CEFPROZIL (cefprozil)

There are 0 contraindications.

There are 3 severe contraindications. Adequate patient monitoring is recommended for safer drug use.

Severe List
Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
Chronic kidney disease stage 5 (failure) GFr<15 ml/min
Clostridioides difficile infection

There are 2 moderate contraindications. Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.

Moderate List
Hypoprothrombinemia
Kidney disease with likely reduction in glomerular filtration rate (GFr)

There are 35 severe adverse reactions.

More Frequent	Less Frequent
None.	None.

Rare/Very Rare

Abnormal hepatic function tests Acute generalized exanthematous pustulosis Agranulocytosis Anaphylaxis Angioedema Aplastic anemia Candidiasis Cholestasis Clostridioides difficile infection Colitis DRESS syndrome Eosinophilia Erythema multiforme Hallucinations Hemolytic anemia Hemorrhage Hepatitis Hyperbilirubinemia Hypersensitivity drug reaction Hypoprothrombinemia Interstitial nephritis Jaundice Kidney disease with reduction in glomerular filtration rate (GFr) Myoclonus Obstructive hyperbilirubinemia Pancytopenia Pemphigus Pruritus of skin Renal failure Seizure disorder Serum sickness Stevens-johnson syndrome Thrombocytopenic disorder Toxic epidermal necrolysis Urticaria

There are 20 less severe adverse reactions.

More Frequent	Less Frequent
Acute abdominal pain Diarrhea Dyspepsia Nausea Vomiting	Gastritis Vulvovaginal candidiasis

Rare/Very Rare
Acute cognitive impairment Agitation Arthralgia Dizziness Drug fever Fatigue Genital organ pruritus Headache disorder Paresthesia Phlebitis after infusion Pruritus ani Skin rash Vaginitis

Reproduction studies in mice, rats, or rabbits using oral cefprozil in dosages 0.8, 8.5, or 18.5

times, respectively, the maximum daily human dose (1 g) based upon mg/m2 have not revealed evidence of harm to the fetus. There are no adequate and well-controlled studies to date using cefprozil in pregnant women or during labor and delivery, and the drug should be used during pregnancy or labor and delivery only when clearly needed.

Because trace concentrations of cefprozil (less than 0.3% of a dose) are distributed into milk, the drug should be used with caution in nursing women.

No enhanced Geriatric Use information available for this drug.