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SUSTIVA (EFAVIRENZ)
- HIV infection
600 mg tablet
- 1 tablet (600 mg) by oral route once daily at bedtime
200 mg capsule
- 3 capsules (600 mg) by oral route once daily
50 mg capsule
- Dosage information is not available
600 mg tablet
- 1 tablet (600 mg) by oral route once daily at bedtime
200 mg capsule
- 3 capsules (600 mg) by oral route once daily
50 mg capsule
- Dosage information is not available
HIV infection
- 3 capsules (600 mg) by oral route once daily
- 1 tablet (600 mg) by oral route once daily
- 3 capsules (600 mg) by oral route once daily at bedtime
- 1 tablet (600 mg) by oral route once daily at bedtime
- B cplx-C-St.Johnwrt-K.&S.ginsg
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cold & Flu Fighter
- elvitegr-cobicist-emtric-tenof
- Epitol
- Equetro
- etravirine
- Fatigue Relief Complex
- Intelence
- St. John's wort
- Stribild
- Tegretol
- Tegretol Xr
- vit C-St. John wort-elder-hb30
- Women's Complex
Contraindicated
- Altavera (28)
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Amethia
- Amethia Lo
- Amethyst
- apixaban
- Apri
- Aranelle (28)
- atazanavir
- Aubra
- Aviane
- axitinib
- Azurette (28)
- Balziva (28)
- bedaquiline
- Beyaz
- boceprevir
- Bosulif
- bosutinib
- Brevicon (28)
- Briellyn
- Camila
- Camrese
- Camrese Lo
- Caziant (28)
- Chateal
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- Depo-provera
- Depo-subq Provera 104
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- dolutegravir
- drospirenone-e.estradiol-lm.FA
- drospirenone-ethinyl estradiol
- Elinest
- Eliquis
- Emoquette
- Enpresse
- Enskyce
- enzalutamide
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estrostep Fe-28
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- Falmina (28)
- Femcon Fe
- Generess Fe
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- guanfacine
- Heather
- Incivek
- Inlyta
- Introvale
- Intuniv Er
- itraconazole
- Jencycla
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kariva (28)
- Kelnor 1/35 (28)
- ketoconazole
- Kurvelo
- L norgest&E estradiol-E estrad
- Larin 1/20 (21)
- Larin Fe
- Leena 28
- Lessina
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- Lo Loestrin Fe
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- Loryna (28)
- Loseasonique
- Low-ogestrel (28)
- Lutera (28)
- Lyza
- Marlissa
- medroxyprogesterone
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- Minastrin 24 Fe
- Mircette (28)
- Mirena
- Modicon (28)
- Mono-linyah
- Mononessa (28)
- My Way
- Myzilra
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Nexplanon
- Next Choice One Dose
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Noxafil
- Nuvaring
- Ocella
- Ogestrel (28)
- Olysio
- Onmel
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- Philith
- Pimtrea (28)
- Pirmella
- Plan B One-step
- Portia
- posaconazole
- Previfem
- Quartette
- Quasense
- Reclipsen (28)
- Reyataz
- rivaroxaban
- Safyral
- Seasonique
- simeprevir
- Sirturo
- Skyla
- Sporanox
- Sporanox Pulsepak
- Sprintec (28)
- Sronyx
- Syeda
- telaprevir
- Tenex
- Tilia Fe
- Tivicay
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- Trinessa (28)
- Trivora (28)
- Velivet Triphasic Regimen (28)
- Vestura (28)
- Vfend
- Vfend Iv
- Victrelis
- Viorele (28)
- voriconazole
- Vyfemla (28)
- Wera (28)
- Wymzya Fe
- Xarelto
- Xtandi
- Yasmin (28)
- Yaz 28
- Zarah
- Zenchent (28)
- Zenchent Fe
- Zeosa
- Zovia 1/35E (28)
- Zovia 1/50E (28)
Severe
Moderate
- afatinib
- amlodipine-atorvastatin
- amoxicil-clarithromy-lansopraz
- atorvastatin
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- Caduet
- Cancidas
- caspofungin
- cilostazol
- clarithromycin
- Crixivan
- Diskets
- Dolophine
- ezetimibe-atorvastatin
- ezetimibe-simvastatin
- fosamprenavir
- Gilotrif
- indinavir
- Invirase
- Kaletra
- Lexiva
- Lipitor
- Liptruzet
- lopinavir-ritonavir
- methadone
- Methadone Intensol
- Methadose
- Mycobutin
- niacin-simvastatin
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Pletal
- Pravachol
- pravastatin
- Prevpac
- rifabutin
- saquinavir mesylate
- Simcor
- simvastatin
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Zocor
- Lactating mother
Contraindicated
- Depression
- Disease of liver
- Manic disorder
