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DROXIA (HYDROXYUREA)
- Sickle cell disease
- Sickle cell disease with crisis
200 mg capsule
- 20 mg/kg by oral route once daily
300 mg capsule
- 20 mg/kg by oral route once daily
400 mg capsule
- 20 mg/kg by oral route once daily
Sickle cell disease
- 20 mg/kg by oral route once daily
- 15 mg/kg by oral route once daily
- 25 mg/kg by oral route once daily
- 30 mg/kg by oral route once daily
- 35 mg/kg by oral route once daily
- 1 capsule (200 mg) by oral route once daily
- 1 capsule (300 mg) by oral route once daily
- 1 capsule (400 mg) by oral route once daily
Sickle cell disease with crisis
- 20 mg/kg by oral route once daily
- 15 mg/kg by oral route once daily
- 25 mg/kg by oral route once daily
- 30 mg/kg by oral route once daily
- 35 mg/kg by oral route once daily
- 1 capsule (200 mg) by oral route once daily
- 1 capsule (300 mg) by oral route once daily
- 1 capsule (400 mg) by oral route once daily
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- Actimmune
- Alferon N
- Avonex
- Avonex Administration Pack
- Betaseron
- clozapine
- Clozaril
- deferiprone
- didanosine
- Extavia
- Fazaclo
- Ferriprox
- Infergen
- interferon alfa-2b
- interferon alfa-n3
- interferon alfacon-1
- interferon beta-1a
- interferon beta-1b
- interferon gamma-1b
- Intron A
- Pegasys
- Pegasys Convenience Pack
- Pegasys Proclick
- peginterferon alfa-2a
- peginterferon alfa-2b
- Pegintron
- Pegintron Redipen
- Rebif
- Rebif Rebidose
- Rebif Titration Pack
- Sylatron
- Sylatron 4-pack
- Versacloz
- Videx 2 Gram Pediatric
- Videx 4 Gram Pediatric
- Videx Ec
Severe
Moderate
- None
- Cutaneous vasculitis
- Lactating mother
Contraindicated
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Hypoplastic anemia
- Interstitial lung disease
- Neutropenic disorder
- Pregnancy
- Thrombocytopenic disorder
Severe
Moderate
- Postirradiation erythema
DROXIA (HYDROXYUREA)
- Sickle cell disease
- Sickle cell disease with crisis
- Infection
- Leukopenia
- Neutropenic disorder
- Anorexia
- Diarrhea
- Drowsy
- Headache disorder
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Anemia
- Pulmonary infiltrates
- Thrombocytopenic disorder
- Alopecia
- Constipation
- Dry skin
- Erythema
- Pruritus of skin
- Skin rash
- Stomatitis
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Alveolitis
- Chemotherapy-induced hyperuricemia
- Cholestasis
- CNS toxicity
- Cutaneous vasculitis
- Dermatomyositis
- Hallucinations
- Hepatic failure
- Hepatitis
- Interstitial pneumonitis
- Kidney disease with reduction in GFR
- Macrocytosis
- Maculopapular rash
- Malignant neoplasm of skin
- Pancreatitis
- Pulmonary fibrosis
- Radiation recall syndrome
- Secondary acute myeloid leukemia
- Seizure disorder
- Skin ulcer
- Systemic lupus erythematosus
- Tonic clonic seizure
- Uric acid nephropathy
Less Severe
- Acute confusion
- Azoospermia
- Chills
- Dizziness
- Dyspnea
- Dysuria
- Edema
- Fever
- Gastritis
- General weakness
- Malaise
- Nail disorders
- Oligospermia
- Skin atrophy
- Skin pigmentation enhancement
- Skin scaling
- Weight gain
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Hydroxyurea
Limited data available. Safety and efficacy not established.
Increased risk of neutropenia. Monitor growth rate.
- 1 Day – 364 Days
- Limited data available. Safety and efficacy not established.
- Increased risk of neutropenia. Monitor growth rate.
- 1 Years – 17 Years
- Limited data available. Safety and efficacy not established.
- Increased risk of neutropenia. Monitor growth rate.
Hydroxyurea
- Severity Level:
D
- Additional Notes: Insuff human data; based on pharmacology dev tox possible
Contraindicated
Hydroxyurea
Potential for serious adverse effects based on drug pharmacology
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Potential for serious adverse effects based on drug pharmacology |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Hydroxyurea
General-Increased sensitivity to effects and may require lower dose regimen. Renal-May need to reduce the dose for CrCL< 60 mL/min.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- This medication decreases bone marrow function, an effect that may lead to a low number of blood cells such as red cells, white cells, and platelets. This effect can cause anemia, decrease your body's ability to fight an infection, or cause easy bruising/bleeding. Tell your doctor right away if you develop any of the following symptoms: signs of infection (such as sore throat that doesn't go away, fever, chills), easy bruising/bleeding, pale skin, unusual tiredness.<br /><br /> Hydroxyurea may cause other cancers (such as secondary leukemia, skin cancer). Protect your skin from the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps.<br /><br />Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you notice any symptoms of cancer, such as swollen glands, sudden weight loss, night sweats, or unusual skin growths/moles.
