AUVELITY (dextromethorphan HBr/bupropion HCl)

Moderate

• A-hydrocort

• A-methapred

• Abilify

• Abilify Discmelt

• Abilify Maintena

• acarbose

• acetaminophen-codeine

• Actoplus Met

• Actoplus Met Xr

• Actos

• Adasuve

• alogliptin-metformin

• alogliptin-pioglitazone

• Amaryl

• aminophylline

• amitriptyline

• amitriptyline-chlordiazepoxide

• amoxapine

• Anafranil

• Anucort-hc

• Anusol-hc

• Apidra

• Apidra Solostar

• aripiprazole

• Aristospan Intra-articular

• Aristospan Intralesional

• Ascomp With Codeine

• betamethasone acet & sod phos

• Brisdelle

• bromphen-pseudoephed-codeine

• brompheniramine-PE-codeine

• budesonide

• Butalbital Compound W/codeine

• Butalbital Compound-codeine

• butalbital-acetaminop-caf-cod

• Capcof

• Capital With Codeine

• carisoprodol-ASA-codeine

• Celestone Soluspan

• Celexa

• Cheratussin Ac

• Cheratussin Dac

• chlorcyclizine-codeine

• chlorphen-pseudoephed-codeine

• chlorpheniramine-codeine

• chlorpheniramine-PE-codeine

• chlorpromazine

• citalopram

• clomipramine

• clozapine

• Clozaril

• clrcycliz-pseudoephed-codeine

• codeine sulfate

• codeine-butalbital-ASA-caff

• codeine-guaifenesin

• codeine-pyrilamine

• Colocort

• Compazine

• Compro

• Conzip

• Cortef

• Cortenema

• Cortifoam

• cortisone

• Cymbalta

• Depo-medrol

• desipramine

• desvenlafaxine

• desvenlafaxine fumarate

• desvenlafaxine succinate

• dexamethasone

• Dexamethasone Intensol

• dexamethasone sodium phos (PF)

• dexamethasone sodium phosphate

• dexbrompheniramine-PSE-codeine

• dexchlorphen-phenyleph-codeine

• Dexpak 10 Day

• Dexpak 13 Day

• Dexpak 6 Day

• Diabeta

• doxepin

• droperidol

• Duetact

• duloxetine

• Effexor Xr

• Elixophyllin

• Entocort Ec

• escitalopram oxalate

• Ez Use Joint-tunnel-trigger

• Fazaclo

• Fetzima

• Fioricet With Codeine

• Fiorinal-codeine #3

• First-duke's

• First-mary's Mouthwash

• Flo-pred

• fludrocortisone

• fluoxetine

• fluphenazine decanoate

• fluphenazine HCl

• fluvoxamine

• Fortamet

• Geodon

• glimepiride

• glipizide

• glipizide-metformin

• Glucophage

• Glucophage Xr

• Glucotrol

• Glucotrol Xl

• Glucovance

• Glumetza

• glyburide

• glyburide micronized

• glyburide-metformin

• Glynase

• Glyset

• Grx Hicort 25

• Guaiatussin Ac

• Guaifenesin Ac

• Guaifenesin Dac

• Guiatuss Ac

• Haldol

• Haldol Decanoate

• haloperidol

• haloperidol decanoate

• haloperidol lactate

• Hemril-30

• Humalog

• Humalog Kwikpen

• Humalog Mix 50-50

• Humalog Mix 50-50 Kwikpen

• Humalog Mix 75-25

• Humalog Mix 75-25 Kwikpen

• Humulin 70/30

• Humulin N

• Humulin N Kwikpen

• Humulin R

• Humulin R U-500 "Concentrated"

• hydrocortisone

• hydrocortisone acetate

• hydrocortisone sod succ (PF)