- Paranoid disorder
- Suicidal ideation
Severe
Moderate
- Aggressive behavior
- CYp2b6*6/*6 genotype
- Hypercholesterolemia
- Hypertriglyceridemia
- Insomnia
- Seizure disorder
SUSTIVA (EFAVIRENZ)
- HIV infection
- Depression
- Pruritus of skin
- Skin rash
- Concentration difficulty
- Diarrhea
- Dizziness
- Dream disorder
- Drowsy
- Fatigue
- Headache disorder
- Insomnia
- Lipodystrophy associated with HIV
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Hallucinations
- Prolonged QT interval
- Acute abdominal pain
- Dyspepsia
- Hypercholesterolemia
- Hypertriglyceridemia
- Nervousness
- Symptoms of anxiety
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal desquamation
- Abnormal hepatic function tests
- Acute confusion
- Acute hepatic failure
- Acute pancreatitis
- Ataxia
- Behavioral disorders
- Blistering skin
- Catatonia
- Delusional disorder
- Dermal necrosis
- Drug-induced psychosis
- Dysphasia
- Dyspnea
- Encephalopathy
- Erythema multiforme
- Exfoliative dermatitis
- Fever
- Graves' disease
- Guillain-barre syndrome
- Hepatitis
- Manic disorder
- Paranoid disorder
- Paresthesia
- Peripheral neuropathy
- Phototoxicity
- Polymyositis
- Seizure disorder
- Skin ulcer
- Stevens-johnson syndrome
- Suicidal
- Suicidal ideation
- Syncope
- Toxic epidermal necrolysis
- Tremor
- Urticaria
- Visual changes
- Wheezing
Less Severe
- Aggressive behavior
- Agitation
- Anorexia
- Arthralgias
- Constipation
- Cough
- Depersonalization
- Euphoria
- Flushing
- Folliculitis
- General weakness
- Gynecomastia
- Hypesthesia
- Malabsorption states
- Memory impairment
- Mood changes
- Myalgias
- Myopathy
- Palpitations
- Tinnitus
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Efavirenz
Safety and efficacy not evaluated age < 3 months or weight < 3.5 kg. Adequate dosing and anti-viral activity not established.
Increased incidence of rash with severe manifestations in pediatrics. Consider antihistamine prophylaxis prior to initiating treatment.
- 1 Day – 89 Days
- Safety and efficacy not evaluated age < 3 months or weight < 3.5 kg. Adequate dosing and anti-viral activity not established.
- Increased incidence of rash with severe manifestations in pediatrics. Consider antihistamine prophylaxis prior to initiating treatment.
- 90 Days – 18 Years
- Safety and efficacy not evaluated age < 3 months or weight < 3.5 kg. Adequate dosing and anti-viral activity not established.
- Increased incidence of rash with severe manifestations in pediatrics. Consider antihistamine prophylaxis prior to initiating treatment.
Efavirenz
- Severity Level:
2
- Additional Notes: No fda cat;art preg registry data show no increased risk for major birth defects
Contraindicated
Efavirenz
Cdc does not recommend breastfeeding in hiv-positive women
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Cdc does not recommend breastfeeding in hiv-positive women |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| HIV infection | |
| B20 | Human immunodeficiency virus [HIv] disease |
| B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
| O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
| O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
| O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
| O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
| O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
| O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
| O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
| O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
| Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
| 0-9 | A-Z |
|---|---|
| B20 | Human immunodeficiency virus [HIv] disease |
| B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
| O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
| O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
| O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
| O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
| O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
| O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
| O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
| O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
| Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
Formulary Reference Tool