LEUCOVORIN CALCIUM (LEUCOVORIN CALCIUM)
- Bone marrow suppression due to folic acid antagonism
- Methotrexate toxicity
- Pyrimethamine toxicity
- Sulfadiazine toxicity
- Trimethoprim toxicity
- Trimetrexate toxicity
10 mg tablet
- 1 tablet (10 mg) by oral route once daily
15 mg tablet
- 1 tablet (15 mg) by oral route once daily
25 mg tablet
- 1 tablet (25 mg) by oral route once daily
5 mg tablet
- 1 tablet (5 mg) by oral route once daily
10 mg tablet
- 1 tablet (10 mg) by oral route once daily
15 mg tablet
- 1 tablet (15 mg) by oral route once daily
25 mg tablet
- 1 tablet (25 mg) by oral route once daily
5 mg tablet
- 1 tablet (5 mg) by oral route once daily
Bone marrow suppression due to folic acid antagonism
- 1 tablet (5 mg) by oral route once daily
- 2 tablets (10 mg) by oral route once daily
Methotrexate toxicity
- 10 mg/m2 by oral route every 6 hours
Pyrimethamine toxicity
- 1 tablet (5 mg) by oral route once daily
- 2 tablets (10 mg) by oral route once daily
- 1 tablet (25 mg) by oral route once daily
Sulfadiazine toxicity
- 1 tablet (5 mg) by oral route every 3 days
- 2 tablets (10 mg) by oral route every 3 days
Trimethoprim toxicity
- 10 mg/m2 by oral route every 6 hours
- 1 tablet (5 mg) by oral route once daily
- 2 tablets (10 mg) by oral route once daily
Trimetrexate toxicity
- 20 mg/m2 by oral route every 6 hours
- 20 mg/m2 by oral route every 6 hours for 24 days
- None
Contraindicated
- None
Severe
Moderate
- Adrucil
- Bactrim
- Bactrim Ds
- capecitabine
- Cerebyx
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- ethotoin
- fluorouracil
- fosphenytoin
- glucarpidase
- Peganone
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- sulfamethoxazole-trimethoprim
- Sulfatrim
- Voraxaze
- Xeloda
- Pernicious anemia
- Vitamin b12 deficiency
Contraindicated
- None
Severe
Moderate
- None
LEUCOVORIN CALCIUM (LEUCOVORIN CALCIUM)
- Bone marrow suppression due to folic acid antagonism
- Methotrexate toxicity
- Pyrimethamine toxicity
- Sulfadiazine toxicity
- Trimethoprim toxicity
- Trimetrexate toxicity
- None
- None
More Frequent
Severe
Less Severe
- None
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Seizure disorder
- Urticaria
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Leucovorin
May increase possibility of seizures in children on hydantoins.
- 1 Day – 18 Years
- May increase possibility of seizures in children on hydantoins.
Leucovorin Calcium
- Severity Level:
C
- Additional Notes:
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
Leucovorin Calcium
Active metabolite of folic acid
General | Excretion Potential | Effect on Infant | Notes |
No known risks; does not adversely affect lactation | Unknown | Not known; no or inclusive data | Active metabolite of folic acid |
Contraindicated
None
Precaution Exists
Leucovorin
Elderly at increased risk of severe gastrointestinal toxicity in combination with 5-FU.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None