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OSMITROL (MANNITOL)
- Cerebral edema
- Ocular hypertension
- Osmitrol 5 % Intravenous Solution
- Osmitrol 20 % Intravenous Solution
- Osmitrol 15 % Intravenous Solution
- Osmitrol 10 % Intravenous Solution
- Mannitol 5 % Intravenous Solution
- Mannitol 20 % Intravenous Solution
- Mannitol 10 % Intravenous Solution
- By Indication
5 % intravenous solution
- Infuse 0.25 gram/kg by intravenous route every 4 hours
20 % intravenous solution
- Infuse 0.25 gram/kg by intravenous route every 4 hours
15 % intravenous solution
- Infuse 0.25 gram/kg by intravenous route every 4 hours
10 % intravenous solution
- Infuse 0.25 gram/kg by intravenous route every 4 hours
5 % intravenous solution
- Infuse 0.25 gram/kg by intravenous route every 4 hours
20 % intravenous solution
- Infuse 0.25 gram/kg by intravenous route every 4 hours
10 % intravenous solution
- Infuse 0.25 gram/kg by intravenous route every 4 hours
Cerebral edema
- Infuse 0.25 gram/kg by intravenous route every 4 hours
- Infuse 0.25 gram/kg by intravenous route every 6 hours
- Infuse 0.5 gram/kg by intravenous route every 6 hours
- Infuse 0.5 gram/kg by intravenous route every 4 hours
- None
Contraindicated
- Curad Enema
- Disposable Enema
- Enema
- Enema Disposable
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- Oral Saline Laxative
- Osmoprep
- Phosphate Laxative
- Preparation Cleansing
- Ready-to-use Enema
- Reclast
- sod phos mono-sod phos dibasic
- sodium phosphates
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- Bethkis
- Tobi
- Tobi Podhaler
- tobramycin
- tobramycin in 0.225 % NaCl
- Anuria
- Capillary fragility
- Pulmonary congestion
- Severe chronic heart failure
- Severe dehydration
Contraindicated
- Hypernatremia
- Intracranial bleeding
- Kidney disease with reduction in GFR
Severe
Moderate
- Hyperkalemia
- Hyponatremia
- Hypovolemia
OSMITROL (MANNITOL)
- Cerebral edema
- Ocular hypertension
- None
- Headache disorder
- Nausea
- Polydipsia
- Polyuria
- Vomiting
- Xerostomia
More Frequent
Severe
Less Severe
- Urticaria
- Blurred vision
- Dizziness
- Skin rash
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acidosis
- Acute renal failure
- Allergic dermatitis
- Anaphylaxis
- Anuria
- Azotemia
- Cardiac arrest
- Chest pain
- Chills
- Chronic heart failure
- Coma
- Dysuria
- Fever
- Hematuria
- Hyperkalemia
- Hypernatremia
- Hypertension
- Hypervolemia
- Hypokalemia
- Hyponatremia
- Hypotension
- Hypovolemia
- Metabolic acidosis
- Muscle rigidity
- Pulmonary congestion
- Pulmonary edema
- Renal failure
- Seizure disorder
- Tachycardia
- Thrombophlebitis
- Urinary retention
Less Severe
- Acute confusion
- Back pain
- Cough
- Dehydration
- Dyspnea
- General weakness
- Hyperhidrosis
- Injection site sequelae
- Lethargy
- Malaise
- Myalgias
- Oliguria
- Pain
- Palpitations
- Peripheral edema
- Phlebitis after infusion
- Pruritus of skin
- Rhinitis
Contraindicated
None
Severe Precaution
Mannitol (IV)
Increased risk of electrolyte and fluid abnormality, especially in neonates. Optimal pediatric dose is unknown.
- 1 Day – 2 Years
- Increased risk of electrolyte and fluid abnormality, especially in neonates. Optimal pediatric dose is unknown.
Management or Monitoring Precaution
None
Mannitol
- Severity Level:
2
- Additional Notes: Insufficient data available
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Mannitol
None
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Mannitol
General-Risk for fluid and electrolyte imbalances. Renal-Substantially excreted by the kidney and the risk of adverse reactions to this drug may be greater in elderly patients with impaired renal function. Cardiovascular-Caution in patients with CHF, especially with renal impairment.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Cerebral edema | |
| G93.6 | Cerebral edema |
| P11.0 | Cerebral edema due to birth injury |
| Ocular hypertension | |
| H40.05 | Ocular hypertension |
| H40.051 | Ocular hypertension, right eye |
| H40.052 | Ocular hypertension, left eye |
| H40.053 | Ocular hypertension, bilateral |
| H40.059 | Ocular hypertension, unspecified eye |
| 0-9 | A-Z |
|---|---|
| G93.6 | Cerebral edema |
| H40.05 | Ocular hypertension |
| H40.051 | Ocular hypertension, right eye |
| H40.052 | Ocular hypertension, left eye |
| H40.053 | Ocular hypertension, bilateral |
| H40.059 | Ocular hypertension, unspecified eye |
| P11.0 | Cerebral edema due to birth injury |
Formulary Reference Tool