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NEXAVAR (SORAFENIB TOSYLATE)
- Differentiated thyroid carcinoma
- Liver cell carcinoma
- Renal cell carcinoma
200 mg tablet
- 2 tablets (400 mg) by oral route 2 times per day
Differentiated thyroid carcinoma
- 1 tablet (200 mg) by oral route once daily
- 1 tablet (200 mg) by oral route 2 times per day
- 2 tablets (400 mg) by oral route 2 times per day
Liver cell carcinoma
- 1 tablet (200 mg) by oral route once daily
- 2 tablets (400 mg) by oral route 2 times per day
- 2 tablets (400 mg) by oral route every other day
- 2 tablets (400 mg) by oral route once daily
Renal cell carcinoma
- 1 tablet (200 mg) by oral route once daily
- 2 tablets (400 mg) by oral route 2 times per day
- 2 tablets (400 mg) by oral route every other day
- 2 tablets (400 mg) by oral route once daily
- zoster vaccine live (PF)
- Zostavax (pf)
- Yf-vax (pf)
- yellow fever vaccine live (PF)
- Vivotif Berna Vaccine
- Varivax (pf)
- varicella virus vacc live (PF)
- typhoid vaccine
- rotavirus vaccine live, penta
- Rotateq Vaccine
- Proquad (pf)
- adenovirus vaccine live type-7
- adenovirus vaccine live type-4
- adenovirus vac live type-4 & 7
- measles,mumps,rub,varicel(PF)
- measles,mumps&rubella vacc(PF)
- M-m-r Ii (pf)
- Flumist 2013-2014
- flu vac,qval 2013-14 (2-49yrs)
- BCG vaccine, live (PF)
Contraindicated
- ziprasidone mesylate
- ziprasidone HCl
- Xtandi
- Women's Complex
- vit C-St. John wort-elder-hb30
- Versacloz
- Tegretol Xr
- Tegretol
- St. John's wort
- Rifater
- rifampin-isoniazid
- rifampin
- Rifamate
- Rifadin
- rifabutin
- primidone
- pimozide
- phenytoin sodium extended
- phenytoin sodium
- phenytoin
- Phenytek
- phenobarbital sodium
- phenobarbital
- phenobarb-hyoscy-atropine-scop
- Pacerone
- Orap
- Norpace Cr
- Norpace
- Nexterone
- Mysoline
- Mycobutin
- Multaq
- Luminal
- isoniazid-rifamp-pyrazinamide
- Geodon
- fosphenytoin
- Ferriprox
- Fazaclo
- Fatigue Relief Complex
- Equetro
- Epitol
- enzalutamide
- droperidol
- dronedarone
- Donnatal
- disopyramide
- Dilantin-125
- Dilantin Kapseal
- Dilantin Infatabs
- Dilantin Extended
- Dilantin
- Dexpak 6 Day
- Dexpak 13 Day
- Dexpak 10 Day
- dexamethasone sodium phosphate
- dexamethasone sodium phos (PF)
- Dexamethasone Intensol
- dexamethasone
- deferiprone
- Cordarone
- Cold & Flu Fighter
- Coartem
- Clozaril
- clozapine
- Cerebyx
- Carbatrol
- carbamazepine
- calcium-mag-B complex-D3-hrb61
- Belladonna-phenobarbital
- B cplx-C-St.Johnwrt-K.&S.ginsg
- artemether-lumefantrine
- amiodarone in dextrose,iso-osm
- amiodarone
Severe
Moderate
- Zuplenz
- Zofran Odt
- Zofran
- Zmax
- Zithromax Z-pak
- Zithromax Tri-pak
- Zithromax
- Zelboraf
- Zanaflex
- Xenazine
- Xalkori
- warfarin
- Votrient
- voriconazole
- Vibativ
- Vfend Iv
- Vfend
- venlafaxine
- vemurafenib
- vardenafil
- vandetanib
- Uroxatral
- Univasc
- Uniretic
- Tykerb
- Trisenox
- toremifene
- tizanidine
- Tikosyn
- thioridazine
- tetrabenazine
- telavancin
- Taxotere
- Tasigna
- tamoxifen
- tacrolimus
- Symbicort
- Sutent
- sunitinib
