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APTIVUS (TIPRANAVIR/VITAMIN E TPGS)
- HIV infection
100 mg/mL oral solution
- 5 milliliters (500 mg) by oral route 2 times per day
250 mg capsule
- 2 capsules (500 mg) by oral route 2 times per day
HIV infection
- 2 capsules (500 mg) by oral route 2 times per day
- 5 milliliters (500 mg) by oral route 2 times per day
- 5 milliliters (500 mg) by oral route 2 times per day in combination with ritonavir
- 2 capsules (500 mg) by oral route 2 times per day in combinationwith ritonavir
- Advicor
- alfuzosin
- Altoprev
- amiodarone
- amiodarone in dextrose,iso-osm
- avanafil
- B cplx-C-St.Johnwrt-K.&S.ginsg
- bromocriptine
- cabergoline
- Cafergot
- calcium-mag-B complex-D3-hrb61
- Camptosar
- Cold & Flu Fighter
- Cordarone
- Cycloset
- D.h.e.45
- dextromethorphan-quinidine
- dihydroergotamine
- dutasteride-tamsulosin
- elvitegr-cobicist-emtric-tenof
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- etravirine
- ezetimibe-simvastatin
- Fatigue Relief Complex
- flecainide
- Flomax
- Intelence
- irinotecan
- isoniazid-rifamp-pyrazinamide
- Jalyn
- Juxtapid
- Kaletra
- lomitapide
- lopinavir-ritonavir
- lovastatin
- methylergonovine
- Mevacor
- midazolam
- midazolam (PF)
- Migergot
- Migranal
- Nexterone
- niacin-lovastatin
- niacin-simvastatin
- Nuedexta
- Orap
- Pacerone
- Parlodel
- pimozide
- propafenone
- quinidine gluconate
- quinidine sulfate
- Rapaflo
- Revatio
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Rythmol
- sildenafil
- silodosin
- Simcor
- simvastatin
- sofosbuvir
- Sovaldi
- St. John's wort
- Stendra
- Stribild
- tamsulosin
- triazolam
- Uroxatral
- vit C-St. John wort-elder-hb30
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Women's Complex
- Zocor
Contraindicated
- abciximab
- Abstral
- Actiq
- Aggrastat In Sodium Chloride
- Alfenta
- alfentanil
- Altavera (28)
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Amethia
- Amethia Lo
- Amethyst
- amlodipine-atorvastatin
- Apri
- Aranelle (28)
- Astagraf Xl
- atorvastatin
- Aubra
- Aviane
- Azurette (28)
- B6-FA-B12-co Q10-herb no.225
- Balziva (28)
- Beauty & Skin Therapy
- Beyaz
- bosentan
- Brevicon (28)
- Briellyn
- Brilinta
- Caduet
- Camila
- Camrese
- Camrese Lo
- Caziant (28)
- Chateal
- cilostazol
- clopidogrel
- colchicine
- colchicine-probenecid
- Colcrys
- Coumadin
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- cyclosporine
- cyclosporine modified
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- Depo-provera
- Depo-subq Provera 104
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- dolutegravir
- drospirenone-e.estradiol-lm.FA
- drospirenone-ethinyl estradiol
- Duragesic
- Elinest
- Emoquette
- Endocet
- Endodan
- Enpresse
- Enskyce
- eptifibatide
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estrostep Fe-28
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- ezetimibe-atorvastatin
- Falmina (28)
- Femcon Fe
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- Fortavit
- Generess Fe
- Gengraf
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- guanfacine
- Healthy Heart Complex
- Heather
- Hecoria
- ibuprofen-oxycodone
- Integrilin
- Introvale
- Intuniv Er
- Invirase
- Jantoven
- Jencycla
- Jentadueto
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kariva (28)
- Kelnor 1/35 (28)
- Kurvelo
- L norgest&E estradiol-E estrad
- Larin 1/20 (21)
- Larin Fe
- Lazanda
- Leena 28
- Lessina
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- linagliptin
- linagliptin-metformin
- Lipitor
- Liptruzet
- Lo Loestrin Fe
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- Loryna (28)
- Loseasonique
- Low-ogestrel (28)
- Lutera (28)
- Lyza
- macitentan
- Marlissa
- Maximum Daily Green
- medroxyprogesterone
- Megavite
- Megavite Golden Years 55+
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- Minastrin 24 Fe
- Mircette (28)
- Mirena
- Modicon (28)
- Mono-linyah
- Mononessa (28)
- MSM-collag-co Q10-herb no.226
- multivit-Fe-min-DNA-RNA-dsup4
- mv-iron-FA-Ca-beepoln-hb 101
- mv-mn-FA-herbs190&215-digest#4
- mv-mn-FA-lycopene-lut-#178herb
- mv-mn-iron-FA-herbal cmplx#190
- My Way
- Mycobutin
- Myzilra
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Neoral
- Nexplanon
- Next Choice One Dose
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Nuvaring
- Ocella
- Ogestrel (28)
- Olysio
- Opsumit
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- Percocet
- Percodan
- Philith
- Pimtrea (28)
- Pirmella
- Plan B One-step
- Plavix
- Pletal
- policosan-inositol niac-garlic
- Policosanol-garlic-niacin
- Portia
- Previfem
- Priftin
- Primlev
- Prograf
- Quartette
- Quasense
- Rapamune
- Reclipsen (28)
- Reopro
- rifabutin
- rifapentine
- Roxicet
- Safyral
- Sandimmune
- saquinavir mesylate
- Seasonique
- simeprevir
- sirolimus
- Skyla
- Sprintec (28)
- Sronyx
- Sublimaze (pf)
- Subsys
- Syeda
- tacrolimus
- temsirolimus
- Tenex
- ticagrelor
- ticlopidine
- Tilia Fe
- tirofiban-0.9% sodium chloride
- Tivicay
- Torisel
- Tracleer
- Tradjenta
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- Trinessa (28)
- Trivora (28)
- Velivet Triphasic Regimen (28)
- Vestura (28)
- Viorele (28)
- Vyfemla (28)
- warfarin
- Wera (28)
- Wymzya Fe
- Xartemis Xr
- Yasmin (28)
- Yaz 28
- Zarah
- Zenchent (28)
- Zenchent Fe
- Zeosa
- Zovia 1/35E (28)
- Zovia 1/50E (28)
Severe
Moderate
- amoxicil-clarithromy-lansopraz
- Belladonna-phenobarbital
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- Cerebyx
