ANGELIQ (ESTRADIOL/DROSPIRENONE)
- Atrophic vaginitis associated with menopause
- Atrophy of vulva
- Post-menopausal osteoporosis prevention
- Vasomotor symptoms associated with menopause
0.25 mg-0.5 mg tablet
- 1 tablet by oral route once daily at the same time each day swallowing whole. Do not break, crush, dissolve and/or chew.
0.5 mg-1 mg tablet
- 1 tablet by oral route once daily at the same time each day swallowing whole. Do not break, crush, dissolve and/or chew.
Atrophic vaginitis associated with menopause
- 1 tablet by oral route once daily at the same time each day swallowing whole. Do not break, crush, dissolve and/or chew.
Atrophy of vulva
- 1 tablet by oral route once daily at the same time each day swallowing whole. Do not break, crush, dissolve and/or chew.
Vasomotor symptoms associated with menopause
- 1 tablet by oral route once daily at the same time each day swallowing whole. Do not break, crush, dissolve and/or chew.
- anastrozole
- Arimidex
- Aromasin
- boceprevir
- Cyklokapron
- exemestane
- Femara
- letrozole
- Lysteda
- tranexamic acid
- Victrelis
Contraindicated
- None
Severe
Moderate
- A-hydrocort
- A-methapred
- Accupril
- Accuretic
- Aceon
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Alagesic Lq
- Aldactazide
- Aldactone
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- Alka-seltzer Gold
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Altace
- amiloride
- amiloride-hydrochlorothiazide
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- amobarbital
- Amytal
- Anaprox
- Anaprox Ds
- Ansaid
- Anucort-hc
- Anusol-hc
- Aristospan Intra-articular
- Aristospan Intralesional
- Arthrotec 50
- Ascomp With Codeine
- Atacand
- Atacand Hct
- Avalide
- Avapro
- azilsartan med-chlorthalidone
- azilsartan medoxomil
- Azor
- Belladonna-phenobarbital
- benazepril
- benazepril-hydrochlorothiazide
- Benicar
- Benicar Hct
- betamethasone acet & sod phos
- Bivigam
- Brevital
- budesonide
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- Caldolor
- Cambia
- candesartan
- candesartan-hydrochlorothiazid
- Capacet
- captopril
- captopril-hydrochlorothiazide
- Carimune Nf Nanofiltered
- Cataflam
- Celebrex
- celecoxib
- Celestone Soluspan
- Ceralyte-70
- Ceraors 75
- Cerasport
- Cerasport Ex1
- Cerebyx
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- codeine-butalbital-ASA-caff
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Colocort
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Cozaar
- Cytra K Crystals
- Cytra-3
- Cytra-k
- Daypro
- Depo-medrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Diovan Hct
- DM-GG-potassium citrate
- Donnatal
- Duexis
- Dyazide
- Dyrenium
- Ec-naprosyn
- Edarbi
- Edarbyclor
- Effer-k
- enalapril maleate
- enalapril-hydrochlorothiazide
- enalaprilat
- Entocort Ec
- Epaned
- eplerenone
- eprosartan
- eprosartan-hydrochlorothiazide
- Esgic
- ethotoin
- etodolac
- Evista
- Exforge
- Exforge Hct
- Ez Use Joint-tunnel-trigger
- Feldene
- fenoprofen
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- First-duke's
- First-mary's Mouthwash
- Flanax
- Flebogamma Dif
- Flector
- Flo-pred
- fludrocortisone
- flurbiprofen
- fosinopril
- fosinopril-hydrochlorothiazide
- fosphenytoin
- Gamastan S/d
- Gammagard Liquid
- Gammagard S-d (iga < 1 Mcg/ml)
- Gammagard S/d
- Gammaked
- Gammaplex
- Gamunex-c
- Grx Hicort 25
- Hemril-30
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- Hizentra
- hydrocodone-ibuprofen
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- Hyperlyte Cr
- Hyzaar
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- immune glob(IgG)(hum)-maltose
- immune globulin (human) (IgG)
- immune globulin(hum),capr(IgG)
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Inspra
- irbesartan
- irbesartan-hydrochlorothiazide
- Juxtapid
- K-effervescent
- K-phos No 2
- K-phos Original
- K-phos-neutral
- K-tab
- Kaochlor
- Kenalog
- ketoprofen
- ketorolac
- Klor-con
- Klor-con 10
- Klor-con M10
- Klor-con M15
- Klor-con M20
- Klor-con/ef
- lisinopril
- lisinopril-hydrochlorothiazide
- lomitapide
- losartan
- losartan-hydrochlorothiazide
- Lotensin
- Lotrel
- Luminal
- Margesic
- Marten-tab
- Mavik
- Maxzide
- Maxzide-25Mg
- Medi-lyte
- Medi-profen
- Mediproxen
- Medrol
- Medrol (pak)
- mefenamic acid
- meloxicam
- methohexital
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Micardis
- Micardis Hct
- Midol (naproxen)
- Millipred
- Millipred Dp
- Mobic
- moexipril
- moexipril-hydrochlorothiazide
- Motrin Ib
- Motrin Pm
- Mysoline
- nabumetone
- Nalfon
- Nano Vm T/f