• hydrocortisone sod succinate

• imipramine HCl

• imipramine pamoate

• insulin asp prt-insulin aspart

• insulin aspart

• insulin detemir

• insulin glargine

• insulin glulisine

• insulin lispro

• insulin lispro protam-lispro

• insulin NPH and regular human

• insulin regular hum U-500 conc

• insulin regular human

• Invega

• Invega Sustenna

• Iophen C-nr

• Janumet

• Janumet Xr

• Jentadueto

• Kazano

• Kenalog

• Khedezla

• Kombiglyze Xr

• Lantus

• Lantus Solostar

• Latuda

• Levemir

• Levemir Flexpen

• levomilnacipran

• Lexapro

• linagliptin-metformin

• Lortuss Ex

• loxapine

• loxapine succinate

• Loxitane

• lurasidone

• Luvox Cr

• M-clear Wc

• M-end Max D

• M-end Pe

• maprotiline

• Mar-cof Bp

• Mar-cof Cg

• Medrol

• Medrol (pak)

• metformin

• methylprednisolone

• methylprednisolone acetate

• methylprednisolone sod suc(PF)

• methylprednisolone sodium succ

• methylprednisolone-bupivacaine

• miglitol

• Millipred

• Millipred Dp

• milnacipran

• mirtazapine

• nateglinide

• nefazodone

• Norpramin

• nortriptyline

• Novolin 70/30

• Novolin N

• Novolin R

• Novolog

• Novolog Flexpen

• Novolog Mix 70-30

• Novolog Mix 70-30 Flexpen

• Novolog Penfill

• NPH insulin human recomb

• nystatin-hydrocortisone-diphen

• nystatin-TCN-HC-diphenhydramin

• olanzapine

• olanzapine pamoate

• olanzapine-fluoxetine

• Oleptro Er

• Orapred

• Orapred Odt

• Oseni

• paliperidone

• paliperidone palmitate

• Pamelor

• paroxetine HCl

• paroxetine mesylate

• Paxil

• Paxil Cr

• Pediapred

• perphenazine

• perphenazine-amitriptyline

• Pexeva

• Phenadoz

• Phenergan

• Phenylhistine

• Phenylhistine Dh

• Physicians Ez Use M-pred

• pioglitazone

• pioglitazone-glimepiride

• pioglitazone-metformin

• Poly-tussin

• Poly-tussin Ac

• Poly-tussin D

• Prandimet

• Prandin

• Precose

• prednisolone

• prednisolone acetate

• prednisolone sodium phosphate

• prednisone

• Prednisone Intensol

• Pristiq

• Pro-clear Ac

• Pro-clear Caps

• Pro-red Ac (w/ Dexchlorphenir)

• prochlorperazine

• prochlorperazine Edisylate

• prochlorperazine maleate

• Proctocort

• promethazine

• Promethazine Vc

• Promethazine Vc-codeine

• promethazine-codeine

• promethazine-DM

• promethazine-phenyleph-codeine

• promethazine-phenylephrine

• Promethegan

• protriptyline

• Prozac

• Prozac Weekly

• pseudoephedrine-codeine-GG

• quetiapine

• Rayos

• Rectacort-hc

• Relcof C

• Remeron

• Remeron Soltab

• repaglinide

• repaglinide-metformin

• Riomet

• Risperdal

• Risperdal Consta

• Risperdal M-tab

• risperidone

• risperidone microspheres

• Rydex

• Sarafem

• Savella

• saxagliptin-metformin

• Seroquel

• Seroquel Xr

• sertraline

• Silenor

• sitagliptin-metformin

• Solu-cortef

• Solu-cortef (pf)

• Solu-medrol

• Solu-medrol (pf)

• Starlix

• Statuss Green (codeine)

