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LYSODREN (MITOTANE)
- Adrenal cortex carcinoma
500 mg tablet
- Dosage information is not available
- Adalat Cc
- Afeditab Cr
- artemether-lumefantrine
- boceprevir
- Coartem
- Complera
- Edurant
- emtricitab-rilpivirine-tenofov
- Incivek
- Latuda
- lurasidone
- natalizumab
- Nifedical Xl
- nifedipine
- Procardia
- Procardia Xl
- rilpivirine
- telaprevir
- Tysabri
- Vfend
- Vfend Iv
- Victrelis
- voriconazole
Contraindicated
- Afinitor
- Afinitor Disperz
- Aldactazide
- Aldactone
- aprepitant
- Astagraf Xl
- axitinib
- bedaquiline
- bortezomib
- Bosulif
- bosutinib
- Brilinta
- cabozantinib
- Caprelsa
- Cometriq
- crizotinib
- cyclosporine
- cyclosporine modified
- dabrafenib
- dasatinib
- dextromethorphan-quinidine
- elvitegr-cobicist-emtric-tenof
- Emend
- enzalutamide
- erlotinib
- everolimus
- Fareston
- fosaprepitant
- Gengraf
- Gleevec
- guanfacine
- Hecoria
- ibrutinib
- imatinib
- Imbruvica
- Inlyta
- Intuniv Er
- Istodax
- ivacaftor
- Jentadueto
- Kalydeco
- lapatinib
- linagliptin
- linagliptin-metformin
- mefloquine
- Neoral
- Nexavar
- nilotinib
- Nuedexta
- Olysio
- pazopanib
- pomalidomide
- Pomalyst
- Prograf
- Qualaquin
- quetiapine
- quinidine gluconate
- quinidine sulfate
- quinine sulfate
- Rapamune
- romidepsin
- Samsca
- Sandimmune
- Seroquel Xr
- simeprevir
- sirolimus
- Sirturo
- Soltamox
- sorafenib
- spironolacton-hydrochlorothiaz
- spironolactone
- Sprycel
- Stribild
- sunitinib
- Sutent
- tacrolimus
- Tafinlar
- tamoxifen
- Tarceva
- Tasigna
- temsirolimus
- Tenex
- ticagrelor
- tolvaptan
- toremifene
- Torisel
- Tradjenta
- Tykerb
- vandetanib
- Velcade
- Votrient
- Xalkori
- Xtandi
- Zortress
Severe
Moderate
- Abilify
- Abilify Discmelt
- Abilify Maintena
- Adoxa
- alprazolam
- Alprazolam Intensol
- aripiprazole
- Aromasin
- Astramorph-pf
- Ativan
- Avidoxy
- Avinza
- bosentan
- Buprenex
- buprenorphine
- buprenorphine-naloxone
- Butrans
- Daliresp
- Depodur (pf)
- Diastat
- Diastat Acudial
- diazepam
- Diazepam Intensol
- Diskets
- Dolophine
- Doryx
- Doxy-100
- doxycycline calcium
- doxycycline hyclate
- doxycycline monohydrate
- Duramorph (pf)
- exemestane
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Iclusig
- Kadian
- lorazepam
- Lorazepam Intensol
- macitentan
- methadone
- Methadone Intensol
- Methadose
- midazolam
- midazolam (PF)
- Monodox
- Morgidox
- morphine
- morphine (PF)
- morphine concentrate
- morphine liposomal (PF)
- Ms Contin
- Niravam
- Opsumit
- Oracea
- ponatinib
- regorafenib
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- roflumilast
- Seroquel
- Stivarga
- Suboxone
- Tracleer
- triazolam
- Valium
- Vibramycin
- Xanax
- Xanax Xr
- Zubsolv
- Lactating mother
Contraindicated
- Adrenal cortical insufficiency
- Disease of liver
- Major traumatic injury
- Pregnancy
- Shock
Severe
Moderate
- None
LYSODREN (MITOTANE)
- Adrenal cortex carcinoma
- Acute adrenocortical insufficiency
- Anorexia
- Depression
- Diarrhea
- Dizziness
- Nausea
- Skin rash
- Vertigo
- Vomiting
More Frequent
Severe
Less Severe
- Cataracts
- Diplopia
- Hemorrhagic cystitis
- Retinal disorder
- Blurred vision
- Drowsy
- Fever
- Flushing
- Hypertension
- Lethargy
- Myalgias
- Orthostatic hypotension
- Sedation
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- CNS toxicity
- Hepatitis
- Hypothyroidism
- Neutropenic disorder
- Ovarian cyst
Less Severe
- Acute confusion
- Altered mental status
- Ataxia
- Dysarthria
- General weakness
- Gynecomastia
- Headache disorder
- Hematuria
- Hypercholesterolemia
- Hypertriglyceridemia
- Proteinuria
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Mitotane
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Mitotane
- Severity Level:
D
- Additional Notes: Human data indicates fetal risk; preterm birth and early pregnancy loss reported
Contraindicated
Mitotane
Long half life, potential for infant toxicity
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Long half life, potential for infant toxicity |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Mitotane can make it more difficult for your body to respond to physical stress. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication. Your doctor may need to stop this medication and prescribe another medication (corticosteroid) during this time.
| Adrenal cortex carcinoma | |
| C74.0 | Malignant neoplasm of cortex of adrenal gland |
| C74.00 | Malignant neoplasm of cortex of unspecified adrenal gland |
| C74.01 | Malignant neoplasm of cortex of right adrenal gland |
| C74.02 | Malignant neoplasm of cortex of left adrenal gland |
| 0-9 | A-Z |
|---|---|
| C74.0 | Malignant neoplasm of cortex of adrenal gland |
| C74.00 | Malignant neoplasm of cortex of unspecified adrenal gland |
| C74.01 | Malignant neoplasm of cortex of right adrenal gland |
| C74.02 | Malignant neoplasm of cortex of left adrenal gland |
Formulary Reference Tool