFR positive non-small cell lung cancer | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
| Squamous cell carcinoma of lung | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| 0-9 | A-Z |
|---|---|
| C34 | Malignant neoplasm of bronchus and lung |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
Formulary Reference Tool