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Drug overview for AXTLE (pemetrexed dipotassium):
Generic name: PEMETREXED DIPOTASSIUM (PEM-e-TREX-ed)
Drug class: Folate Antagonists
Therapeutic class: Antineoplastics
No enhanced Introduction information available for this drug.
No enhanced Uses information available for this drug.
Generic name: PEMETREXED DIPOTASSIUM (PEM-e-TREX-ed)
Drug class: Folate Antagonists
Therapeutic class: Antineoplastics
No enhanced Introduction information available for this drug.
No enhanced Uses information available for this drug.
DRUG IMAGES
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The following indications for AXTLE (pemetrexed dipotassium) have been approved by the FDA:
Indications:
EGFR negative, ALK negative, non-small cell lung cancer
Malignant mesothelioma of pleura
Nonsquamous non-small cell lung cancer
Professional Synonyms:
EGFR-negative, ALK mut (-) non-small cell lung cancer
EGFR-negative, ALK-negative, NSCLC
Nonsquamous NSCLC
Indications:
EGFR negative, ALK negative, non-small cell lung cancer
Malignant mesothelioma of pleura
Nonsquamous non-small cell lung cancer
Professional Synonyms:
EGFR-negative, ALK mut (-) non-small cell lung cancer
EGFR-negative, ALK-negative, NSCLC
Nonsquamous NSCLC
The following dosing information is available for AXTLE (pemetrexed dipotassium):
No enhanced Dosing information available for this drug.
No enhanced Administration information available for this drug.
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| AXTLE 100 MG VIAL | Maintenance | Adults infuse 500 mg/m2 over 10 minute(s) by intravenous route on day 1 of a 21-day treatment cycle |
| AXTLE 500 MG VIAL | Maintenance | Adults infuse 500 mg/m2 over 10 minute(s) by intravenous route on day 1 of a 21-day treatment cycle |
No generic dosing information available.
The following drug interaction information is available for AXTLE (pemetrexed dipotassium):
There are 0 contraindications.
There are 0 severe interactions.
There are 0 moderate interactions.
The following contraindication information is available for AXTLE (pemetrexed dipotassium):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 4 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Chronic kidney disease stage 3B (moderate) GFR 30-44 ml/min |
| Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min |
| Chronic kidney disease stage 5 (failure) GFr<15 ml/min |
| Lactation |
There are 6 severe contraindications.
Adequate patient monitoring is recommended for safer drug use.
| Severe List |
|---|
| Anemia |
| Interstitial pneumonitis |
| Kidney disease with likely reduction in glomerular filtration rate (GFr) |
| Neutropenic disorder |
| Pregnancy |
| Thrombocytopenic disorder |
There are 0 moderate contraindications.
The following adverse reaction information is available for AXTLE (pemetrexed dipotassium):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 28 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Anemia Edema Leukopenia Neutropenic disorder Thrombocytopenic disorder Thromboembolic disorder |
Abnormal hepatic function tests Infection |
| Rare/Very Rare |
|---|
|
Autoimmune hemolytic anemia Bullous dermatitis Cardiac arrhythmia Colitis Erythema multiforme Esophagitis Exfoliative dermatitis Gastrointestinal obstruction Hypersensitivity drug reaction Hypertension Interstitial pneumonitis Pancreatitis Pulmonary thromboembolism Radiation recall syndrome Renal failure Sepsis Stevens-johnson syndrome Supraventricular arrhythmias Toxic epidermal necrolysis Ventricular tachycardia |
There are 26 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Abnormal desquamation Alopecia Anorexia Constipation Diarrhea Dyspnea Fatigue Headache disorder Nausea Pharyngitis Skin rash Stomatitis Vomiting |
Acute abdominal pain Chest pain Conjunctivitis Dehydration Dysgeusia Dyspepsia Eye tearing Fever Peripheral sensory neuropathy Pruritus of skin |
| Rare/Very Rare |
|---|
|
Depression Peripheral motor neuropathy Urticaria |
The following precautions are available for AXTLE (pemetrexed dipotassium):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
No enhanced Pregnancy information available for this drug.
No enhanced Lactation information available for this drug.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for AXTLE (pemetrexed dipotassium):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for AXTLE (pemetrexed dipotassium)'s list of indications:
| EGFR negative, ALK negative, non-small cell lung cancer | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| Malignant mesothelioma of pleura | |
| C45.0 | Mesothelioma of pleura |
| Nonsquamous non-small cell lung cancer | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
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