- Sprycel
- Sotalol Af
- sotalol
- Sorine
- Soltamox
- Sirturo
- Signifor
- Seroquel Xr
- Seroquel
- Serevent Diskus
- saquinavir mesylate
- Sandostatin Lar Depot
- Sandostatin
- Sancuso
- salmeterol
- Rythmol
- romidepsin
- risperidone microspheres
- risperidone
- Risperdal M-tab
- Risperdal Consta
- Risperdal
- rilpivirine
- quinine sulfate
- quetiapine
- Qualaquin
- propafenone
- Prograf
- procainamide
- Potiga
- posaconazole
- Perforomist
- pentamidine
- Pentam
- pazopanib
- pasireotide
- palonosetron
- paliperidone palmitate
- paliperidone
- ondansetron HCl (PF)
- ondansetron HCl
- ondansetron
- ofloxacin
- octreotide acetate
- Noxafil
- Noroxin
- norfloxacin
- nilotinib
- nicardipine in NaCl (iso-os)
- nicardipine in dextrose,iso-os
- nicardipine
- Nebupent
- moxifloxacin in NaCl (iso-osm)
- Advair Hfa
- Advair Diskus
- Ablavar
- moxifloxacin
- mometasone-formoterol
- moexipril-hydrochlorothiazide
- moexipril
- Methadose
- Methadone Intensol
- methadone
- lopinavir-ritonavir
- Lithobid
- lithium citrate
- lithium carbonate
- levofloxacin in D5W
- levofloxacin
- Levitra
- Levaquin In 5 % Dextrose
- Levaquin
- lapatinib
- Kaletra
- Jantoven
- Istodax
- isradipine
- Invirase
- Invega Sustenna
- Invega
- indapamide
- ibutilide fumarate
- Hecoria
- haloperidol lactate
- haloperidol decanoate
- haloperidol
- Haldol Decanoate
- Haldol
- Halaven
- Granisol
- granisetron (PF)
- granisetron
- gadoxetate
- gadofosveset trisodium
- Foscavir
- foscarnet
- formoterol fumarate
- Foradil Aerolizer
- fluticasone-salmeterol
- flecainide
- Felbatol
- felbamate
- Fareston
- ezogabine
- eribulin
- Eovist
- emtricitab-rilpivirine-tenofov
- Effexor Xr
- Edurant
- Dulera
- Dolophine
- dolasetron
- dofetilide
- docetaxel
- Docefrez
- Diskets
- dasatinib
- crizotinib
- Coumadin
- Corvert
- Complera
- citalopram
- ciprofloxacin in D5W
- ciprofloxacin (mixture)
- ciprofloxacin
- Cipro Xr
- Cipro In D5W
- Cipro
- chlorpromazine
- chloroquine phosphate
- Celexa
- Cardene Sr
- Cardene Iv In Sodium Chloride
- Cardene Iv In Dextrose
- Cardene Iv
- Caprelsa
- budesonide-formoterol
- Betapace Af
- Betapace
- bedaquiline
- azithromycin
- Avelox In Nacl (iso-osmotic)
- Avelox Abc Pack
- Avelox
- Astagraf Xl
- arsenic trioxide
- apomorphine
- Apokyn
- Anzemet
- amantadine HCl
- Aloxi
- alfuzosin
- Acute pancreatitis
- Arterial aneurysm
- Arterial dissection
- Congenital long QT syndrome
- Gastrointestinal perforation
- Lactating mother
- Prolonged QT interval
Contraindicated
- Abnormal hepatic function tests
- Acute myocardial infarction
- Angina
- Aseptic necrosis of jaw bone
- Drug-induced hepatitis
- Hemorrhage
- Hypokalemia
- Hypomagnesemia
- Invasive surgical procedure
- Myocardial ischemia
- Pregnancy
- Severe neutropenic disorder
- Severe thrombocytopenia
- Unstable angina pectoris
Severe
Moderate
- Anemia
- Bradycardia
- Chronic heart failure
- Depression
- Hypertension
- Hypocalcemia
- Hypophosphatemia
- Impaired wound healing
- Increased risk of bleeding
- Increased risk of bleeding due to coagulation disorder