• Surmontil

• Symbyax

• Synapryn

• tetrabenazine

• Theo-24

• Theochron

• theophylline

• theophylline in dextrose 5 %

• thioridazine

• thiothixene

• Tofranil

• Tofranil-pm

• tolazamide

• tolbutamide

• tramadol

• tramadol-acetaminophen

• tramadol-glucosamine

• trazodone

• triamcinolone acetonide

• triamcinolone hexacetonide

• triamcinolone-lidocaine

• trifluoperazine

• trimipramine

• Trymine Cg

• Tusnel C

• Tylenol-codeine #3

• Tylenol-codeine #4

• Uceris

• Ultracet

• Ultram

• Ultram Er

• venlafaxine

• Veripred 20

• Versacloz

• Viibryd

• vilazodone

• Virtussin Ac

• Vivactil

• Xenazine

• Z-tuss Ac

• Z-tuss E

• ziprasidone HCl

• ziprasidone mesylate

• Zodryl Ac 25

• Zodryl Ac 30

• Zodryl Ac 35

• Zodryl Ac 40

• Zodryl Ac 50

• Zodryl Ac 60

• Zodryl Ac 80

• Zodryl Dac 25

• Zodryl Dac 30

• Zodryl Dac 35

• Zodryl Dac 40

• Zodryl Dac 50

• Zodryl Dac 60

• Zodryl Dac 80

• Zodryl Dec 25

• Zodryl Dec 30

• Zodryl Dec 35

• Zodryl Dec 40

• Zodryl Dec 50

• Zodryl Dec 60

• Zodryl Dec 80

• Zoloft

• Zyprexa

• Zyprexa Relprevv

• Zyprexa Zydis

Moderate

• Bipolar disorder

• Hypertension

• Psychotic disorder

Bupropion

• Severity Level:

  2

• Additional Notes: Available human data suggest developmental toxicity risk is low.

Dextromethorphan

• Severity Level:

  2

• Additional Notes: Available human data show no increased risk for major birth defects

Contraindicated

None

General	Excretion Potential	Effect on Infant	Notes
			None

Precaution Exists

Bupropion

Insuff human data; low levels excreted in breastmilk;Rare seizures in infant

Insufficient data available; molecular wt low enough for possible excretion

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Excreted	Not known; no or inclusive data	Insuff human data; low levels excreted in breastmilk;Rare seizures in infant

Dextromethorphan

Insuff human data; low levels excreted in breastmilk;Rare seizures in infant

Insufficient data available; molecular wt low enough for possible excretion

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Unknown	Not known; no or inclusive data	Insufficient data available; molecular wt low enough for possible excretion

No Known Risk

None

General	Excretion Potential	Effect on Infant	Notes
			None

Contraindicated

None

Precaution Exists

Bupropion

Hepatic-Lower doses are generally recommended in elderly. Bupropion is extensively metabolized to active metabolites, and the elderly may accumulate drug. Renal-Possible accumulation of active metabolites. Consider lower dose for GFR<90 mL/min and monitoring renal function. Neuro/Psych-Consider bupropion CNS side effects of dizziness, insomnia, somnolence and memory loss when using in the elderly.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	Y	Y	N	Y	N	N

BEERS: N     HEDIS: N     STOPP: N

No Known Risk

None

0-9	A-Z
F32.0	Major depressive disorder, single episode, mild
F32.1	Major depressive disorder, single episode, moderate
F32.2	Major depressive disorder, single episode, severe without psychotic features
F32.3	Major depressive disorder, single episode, severe with psychotic features
F32.4	Major depressive disorder, single episode, in partial remission
F32.5	Major depressive disorder, single episode, in full remission
F32.9	Major depressive disorder, single episode, unspecified
F33	Major depressive disorder, recurrent
F33.0	Major depressive disorder, recurrent, mild
F33.1	Major depressive disorder, recurrent, moderate
F33.2	Major depressive disorder, recurrent severe without psychotic features
F33.3	Major depressive disorder, recurrent, severe with psychotic symptoms
F33.4	Major depressive disorder, recurrent, in remission
F33.40	Major depressive disorder, recurrent, in remission, unspecified
F33.41	Major depressive disorder, recurrent, in partial remission
F33.42	Major depressive disorder, recurrent, in full remission
F33.9	Major depressive disorder, recurrent, unspecified