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AUGTYRO (repotrectinib)
- ROS1 positive non-small cell lung cancer
40 mg capsule
- 4 capsules (160 mg) by oral route 2 times per day
Default screening record
- 2 capsules (80 mg) by oral route 2 times per day
- 2 capsules (80 mg) by oral route once daily for 14 days
- 3 capsules (120 mg) by oral route once daily for 14 days
- 3 capsules (120 mg) by oral route 2 times per day
- 4 capsules (160 mg) by oral route once daily for 14 days
- 4 capsules (160 mg) by oral route 2 times per day
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- axitinib
- bedaquiline
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- guanfacine
- Inlyta
- Intuniv Er
- Olysio
- simeprevir
- Sirturo
- Tenex
- Versacloz
Severe
Moderate
- None
- Lactation
Contraindicated
- Abnormal hepatic function tests
- Hyperbilirubinemia
- Hyperuricemia
- Interstitial lung disease
- Myopathy with CK elevation
- Pregnancy
Severe
Moderate
- None
AUGTYRO (repotrectinib)
- ROS1 positive non-small cell lung cancer
- None
- Abnormal hepatic function tests
- Acute cognitive impairment
- Anemia
- Ataxia
- Constipation
- Cough
- Diarrhea
- Disturbance of attention
- Dizziness
- Dysgeusia
- Dyspnea
- Edema
- Fatigue
- Headache disorder
- Lymphopenia
- Memory impairment
- Muscle weakness
- Myalgia
- Nausea
- Neutropenic disorder
- Peripheral neuropathy
- Prolonged activated partial thromboplastin time
- Visual changes
- Vomiting
- Weight gain
More Frequent
Severe
Less Severe
- Fracture
- Interstitial pneumonitis
- Depression
- Drowsy
- Gamma-glutamyl transferase raised
- Hyperglycemia
- Hypermagnesemia
- Hyperuricemia
- Hyponatremia
- Hypophosphatemia
- Increased alkaline phosphatase
- Increased creatine kinase level
- Insomnia
- Irritability
- Leukopenia
- Symptoms of anxiety
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Interstitial lung disease
Less Severe
- Hyperbilirubinemia
- Hypersomnia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Repotrectinib
Safety and efficacy not established in pediatrics.
- 1 Day – 18 Years
- Safety and efficacy not established in pediatrics.
Repotrectinib
- Severity Level:
D
- Additional Notes: Based on drug pharmacology, developmental toxicity is possible
Contraindicated
Repotrectinib
Avoid breastfeeding during treatment and for 10 days after last dose
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Avoid breastfeeding during treatment and for 10 days after last dose |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| ROs1 positive non-small cell lung cancer | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
| 0-9 | A-Z |
|---|---|
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
Formulary Reference Tool