Miochol-E

Drug overview for MIOCHOL-E (acetylcholine chloride):

Generic name: acetylcholine chloride
Drug class: Parasympathetic Miotics
Therapeutic class: Ophthalmic Agents

Acetylcholine, a direct-acting parasympathomimetic agent, is a miotic.

No enhanced Uses information available for this drug.

DRUG IMAGES

MIOCHOL-E KIT

The following indications for MIOCHOL-E (acetylcholine chloride) have been approved by the FDA:

Indications:
Miosis induction during ocular surgery

Professional Synonyms:
Induce pupil constriction during ocular procedure
Induction of miosis during eye procedure

The following dosing information is available for MIOCHOL-E (acetylcholine chloride):

Dosing
Administration
Dosing Information
Generic

The usual dose of acetylcholine chloride to produce miosis during surgery is 0.5-2 mL of the 1% injection (5-20 mg) instilled into the anterior chamber before or after securing one or more sutures. To maintain miosis, 2% pilocarpine or 0.25% physostigmine solution may be applied topically immediately after surgery before application of the dressing.

Acetylcholine chloride is administered only in solution by instillation into the anterior chamber of the eye to produce miosis during ophthalmic surgery. The drug should be reconstituted immediately before use by removing the protective cap from the commercially available two-chambered vial, giving the plunger-stopper a quarter turn and pressing to force the solvent and center rubber plug into the lower chamber, and shaking the vial gently to dissolve the solid. If the rubber plug cannot be forced down or is already in the lower chamber, or if the reconstituted solution is discolored or contains a precipitate, the vial should not be used.

Reconstitution produces 2 mL of a solution containing 1% (1:100) acetylcholine chloride and 2.8% mannitol. After cleansing the plunger-stopper with 70% alcohol or other suitable germicide, the appropriate dose of acetylcholine chloride is drawn into a dry, sterile syringe with an 18- to 20-gauge needle; the needle is then replaced with a suitable atraumatic cannula for intraocular irrigation.

Instillation should be gentle and parallel to the iris face and tangential to the pupil border; flushing of the solution from the anterior chamber after miosis occurs is not necessary because of the short duration of action of the drug. In cataract surgery, acetylcholine should be used only after delivery of the lens.

No dosing information available.

No generic dosing information available.

Contraindication List
Lactation

The following adverse reaction information is available for MIOCHOL-E (acetylcholine chloride):

Overview
Severe
Less Severe

Adverse reaction overview.

No enhanced Common Adverse Effects information available for this drug.

There are 4 severe adverse reactions.

More Frequent	Less Frequent
None.	None.

Rare/Very Rare
Bradycardia Corneal nebula Dyspnea Hypotension

There are 3 less severe adverse reactions.

More Frequent	Less Frequent
None.	Corneal edema

Rare/Very Rare
Flushing Hyperhidrosis

The following precautions are available for MIOCHOL-E (acetylcholine chloride):

Pediatric
Pregnant
Lactation
Geriatric

No enhanced Pediatric Use information available for this drug.

Contraindicated

None

Severe Precaution

None

Management or Monitoring Precaution

None

No enhanced Pregnancy information available for this drug.

No enhanced Lactation information available for this drug.

No enhanced Geriatric Use information available for this drug.