NEXAVAR (SORAFENIB TOSYLATE)
- Differentiated thyroid carcinoma
- Liver cell carcinoma
- Renal cell carcinoma
- Anemia
- Depression
- Exfoliative dermatitis
- Gastrointestinal hemorrhage
- Hemorrhage
- Hypertension
- Hypophosphatemia
- Leukopenia
- Lymphopenia
- Neutropenic disorder
- Respiratory tract hemorrhage
- Thrombocytopenic disorder
- Acne vulgaris
- Acute abdominal pain
- Alopecia
- Anorexia
- Arthralgias
- Bone pain
- Constipation
- Diarrhea
- Dry skin
- Dyspepsia
- Dyspnea
- Eczema
- Elevated serum lipase
- Erectile dysfunction
- Erythema
- Fatigue
- Fever
- Flu-like symptoms
- Flushing
- General weakness
- Headache disorder
- Hoarseness
- Hypocalcemia
- Myalgias
- Nausea
- Palmar-plantar erythrodysesthesia
- Peripheral neuropathy
- Pruritus of skin
- Skin rash
- Stomatitis
- Vomiting
- Weight loss
More Frequent
Severe
Less Severe
- Acute myocardial infarction
- Chronic heart failure
- Hypothyroidism
- Myocardial ischemia
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute pancreatitis
- Anaphylaxis
- Angioedema
- Aseptic necrosis of jaw bone
- Cardiac arrhythmia
- Cholecystitis
- Dehydration
- Drug-induced hepatitis
- Erythema multiforme
- Gastrointestinal perforation
- Hepatic failure
- Hyperbilirubinemia
- Hypersensitivity drug reaction
- Hypertensive crisis
- Hypokalemia
- Hyponatremia
- Infection
- Interstitial lung disease
- Intracerebral hemorrhage
- Keratoacanthoma
- Nephrotic syndrome
- Posterior reversible encephalopathy syndrome
- Prolonged QT interval
- Renal failure
- Rhabdomyolysis
- Stevens-johnson syndrome
- Thromboembolic disorder
- Toxic epidermal necrolysis
- Transient cerebral ischemia
Less Severe
- Dysphagia
- Folliculitis
- Gastritis
- Gastroesophageal reflux disease
- Gynecomastia
- Hyperthyroidism
- Pain
- Proteinuria
- Rhinorrhea
- Tinnitus
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Sorafenib
Not studied in pediatrics. No safety and efficacy. Potential risk of bone and bone marrow abnormalities.
- 1 Day – 18 Years
- Not studied in pediatrics. No safety and efficacy. Potential risk of bone and bone marrow abnormalities.
Sorafenib
- Severity Level:
D
- Additional Notes: Use contraception during treatment and for 6 months after; may cause fetal harm
Contraindicated
Sorafenib
Insufficient human data avail; potential for serious adverse effects
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insufficient human data avail; potential for serious adverse effects |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
Differentiated thyroid carcinoma | |
C73 | Malignant neoplasm of thyroid gland |
Liver cell carcinoma | |
C22.0 | Liver cell carcinoma |
Renal cell carcinoma | |
C64 | Malignant neoplasm of kidney, except renal pelvis |
C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
0-9 | A-Z |
---|---|
C22.0 | Liver cell carcinoma |
C64 | Malignant neoplasm of kidney, except renal pelvis |
C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
C73 | Malignant neoplasm of thyroid gland |
Formulary Reference Tool