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Nembutal Sodium
- Neoprofen (ibuprofen Lysn)(pf)
- Nutrilyte Ii
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Octagam
- olmesartan
- olmesartan-amlodipin-hcthiazid
- olmesartan-hydrochlorothiazide
- Orapred
- Orapred Odt
- oxaprozin
- Pedialyte
- Pediapred
- Pediatric Electrolyte
- pediatric multivit #18-iron-FA
- PEG 3350-bowel 2,two part prep
- Peganone
- Pennsaid
- pentobarbital sodium
- perindopril erbumine
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Phos-nak
- Phospha 250 Neutral
- Physicians Ez Use M-pred
- piroxicam
- Ponstel
- pot & sod citrate-citric acid
- potassium
- potassium & sodium phosphates
- potassium bicarb & chloride
- potassium bicarb-citric acid
- potassium chlorid-D5-0.45%NaCl
- potassium chloride
- potassium chloride in 0.9%NaCl
- potassium chloride in D5W
- potassium chloride in LR-D5
- potassium chloride-0.45 % NaCl
- potassium chloride-D5-0.2%NaCl
- potassium chloride-D5-0.3%NaCl
- potassium chloride-D5-0.9%NaCl
- potassium citrate
- potassium citrate-citric acid
- potassium Cl-calcium phos-mag
- potassium gluconate
- potassium phosphate dibasic
- potassium phosphate, monobasic
- potassium&sodium monobas phos
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- primidone
- Prinivil
- Privigen
- Proctocort
- Provil
- pseudoephedrine-ibuprofen
- quinapril
- quinapril-hydrochlorothiazide
- raloxifene
- ramipril
- Rayos
- Rectacort-hc
- Reprexain
- secobarbital sodium
- Seconal Sodium
- Sinus & Cold-d
- sod & pot chlorid-sod cit-rice
- sod phos,di & mono-K phos mono
- sodium & potassium bicarbonate
- sodium Cl-potassium chloride
- sodium-K+-mag-Ca-chlor-acetate
- sodium-potas-chloride-dextrose
- Solaraze
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Sorbutuss
- spironolacton-hydrochlorothiaz
- spironolactone
- Sprix
- Suclear
- sulindac
- Tarka
- Taron-crystals
- telmisartan
- telmisartan-amlodipine
- telmisartan-hydrochlorothiazid
- Tencon
- Teveten
- Teveten Hct
- Theralith Xr
- Thermotabs
- tolmetin
- Tpn Electrolytes
- Tpn Electrolytes Ii
- trandolapril
- trandolapril-verapamil
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- triamterene
- triamterene-hydrochlorothiazid
- Tribenzor
- Tricitrates
- Twynsta
- Uceris
- Uniretic
- Univasc
- Urocit-k 10
- Urocit-k 15
- Urocit-k 5
- valsartan-hydrochlorothiazide
- Vaseretic
- Vasotec
- Veripred 20
- Vicoprofen
- Vimovo
- vit B6-mag cit & ox-potass cit
- Voltaren-xr
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Zebutal
- Zestoretic
- Zestril
- Zipsor
- Zorvolex
- Acute myocardial infarction
- Adrenal cortical insufficiency
- Antithrombin III deficiency
- Carcinoma of breast
- Cerebrovascular accident
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Coronary artery disease
- Deep venous thrombosis
- Disease of liver
- Estrogen-dependent neoplasm
- Hyperkalemia
- Predisposition to thrombosis
- Protein C deficiency disease
- Pulmonary thromboembolism
- Retinal thrombosis
- Thromboembolic disorder
- Thrombophilia
Contraindicated
- Bed-ridden
- Coronary artery disease
- Dementia
- Diabetes mellitus
- Endometrial carcinoma
- Family history of malignant tumor of breast
- Hereditary angioedema
- Hypercalcemia
- Hyperlipidemia
- Increased cardiovascular event risk
- Invasive surgical procedure
- Kidney disease with likely reduction in GFR
- Malignant neoplasm of the ovary
- Papilledema
- Porphyria
- Retinal thrombosis
- Tobacco smoker
Severe
Moderate
- Asthma
- Depression
- Edema
- Gallbladder disease
- Hepatic porphyria
- Hypertriglyceridemia
- Hypoparathyroidism
- Hypothyroidism
- Migraine
- Seizure disorder
- Systemic lupus erythematosus
- Unspecified lump in breast
- Uterine leiomyoma
ANGELIQ (ESTRADIOL/DROSPIRENONE)
- Atrophic vaginitis associated with menopause
- Atrophy of vulva
- Post-menopausal osteoporosis prevention
- Vasomotor symptoms associated with menopause
- Abdominal distension
- Abnormal vaginal bleeding
- Irregular menstrual periods
- Abdominal distension
- Abdominal pain with cramps
- Anorexia
- Appetite changes
- Breast milk flow decreased
- Dysmenorrhea
- Edema
- Fatigue
- Gynecomastia
- Headache disorder
- Mastalgia
- Myalgias
- Nausea
- Peripheral edema
- Sinusitis
- Vaginitis
- Vulvovaginal candidiasis
- Weight gain
- Weight loss
More Frequent
Severe
Less Severe
- Endometrial hyperplasia
- Gastroenteritis
- Bronchitis
- Diarrhea
- Dizziness
- Dyspepsia
- Headache disorder
- Hypertonia
- Irritability
- Libido changes
- Migraine
- Mood changes
- Vaginal discharge
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute myocardial infarction
- Anaphylaxis
- Angioedema
- Back pain
- Carcinoma of cervix
- Cerebrovascular accident
- Change in corneal curvature
- Chest pain
- Cystitis
- Depression
- Endometrial carcinoma
- Erythema multiforme
- Erythema nodosum
- Galactorrhea not associated with childbirth
- Gallbladder obstruction
- Hepatitis
- Hyperkalemia
- Hypertension
- Hyponatremia
- Influenza
- Involuntary muscle movement
- Malignant neoplasm of the ovary
- Neoplasm of breast
- Obstructive hyperbilirubinemia
- Optic neuritis
- Pancreatitis
- Pruritus of skin
- Pulmonary thromboembolism
- Retinal thrombosis
- Skin rash
- Thromboembolic disorder
- Thrombophlebitis
- Thrombotic disorder
- Unspecified lump in breast
- Urticaria
Less Severe
- Abdominal pain with cramps
- Abnormal vaginal bleeding
- Acne vulgaris
- Alopecia
- Amenorrhea
- Back pain
- Body fluid retention
- Chest pain
- Chloasma
- Constipation
- Drowsy
- Fever
- Hirsutism
- Hyperglycemia
- Insomnia
- Mastalgia
- Menorrhagia
- Mood changes
- Nausea
- Nipple discharge
- Upper respiratory infection
- Urticaria
Contraindicated
None
Severe Precaution
Estradiol with Drospirenone
Not indicated in pediatrics.
- 1 Day – 18 Years
- Not indicated in pediatrics.
Management or Monitoring Precaution
None
Drospirenone
- Severity Level:
2
- Additional Notes: Available human data show no increased risk for major birth defects.
Estradiol
- Severity Level:
2
- Additional Notes: Not indicated during pregnancy; no known dev tox
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Drospirenone
None
Limited data indicate higher excretion may occur w/vaginal vs transderm admin
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | None |
Estradiol
None
Limited data indicate higher excretion may occur w/vaginal vs transderm admin
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data indicate higher excretion may occur w/vaginal vs transderm admin |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Estrogenic Agents (systemic)
General-Use lowest possible dose for shortest duration and in combination with a progestin as indicated to reduce the risk of endometrial hyperplasia and breast cancer. Cardiovascular-May increase risk for thromboembolic events. Avoid use in patients with known, suspected, or history of arterial or venous thromboembolic disease. Neuro/Psych-May increase the risk for dementia. Genitourinary-May aggravate urinary incontinence.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | Y | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Rarely, very serious side effects have occurred when estrogen-only and combination hormone replacement therapies (estrogen and progestin HRT) are used after menopause. Discuss the risks and benefits of hormone treatment and your personal health history with your doctor. Combination HRT should not be used to prevent heart disease or dementia.<br /><br />Combination HRT can rarely cause heart disease (e.g., heart attacks), stroke, serious blood clots (pulmonary embolism and deep venous thrombosis), dementia, and breast cancer. The risk for stroke and breast cancer increases with age, especially for women older than 75. Estrogens may also increase the risk of cancer of the ovaries.<br /><br />Some of these risks appear to depend on the length of time this drug is used and the amount of estrogen per dose. Therefore, this medication should be used for the shortest possible length of time at the lowest effective dose, so you can obtain the benefits and minimize the chance of serious side effects from long-term treatment. Discuss the details with your doctor and check with him/her regularly (e.g., every 3-6 months) to see if you still need to take this medication.<br /><br /> If you use this drug for an extended time, you should have a complete physical exam at regular intervals (e.g., once a year) or as directed by your doctor. See Notes section.
Atrophic vaginitis associated with menopause | |
N95.2 | Postmenopausal atrophic vaginitis |
Atrophy of vulva | |
N90.5 | Atrophy of vulva |
Post-menopausal osteoporosis prevention | |
Z78.0 | Asymptomatic menopausal state |
Vasomotor symptoms associated with menopause | |
N95.1 | Menopausal and female climacteric states |
N95.9 | Unspecified menopausal and perimenopausal disorder |
0-9 | A-Z |
---|---|
N90.5 | Atrophy of vulva |
N95.1 | Menopausal and female climacteric states |
N95.2 | Postmenopausal atrophic vaginitis |
N95.9 | Unspecified menopausal and perimenopausal disorder |
Z78.0 | Asymptomatic menopausal state |