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ZESTORETIC (LISINOPRIL/HYDROCHLOROTHIAZIDE)
- Hypertension
10 mg-12.5 mg tablet
- 1 tablet by oral route once daily
20 mg-12.5 mg tablet
- 1 tablet by oral route once daily
20 mg-25 mg tablet
- 1 tablet by oral route once daily
lisinopril 10 mg-hydrochlorothiazide 12.5 mg tablet
- 1 tablet by oral route once daily
lisinopril 20 mg-hydrochlorothiazide 12.5 mg tablet
- 1 tablet by oral route once daily
lisinopril 20 mg-hydrochlorothiazide 25 mg tablet
- 1 tablet by oral route once daily
Hypertension
- 1 tablet by oral route once daily
- 2 tablets by oral route once daily
- dofetilide
- Tikosyn
Contraindicated
- aliskiren
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- aliskiren-hydrochlorothiazide
- Amturnide
- Curad Enema
- Disposable Enema
- Enema
- Enema Disposable
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- lithium carbonate
- lithium citrate
- Lithobid
- methenamine mand-sod biphos
- Oral Saline Laxative
- Osmoprep
- Phosphate Laxative
- Preparation Cleansing
- Ready-to-use Enema
- Reclast
- sod phos mono-sod phos dibasic
- sodium phosphates
- Tekamlo
- Tekturna
- Tekturna Hct
- Uroqid-acid No.2
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- acarbose
- Added Strength Headache Relief
- Added Strength Pain Reliever
- Alka-seltzer
- Alka-seltzer Extra Strength
- Alka-seltzer Original
- Alka-seltzer Plus C/c(pe,dm)
- Alka-seltzer Plus Cold (pe)
- Alka-seltzer Plus Day-night
- Alka-seltzer Plus Night
- Alka-seltzer Pm
- Amaryl
- Anacin
- Anacin Maximum Strength
- Analgesic
- Angeliq
- Antacid & Pain Relief
- Apidra
- Apidra Solostar
- ASA-acetaminophen-caff-buffers
- ASA-acetaminophen-salicyl-caff
- Ascomp With Codeine
- Aspir-trin
- aspirin
- aspirin, buffered
- aspirin-acetaminophen-caffeine
- aspirin-caffeine
- aspirin-diphenhydramine
- aspirin-diphenhydramine citrat
- aspirin-sod bicarb-citric acid
- Azasan
- azathioprine
- azathioprine sodium
- Back & Body Pain Reliever
- Bactrim
- Bactrim Ds
- Bayer Advanced
- Bayer Aspirin
- Bayer Aspirin (with Caffeine)
- Bayer Back & Body
- Bayer Plus Extra Strength
- Bayer Pm
- Bc
- Bc Arthritis
- Beyaz
- Buffered Aspirin
- Bufferin
- bumetanide
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-aspirin-caffeine
- carisoprodol-ASA-codeine
- carisoprodol-aspirin
- chlorphen-phenyleph-DM-aspirin
- chlorphenir-phenylephrn-aspirn
- cholestyramine (with sugar)
- Cholestyramine Light
- cholestyramine-aspartame
- codeine-butalbital-ASA-caff
- Cold Relief
- Cold Relief Plus
- Colestid
- Colestid Flavored
- colestipol
- Demadex
- Diabeta
- diazoxide
- Digox
- digoxin
- dihydrocodeine-aspirin-caff
- doxylamine-phenylep-DM-aspirin
- drospirenone-e.estradiol-lm.FA
- drospirenone-estradiol
- drospirenone-ethinyl estradiol
- Duetact
- E.c. Prin
- Ecotrin
- Efferves Pain Relief Antacid
- Effervescent Antacid
- Effervescent Pain Relief
- Effervescent Pain Reliever
- Endodan
- ethacrynate sodium
- Excedrin Extra Strength
- Excedrin Migraine
- Extra Strength Bayer
- Fiorinal
- Fiorinal-codeine #3
- furosemide
- Gianvi (28)
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Glyset
- Goody's Extra Strength
- Goody's Migraine Relief
- Headache Formula
- Headache Formula Added Str
- Headache Relief
- Humalog
- Humalog Kwikpen
- Humalog Mix 50-50
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 75-25 Kwikpen
- Humulin 70/30
- Humulin N
- Humulin N Kwikpen
- Humulin R
- Humulin R U-500 "Concentrated"
- Imuran
- insulin asp prt-insulin aspart
- insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin lispro
- insulin lispro protam-lispro
- insulin NPH and regular human
- insulin regular hum U-500 conc
- insulin regular human
- Lanoxin
- Lanoxin Pediatric
- Lantus
- Lantus Solostar
- Lasix
- Levacet
- Levemir
- Levemir Flexpen
- Lite Coat Aspirin
- Loryna (28)
- Medi-seltzer
- mercaptopurine
- miglitol
- Migraine Formula
- Migraine Pain Reliever
- Migraine Relief
- nateglinide
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- Ocella
- Orphenadrine Compound Forte
- Orphenadrine Compound-ds
- orphenadrine-ASA-caffeine
- oxycodone-aspirin
- Pain Relief
- Pain Relief Extra Strength
- Pain Reliever
- Pain Reliever Extra Strength
- Pain Reliever Plus
- Pain-off
- Pamprin Max
- PE-DM-ASA/doxyla-PE-DM-ASA
- Percodan
- pioglitazone-glimepiride
- Precose
- Prevalite
- Primsol
- Proglycem
- Purinethol
- Questran
- Questran Light
- Safyral
- Sodium Edecrin
- Starlix
- sulfamethoxazole-trimethoprim
- Sulfatrim
- Super Pain Relief
- Syeda
- Synalgos-dc
- tolazamide
- tolbutamide
- torsemide
- Tri-buffered Aspirin
- trimethoprim
- Vanquish
- Vestura (28)
- Yasmin (28)
- Yaz 28
- Zarah
- Angioedema
- Anuria
- Hereditary angioedema
- Intestinal angioedema
- Pregnancy
Contraindicated
- Abnormal hepatic function tests
- Acute pancreatitis
- Acute renal failure
- Azotemia
- Dehydration
- Gout
- Hepatic failure
- Hyperkalemia
- Hyperuricemia
- Hypochloremic alkalosis
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Hypotension
- Hypovolemia
- Neonatal hyperbilirubinemia
- Neutropenic disorder
- Renal artery stenosis
- Secondary angle-closure glaucoma
- SIADH syndrome
Severe
Moderate
- Aortic valve stenosis
- Basal cell carcinoma of skin
- Cerebrovascular insufficiency
- Diabetes mellitus
- Hypercalcemia
- Hypercholesterolemia
- Hyperparathyroidism
- Hypertrophic cardiomyopathy
- Kidney disease with likely reduction in GFR
- Renal dialysis
- Squamous cell carcinoma of skin
- Sympathectomy
- Systemic lupus erythematosus
ZESTORETIC (LISINOPRIL/HYDROCHLOROTHIAZIDE)
- Hypertension
- Hypochloremic alkalosis
- Hypokalemia
- Hyponatremia
- Hypotension
- Cough
- Dizziness
- Headache disorder
More Frequent
Severe
Less Severe
- Hyperglycemia
- Hyperkalemia
- Hypomagnesemia
- Kidney disease with reduction in GFR
- Abdominal pain with cramps
- Abnormal sexual function
- Anorexia
- Chest pain
- Constipation
- Diarrhea
- Dizziness
- Dysgeusia
- Erectile dysfunction
- Fatigue
- