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SPRYCEL (DASATINIB)
- Accelerated phase philadelphia chromosome (+) CML
- Chronic phase philadelphia chromosome (+) CML
- Lymphoid blast phase philadelphia chromosome (+) CML
- Myeloid blast phase philadelphia chromosome (+) CML
- Philadelphia chromosome positive ALL
100 mg tablet
- 1 tablet (100 mg) by oral route once daily
140 mg tablet
- 1 tablet (140 mg) by oral route once daily
20 mg tablet
- 1 tablet (20 mg) by oral route once daily
50 mg tablet
- 2 tablets (100 mg) by oral route once daily
70 mg tablet
- 2 tablets (140 mg) by oral route once daily
80 mg tablet
- 1 tablet (80 mg) by oral route once daily
Accelerated phase philadelphia chromosome (+) CML
- 2 tablets (40 mg) by oral route once daily
- 1 tablet (80 mg) by oral route once daily
- 2 tablets (140 mg) by oral route once daily
- 1 tablet (140 mg) by oral route once daily
Chronic phase philadelphia chromosome (+) CML
- 1 tablet (20 mg) by oral route once daily
- 1 tablet (50 mg) by oral route once daily
- 1 tablet (80 mg) by oral route once daily
- 1 tablet (100 mg) by oral route once daily
- 2 tablets (100 mg) by oral route once daily
- 2 tablets (140 mg) by oral route once daily
- 1 tablet (140 mg) by oral route once daily
Lymphoid blast phase philadelphia chromosome (+) CML
- 2 tablets (40 mg) by oral route once daily
- 1 tablet (80 mg) by oral route once daily
- 2 tablets (140 mg) by oral route once daily
- 1 tablet (140 mg) by oral route once daily
Myeloid blast phase philadelphia chromosome (+) CML
- 2 tablets (40 mg) by oral route once daily
- 1 tablet (80 mg) by oral route once daily
- 2 tablets (140 mg) by oral route once daily
- 1 tablet (140 mg) by oral route once daily
Philadelphia chromosome positive ALL
- 2 tablets (40 mg) by oral route once daily
- 1 tablet (80 mg) by oral route once daily
- 2 tablets (140 mg) by oral route once daily
- 1 tablet (140 mg) by oral route once daily
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- amiodarone
- amiodarone in dextrose,iso-osm
- artemether-lumefantrine
- BCG vaccine, live (PF)
- Coartem
- Cordarone
- disopyramide
- dronedarone
- droperidol
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- Multaq
- natalizumab
- Nexterone
- Norpace
- Norpace Cr
- Orap
- Pacerone
- pimozide
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- Acid Control (ranitidine)
- Acid Controller
- Acid Controller Complete
- Acid Reducer (cimetidine)
- Acid Reducer (famotidine)
- Acid Reducer (ranitidine)
- Acid Reducer Complete (famot)
- Acid Relief (cimetidine)
- Aciphex
- Aciphex Sprinkle
- amoxicil-clarithromy-lansopraz
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- calcium-mag-B complex-D3-hrb61
- Caprelsa
- carbamazepine
- Carbatrol
- Cerebyx
- cimetidine
- clozapine
- Clozaril
- Cold & Flu Fighter
- Complete
- deferiprone
- Deprizine
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexilant
- dexlansoprazole
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diflucan
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- Dual Action Complete
- Duexis
- enzalutamide
- Epitol
- Equetro
- esomeprazole magnesium
- esomeprazole sodium
- esomeprazole strontium
- famotidine
- famotidine (PF)
- famotidine (PF)-NaCl (iso-os)
- famotidine-Ca carb-mag hydrox
- Fareston
- Fatigue Relief Complex
- Fazaclo
- Ferriprox
- First-lansoprazole
- First-omeprazole
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosphenytoin
- Geodon
- Heartburn Prevention
- Heartburn Relief
- Heartburn Relief (famotidine)
- Heartburn Relief (ranitidine)
- Heartburn Relief 24 Hour
- Heartburn Treatment 24 Hour
- ibuprofen-famotidine
- Invega
- Invega Sustenna
- isoniazid-rifamp-pyrazinamide
- lansoprazole
- Luminal
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Mycobutin
- Mysoline
- naproxen-esomeprazole
- Nexium
- Nexium Iv
- Nexium Packet
- nilotinib
- nizatidine
- Omeclamox-pak
- omeprazole
- omeprazole magnesium
- Omeprazole+syrspend Sf Alka
- omeprazole-clarith-amoxicillin
- omeprazole-sodium bicarbonate
- paliperidone
- paliperidone palmitate
- pantoprazole
- Pepcid
- Pepcid Ac
- Pepcid Complete
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Prevacid
- Prevacid 24Hr
- Prevacid Solutab
- Prevpac
- Prilosec
- Prilosec Otc
- primidone
- propafenone
- Protonix
- Qualaquin
- quinine sulfate
- rabeprazole
- ranitidine HCl
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Rythmol
- St. John's wort
- Tagamet Hb
- Tasigna
- Tegretol
- Tegretol Xr
- tetrabenazine
- thioridazine
- toremifene
- Tums Dual Action
- vandetanib
- Versacloz
- Vimovo
- vit C-St. John wort-elder-hb30
- Wal-zan 150
- Women's Complex
- Xenazine
- Xtandi
- Zantac
- Zantac Maximum Strength
- Zegerid
- Zegerid Otc
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- Ablavar
- Acid Gone
- Acid Gone Antacid
- activated charcoal-calcium car
- Advair Diskus
- Advair Hfa
- Advanced Antacid-antigas
- Al hyd-Mg tr-alg ac-sod bicarb
- Alcalak
- alfuzosin
- Almacone
- Almacone-2
- alum-mag hydroxide-simeth
- aluminum hydrox-magnesium carb
- aluminum hydroxide gel
- aluminum-magnesium hydroxide
- amantadine HCl
- Antacid
- Antacid Anti-gas
- Antacid Anti-gas Double Str
- Antacid Calcium
- Antacid Extra Strength
- Antacid Extra-strength
- Antacid Ii Plus Simethicone
- Antacid Liquid
- Antacid M
- Antacid Maximum Strength
- Antacid Multi-symptom
- Antacid Plus Anti-gas
- Antacid Plus Extra Strength
- Antacid Regular Strength
- Antacid Supreme
- Antacid Tablet
- Antacid Ultra Strength
- Antacid With Simethicone
- Antacid-antigas
- Antacid-antigas Ii
- Antacid-simethicone
- Antacid-simethicone Ds
- Anzemet
- Apokyn
- apomorphine
- arsenic trioxide
- ASA-acetaminophen-caff-buffers
- aspirin, buffered
- aspirin-calcium carbonate
- Astagraf Xl
- azithromycin
- Bayer Plus Extra Strength
- bedaquiline
- Betapace
- Betapace Af
- Buffered Aspirin
- Bufferin
- cal phos-mag hydrx-C & D3-phos
- Cal-gest Antacid
- calcium & magnesium carbonates
- Calcium Antacid
- Calcium Antacid Tropical
- Calcium Antacid Ultra Max St
- calcium carb-mag hydrox-simeth
- calcium carbonate
- calcium carbonate-mag hydroxid
- calcium-simethicone
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Children's Pepto
- Children's Soothe
- chloroquine phosphate
- chlorpromazine
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- Comfort Gel
- Comfort Gel Extra Strength
- Complera
- Corvert
- crizotinib
- diosmin complex no.1
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- eribulin
- escitalopram oxalate
- ezogabine
- felbamate
- Felbatol
- Flanax
- flecainide
- fluticasone-salmeterol
- Foaming Antacid
- Foaming Antacid Extra Strength
- foscarnet
- Foscavir
- gadofosveset trisodium
- Gaviscon
- Gaviscon Extra Strength
- Gelusil Antacid & Anti-gas
- Geri-lanta
- Geri-mox Antacid-antigas
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Heartburn Antacid
- Hecoria
- ibutilide fumarate
- indapamide
- isradipine
- Istodax
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- Lexapro
- Liquid Antacid
- lithium carbonate
- lithium citrate
- Lithobid
- Maalox Advanced
- Maalox Maximum Strength
- Mag-al
- Mag-al Plus
- Mag-al Plus Extra Strength
- magaldrate
- magaldrate-simethicone
- Maglox
- magnesium hydroxide
- magnesium-aluminum-alginic ac
- Masanti Double Strength
- methadone
- Methadone Intensol
- Methadose
- Mi-acid
- Milk Of Magnesia
- Milk Of Magnesia Concentrated
- Mintox
- Mintox Maximum Strength
- Mintox Plus
- moexipril
- moexipril-hydrochlorothiazide
- Nebupent
- Nexavar
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- norfloxacin
- Noroxin
- Ob Complete One
- octreotide acetate
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- pasireotide
- pazopanib
- Pedia-lax
- Pentam
- pentamidine
- Phillips Milk Of Magnesia
- PN85-iron cb&asp g-FA-dha-fish
- Potiga
- Pro-cal
- procainamide
- Prograf
- quetiapine
- Ri-gel
- Ri-gel Ii
- Ri-mag
- Ri-mag Plus
- Ri-mox
- Ri-mox Plus
- Riginic
- rilpivirine
- romidepsin
- Rulox
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Signifor
- Sirturo
- Smooth Antacid
- Soltamox
- sorafenib
- Sorine
- sotalol
- Sotalol Af
- sunitinib
- Supreme Antacid
- Sutent
- tacrolimus
- tamoxifen
- telavancin
- Tikosyn
- tizanidine
- Toxin Control
- Tri-buffered Aspirin
- Trisenox
- Tums
- Tums E-x
- Tums Extra Strength Smoothies
- Tums Freshers
- Tums Ultra
- Tykerb
- Ultra Strength Antacid
- Ultra Strength Calcium Antacid
- Uniretic
- Univasc
- Uroxatral
- Vanquish
- vardenafil
- Vasculera
- vemurafenib
- venlafaxine
- Vibativ
- Votrient
- Women's Aspirin With Calcium
- Xalkori
- Zanaflex
- Zelboraf
- Zithromax
- Zithromax Tri-pak
- Zithromax Z-pak
- Zmax
- Zofran
- Zofran Odt
- Zuplenz
- Congenital long QT syndrome
- Lactating mother
- Pulmonary arterial hypertension
- Torsades de pointes
Contraindicated
- Acute decompensated heart failure
- Ascites
- Gastrointestinal hemorrhage
- Hemorrhage
- Intracerebral hemorrhage
- Pericardial effusion
- Pleural effusions
- Pregnancy
- Prolonged QT interval
- Severe anemia
- Severe neutropenic disorder
- Severe thrombocytopenia
Severe
Moderate
- Acute myocardial infarction
- Cardiopulmonary impairment
- Edema
- Reactivation of hepatitis B
SPRYCEL (DASATINIB)
- Accelerated phase philadelphia chromosome (+) CML
- Chronic phase philadelphia chromosome (+) CML
- Lymphoid blast phase philadelphia chromosome (+) CML
- Myeloid blast phase philadelphia chromosome (+) CML
- Philadelphia chromosome positive ALL
- Anemia
- Dyspnea
- Gastrointestinal hemorrhage
- Hemorrhage
- Hypocalcemia
- Hypophosphatemia
- Infection
- Neutropenic disorder
- Pleural effusions
- Thrombocytopenic disorder
- Abdominal distension
- Abdominal pain with cramps
- Anorexia
- Arthralgias
- Body fluid retention
- Chest pain
- Chills
- Constipation
- Cough
- Diarrhea
- Dizziness
- Edema
- Fatigue
- Fever
- General weakness
- Malaise
- Musculoskeletal pain
- Nausea
- Pain
- Peripheral neuropathy
- Pruritus of skin
- Skin rash
- Stomatitis
- Upper respiratory infection
- Vomiting
- Weight gain
- Weight loss
More Frequent
Severe
Less Severe
- Acute confusion
- Acute myocardial infarction
- Asthma
- Bacterial sepsis
- Cardiac arrhythmia
- Cardiomegaly
- Chemotherapy-induced hyperuricemia
- Colitis
- Enterocolitis
- Heart failure
- Herpes simplex infection
- Herpes zoster
- Hypertension
- Hypotension
- Increased creatine kinase level
- Interstitial pneumonitis
- Palpitations
- Pancytopenia
- Pericardial effusion
- Pneumonia
- Prolonged QT interval
- Pulmonary edema
- Acne vulgaris
- Alopecia
- Bruising
- Conjunctivitis
- Depression
- Drowsy
- Dry eye
- Dry skin
- Dysgeusia
- Dyspepsia
- Dysphagia
- Flushing
- Gastritis
- Gynecomastia
- Hyperhidrosis
- Increased urinary frequency
- Insomnia
- Mood changes
- Muscle rigidity
- Muscle weakness
- Myalgias
- Skin inflammation
- Skin photosensitivity
- Syncope
- Tinnitus
- Tremor
- Urticaria
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute coronary syndrome
- Acute hepatic failure
- Acute respiratory distress syndrome
- Angina
- Ascites
- Atrial fibrillation
- Atrial flutter
- Bullous dermatitis
- Cholestasis
- Erythema multiforme
- Esophagitis
- Hepatitis
- Intracerebral hemorrhage
- Myocardial ischemia
- Nephrotic syndrome
- Palmar-plantar erythrodysesthesia
- Pancreatitis
- Posterior reversible encephalopathy syndrome
- Pulmonary arterial hypertension
- Pulmonary hypertension
- Pulmonary thromboembolism
- Pure red cell aplasia
- Reactivation of hepatitis B
- Renal failure
- Rhabdomyolysis
- Seizure disorder
- Stevens-johnson syndrome
- Thromboembolic disorder
- Thrombotic thrombocytopenic purpura
- Transient cerebral ischemia
- Ventricular tachycardia
Less Severe
- Headache disorder
- Nail disorders
- Optic neuritis
- Voice change
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Dasatinib
Monitor bone growth and development. Risk of epiphyseal delayed fusion, osteopenia, growth retardation, and gynecomastia.
- 1 Day – 18 Years
- Monitor bone growth and development. Risk of epiphyseal delayed fusion, osteopenia, growth retardation, and gynecomastia.
Dasatinib
- Severity Level:
D
- Additional Notes: Case reports of hydrops fetalis & fetal bicytopenia; teratogenic in animals
Contraindicated
Dasatinib
Insufficient data available; potential for serious side effects
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insufficient data available; potential for serious side effects |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Dasatinib
Cardiovascular-Elderly are more likely to experience acute heart failure adverse outcomes. Pulmonary-With new onset dyspnea, consider pulmonary edema, pleural effusion, pulmonary arterial hypertension (PAH). Use caution with pre-existing cardiopulmonary disease. Gastrointestinal-Elderly are more likely to experience gastrointestinal bleeding adverse events. Hepatic-Use caution in hepatic impairment associated with aging.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | Y | N | Y | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Accelerated phase philadelphia chromosome (+) CML | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| Chronic phase philadelphia chromosome (+) CML | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| Lymphoid blast phase philadelphia chromosome (+) CML | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| Myeloid blast phase philadelphia chromosome (+) CML | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| Philadelphia chromosome positive ALL | |
| C91.0 | Acute lymphoblastic leukemia [ALl] |
| C91.00 | Acute lymphoblastic leukemia not having achieved remission |
| C91.02 | Acute lymphoblastic leukemia, in relapse |
| 0-9 | A-Z |
|---|---|
| C91.0 | Acute lymphoblastic leukemia [ALl] |
| C91.00 | Acute lymphoblastic leukemia not having achieved remission |
| C91.02 | Acute lymphoblastic leukemia, in relapse |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
Formulary Reference Tool