- clarithromycin
- Conzip
- Crestor
- Diflucan
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosamprenavir
- fosphenytoin
- itraconazole
- ketoconazole
- Levitra
- Lexiva
- Luminal
- Mysoline
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Prevpac
- primidone
- rosuvastatin
- Sporanox
- Sporanox Pulsepak
- Synapryn
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- Ultracet
- Ultram
- Ultram Er
- vardenafil
- Viagra
- Intracranial bleeding
- Lactating mother
- Severe hepatic disease
Contraindicated
- Chronic hepatitis B
- Chronic hepatitis C
Severe
Moderate
- Diabetes mellitus
- Hemophilia A
- Hemophilia B
- Hypercholesterolemia
- Hypertriglyceridemia
- Increased risk of bleeding
- Increased risk of bleeding due to coagulation disorder
- Invasive surgical procedure
- Major traumatic injury
- Neoplasm of brain
- Open procedure on central nervous system
- Vitamin K deficiency induced hypoprothrombinemia
APTIVUS (TIPRANAVIR/VITAMIN E TPGS)
- HIV infection
- Fever
- Hypercholesterolemia
- Hypertriglyceridemia
- Skin rash
- Abdominal pain with cramps
- Diarrhea
- Fatigue
- Headache disorder
- Maculopapular rash
- Nausea
- Urticaria
- Vomiting
More Frequent
Severe
Less Severe
- Anemia
- Dehydration
- Neutropenic disorder
- Cough
- Epistaxis
- Hemorrhage
- Insomnia
- Myalgias
- Skin photosensitivity
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute hepatic failure
- Acute pancreatitis
- Diabetes mellitus
- Dyspnea
- Hemorrhage
- Hepatitis
- Hyperglycemia
- Hypersensitivity drug reaction
- Intracranial bleeding
- Kidney disease with reduction in GFR
- Peripheral neuropathy
- Platelet aggregation inhibition
- Prolonged QT interval
- Thrombocytopenic disorder
Less Severe
- Abdominal distension
- Abdominal pain with cramps
- Anorexia
- Blurred vision
- Cramps
- Diarrhea
- Dizziness
- Drowsy
- Dyspepsia
- Fat hypertrophy
- Fatigue
- Flatulence
- Flu-like symptoms
- Gastroesophageal reflux disease
- General weakness
- Headache disorder
- Hyperbilirubinemia
- Lipodystrophy associated with HIV
- Malaise
- Mastalgia
- Nausea
- Pruritus of skin
- Skin rash
- Sleep disorder
- Thrombophlebitis
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Tipranavir
Risk-benefit not established in pediatrics age < 2 years.
Increased risk of rash. Consult healthcare provider for severe rash. Adhere carefully to dose calculation and do not exceed adult dose.
- 1 Day – 2 Years
- Risk-benefit not established in pediatrics age < 2 years.
- Increased risk of rash. Consult healthcare provider for severe rash. Adhere carefully to dose calculation and do not exceed adult dose.
- 2 Years – 18 Years
- Risk-benefit not established in pediatrics age < 2 years.
- Increased risk of rash. Consult healthcare provider for severe rash. Adhere carefully to dose calculation and do not exceed adult dose.
Tipranavir
- Severity Level:
2
- Additional Notes: Available human data show no increased risk for major birth defects.
Contraindicated
Tipranavir
Cdc does not recommend breastfeeding in hiv-positive women
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Cdc does not recommend breastfeeding in hiv-positive women |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Tipranavir must be given with ritonavir to work effectively. When these two drugs are combined, there have been rare (sometimes fatal) cases of severe liver problems. Your doctor will monitor you closely and perform simple blood tests while you use this medication, especially if you also have infections that affect the liver (chronic hepatitis B or hepatitis C).<br /><br /> Patients being treated with tipranavir and ritonavir may rarely have a serious (sometimes fatal) bleeding problem in the brain (intracranial hemorrhage). This effect may be due to other drugs you are taking or conditions you may have, so do not stop taking tipranavir and ritonavir without consulting your doctor. Seek immediate medical attention if you develop severe stomach/abdominal pain, unusual tiredness, loss of appetite, dark urine, yellowing of skin or eyes, unusual bleeding or bruising, or mental/mood changes.
| HIV infection | |
| B20 | Human immunodeficiency virus [HIv] disease |
| B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
| O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
| O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
| O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
| O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
| O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
| O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
| O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
| O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
| Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
| 0-9 | A-Z |
|---|---|
| B20 | Human immunodeficiency virus [HIv] disease |
| B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
| O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
| O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
| O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
| O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
| O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
| O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
| O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
| O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
| Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
Formulary Reference Tool