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SEMPREX-D (PSEUDOEPHEDRINE HCL/ACRIVASTINE)
- Allergic rhinitis
- Cold symptoms
- Nasal congestion
- Allergic conjunctivitis
- Perennial allergic rhinitis
- Rhinorrhea
- Seasonal allergic rhinitis
- Sneezing
- Vasomotor rhinitis
8 mg-60 mg capsule
- 1 capsule by oral route every 6 hours as needed
Nasal congestion
- 1 capsule by oral route every 4 hours as needed not to exceed 4 capsules per 24Hrs
- 1 capsule by oral route every 6 hours as needed
Rhinorrhea
- 1 capsule by oral route every 4 hours as needed not to exceed 4 capsules per 24Hrs
- 1 capsule by oral route every 6 hours as needed
Sneezing
- 1 capsule by oral route every 4 hours as needed not to exceed 4 capsules per 24Hrs
- 1 capsule by oral route every 6 hours as needed
- isocarboxazid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- tranylcypromine
Contraindicated
- Azilect
- bromocriptine
- cabergoline
- Cafergot
- Cycloset
- D.h.e.45
- dihydroergotamine
- Eldepryl
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- linezolid
- methylergonovine
- Migergot
- Migranal
- Parlodel
- rasagiline
- selegiline HCl
- Zelapar
- Zyvox
Severe
Moderate
- methyldopa
- methyldopa-hydrochlorothiazide
- methyldopate
- reserpine
- Angle-closure glaucoma
- Severe coronary artery disease
- Severe uncontrolled hypertension
- Urinary retention
Contraindicated
- Benign prostatic hyperplasia
- Diabetes mellitus
- Hypertension
- Hyperthyroidism
- Renal disease with moderate to severe impairment
Severe
Moderate
- None
SEMPREX-D (PSEUDOEPHEDRINE HCL/ACRIVASTINE)
- Allergic rhinitis
- Cold symptoms
- Nasal congestion
- Allergic conjunctivitis
- Perennial allergic rhinitis
- Rhinorrhea
- Seasonal allergic rhinitis
- Sneezing
- Vasomotor rhinitis
- None
- Dizziness
- Drowsy
- Headache disorder
- Insomnia
- Thick bronchial secretions
More Frequent
Severe
Less Severe
- None
- Agitation
- Anorexia
- Dizziness
- Drowsy
- Dysuria
- General weakness
- Nausea
- Nervousness
- Pallor
- Sedation
- Tachycardia
- Tremor
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute generalized exanthematous pustulosis
- Anaphylaxis
- Blood dyscrasias
- Dyspnea
- Extrasystoles
- Hallucinations
- Hemolytic anemia
- Hypertension
- Hypotension
- Ischemic colitis
- Seizure disorder
- Vomiting
Less Severe
- Abdominal distension
- Abdominal pain with cramps
- Acute abdominal pain
- Acute confusion
- Anorexia
- Ataxia
- Blurred vision
- Cardiac arrhythmia
- Chest discomfort
- Chills
- Constipation
- Diarrhea
- Diplopia
- Dry nose
- Dry throat
- Dyspepsia
- Dyspnea
- Dysuria
- Euphoria
- Excitement
- Fatigue
- Headache disorder
- Hyperhidrosis
- Insomnia
- Irritability
- Maculopapular rash
- Malaise
- Migraine
- Nervousness
- Nightmares
- Palpitations
- Paresthesia
- Pruritus of skin
- Skin photosensitivity
- Skin rash
- Symptoms of anxiety
- Tachycardia
- Tinnitus
- Tremor
- Urinary retention
- Urticaria
- Vertigo
- Visual changes
- Wheezing
- Xerostomia
Contraindicated
Pseudoephedrine (SR or High Dose)
Increased sensitivity to side effects. Dose form or strength not appropriate.
- 1 Day – 12 Years
- 1 Increased sensitivity to side effects. Dose form or strength not appropriate.
Severe Precaution
None
Management or Monitoring Precaution
Acrivastine
No pediatric safety and efficacy established age < 12 years.
- 1 Day – 12 Years
- No pediatric safety and efficacy established age < 12 years.
Acrivastine
- Severity Level:
B
- Additional Notes: Insufficient human data; no evidence of teratogenicity in rat and rabbit studies
Pseudoephedrine
- Severity Level:
C
- Additional Notes: Fda c w/combo prod; poss risk of gastroschisis/sia with 1st trimester exposure
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Acrivastine
Insufficient data available
May decrease milk supply, and cause irritability
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
Pseudoephedrine
Insufficient data available
May decrease milk supply, and cause irritability
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Drug shown to have adverse effect | May decrease milk supply, and cause irritability |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
Allergic conjunctivitis | |
H10.1 | Acute atopic conjunctivitis |
H10.10 | Acute atopic conjunctivitis, unspecified eye |
H10.11 | Acute atopic conjunctivitis, right eye |
H10.12 | Acute atopic conjunctivitis, left eye |
H10.13 | Acute atopic conjunctivitis, bilateral |
H10.44 | Vernal conjunctivitis |
H10.45 | Other chronic allergic conjunctivitis |
H16.26 | Vernal keratoconjunctivitis, with limbar and corneal involvement |
H16.261 | Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye |
H16.262 | Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye |
H16.263 | Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral |
H16.269 | Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye |
Allergic rhinitis | |
J30.1 | Allergic rhinitis due to pollen |
J30.2 | Other seasonal allergic rhinitis |
J30.5 | Allergic rhinitis due to food |
J30.8 | Other allergic rhinitis |
J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
J30.89 | Other allergic rhinitis |
J30.9 | Allergic rhinitis, unspecified |
Cold symptoms | |
J00 | Acute nasopharyngitis [common cold] |
Nasal congestion | |
R09.81 | Nasal congestion |
Perennial allergic rhinitis | |
J31.0 | Chronic rhinitis |
Rhinorrhea | |
R09.82 | Postnasal drip |
Seasonal allergic rhinitis | |
J30.1 | Allergic rhinitis due to pollen |
J30.2 | Other seasonal allergic rhinitis |
Sneezing | |
R06.7 | Sneezing |
Vasomotor rhinitis | |
J30.0 | Vasomotor rhinitis |
0-9 | A-Z |
---|---|
H10.1 | Acute atopic conjunctivitis |
H10.10 | Acute atopic conjunctivitis, unspecified eye |
H10.11 | Acute atopic conjunctivitis, right eye |
H10.12 | Acute atopic conjunctivitis, left eye |
H10.13 | Acute atopic conjunctivitis, bilateral |
H10.44 | Vernal conjunctivitis |
H10.45 | Other chronic allergic conjunctivitis |
H16.26 | Vernal keratoconjunctivitis, with limbar and corneal involvement |
H16.261 | Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye |
H16.262 | Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye |
H16.263 | Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral |
H16.269 | Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye |
J00 | Acute nasopharyngitis [common cold] |
J30.0 | Vasomotor rhinitis |
J30.1 | Allergic rhinitis due to pollen |
J30.1 | Allergic rhinitis due to pollen |
J30.2 | Other seasonal allergic rhinitis |
J30.2 | Other seasonal allergic rhinitis |
J30.5 | Allergic rhinitis due to food |
J30.8 | Other allergic rhinitis |
J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
J30.89 | Other allergic rhinitis |
J30.9 | Allergic rhinitis, unspecified |
J31.0 | Chronic rhinitis |
R06.7 | Sneezing |
R09.81 | Nasal congestion |
R09.82 | Postnasal drip |
Formulary Reference Tool