| Sickle cell disease | |
| D57 | Sickle-cell disorders |
| D57.0 | Hb-SS disease with crisis |
| D57.00 | Hb-SS disease with crisis, unspecified |
| D57.01 | Hb-SS disease with acute chest syndrome |
| D57.02 | Hb-SS disease with splenic sequestration |
| D57.1 | Sickle-cell disease without crisis |
| D57.2 | Sickle-cell/hb-C disease |
| D57.20 | Sickle-cell/hb-C disease without crisis |
| D57.21 | Sickle-cell/hb-C disease with crisis |
| D57.211 | Sickle-cell/hb-C disease with acute chest syndrome |
| D57.212 | Sickle-cell/hb-C disease with splenic sequestration |
| D57.219 | Sickle-cell/hb-C disease with crisis, unspecified |
| D57.4 | Sickle-cell thalassemia |
| D57.40 | Sickle-cell thalassemia without crisis |
| D57.41 | Sickle-cell thalassemia with crisis |
| D57.411 | Sickle-cell thalassemia with acute chest syndrome |
| D57.412 | Sickle-cell thalassemia with splenic sequestration |
| D57.419 | Sickle-cell thalassemia with crisis, unspecified |
| D57.8 | Other sickle-cell disorders |
| D57.80 | Other sickle-cell disorders without crisis |
| D57.81 | Other sickle-cell disorders with crisis |
| D57.811 | Other sickle-cell disorders with acute chest syndrome |
| D57.812 | Other sickle-cell disorders with splenic sequestration |
| D57.819 | Other sickle-cell disorders with crisis, unspecified |
| Sickle cell disease with crisis | |
| D57.0 | Hb-SS disease with crisis |
| D57.00 | Hb-SS disease with crisis, unspecified |
| D57.01 | Hb-SS disease with acute chest syndrome |
| D57.02 | Hb-SS disease with splenic sequestration |
| D57.21 | Sickle-cell/hb-C disease with crisis |
| D57.211 | Sickle-cell/hb-C disease with acute chest syndrome |
| D57.212 | Sickle-cell/hb-C disease with splenic sequestration |
| D57.219 | Sickle-cell/hb-C disease with crisis, unspecified |
| D57.41 | Sickle-cell thalassemia with crisis |
| D57.411 | Sickle-cell thalassemia with acute chest syndrome |
| D57.412 | Sickle-cell thalassemia with splenic sequestration |
| D57.419 | Sickle-cell thalassemia with crisis, unspecified |
| D57.81 | Other sickle-cell disorders with crisis |
| D57.811 | Other sickle-cell disorders with acute chest syndrome |
| D57.812 | Other sickle-cell disorders with splenic sequestration |
| D57.819 | Other sickle-cell disorders with crisis, unspecified |
| 0-9 | A-Z |
|---|---|
| D57 | Sickle-cell disorders |
| D57.0 | Hb-SS disease with crisis |
| D57.0 | Hb-SS disease with crisis |
| D57.00 | Hb-SS disease with crisis, unspecified |
| D57.00 | Hb-SS disease with crisis, unspecified |
| D57.01 | Hb-SS disease with acute chest syndrome |
| D57.01 | Hb-SS disease with acute chest syndrome |
| D57.02 | Hb-SS disease with splenic sequestration |
| D57.02 | Hb-SS disease with splenic sequestration |
| D57.1 | Sickle-cell disease without crisis |
| D57.2 | Sickle-cell/hb-C disease |
| D57.20 | Sickle-cell/hb-C disease without crisis |
| D57.21 | Sickle-cell/hb-C disease with crisis |
| D57.21 | Sickle-cell/hb-C disease with crisis |
| D57.211 | Sickle-cell/hb-C disease with acute chest syndrome |
| D57.211 | Sickle-cell/hb-C disease with acute chest syndrome |
| D57.212 | Sickle-cell/hb-C disease with splenic sequestration |
| D57.212 | Sickle-cell/hb-C disease with splenic sequestration |
| D57.219 | Sickle-cell/hb-C disease with crisis, unspecified |
| D57.219 | Sickle-cell/hb-C disease with crisis, unspecified |
| D57.4 | Sickle-cell thalassemia |
| D57.40 | Sickle-cell thalassemia without crisis |
| D57.41 | Sickle-cell thalassemia with crisis |
| D57.41 | Sickle-cell thalassemia with crisis |
| D57.411 | Sickle-cell thalassemia with acute chest syndrome |
| D57.411 | Sickle-cell thalassemia with acute chest syndrome |
| D57.412 | Sickle-cell thalassemia with splenic sequestration |
| D57.412 | Sickle-cell thalassemia with splenic sequestration |
| D57.419 | Sickle-cell thalassemia with crisis, unspecified |
| D57.419 | Sickle-cell thalassemia with crisis, unspecified |
| D57.8 | Other sickle-cell disorders |
| D57.80 | Other sickle-cell disorders without crisis |
| D57.81 | Other sickle-cell disorders with crisis |
| D57.81 | Other sickle-cell disorders with crisis |
| D57.811 | Other sickle-cell disorders with acute chest syndrome |
| D57.811 | Other sickle-cell disorders with acute chest syndrome |
| D57.812 | Other sickle-cell disorders with splenic sequestration |
| D57.812 | Other sickle-cell disorders with splenic sequestration |
| D57.819 | Other sickle-cell disorders with crisis, unspecified |
| D57.819 | Other sickle-cell disorders with crisis, unspecified |
Formulary Reference Tool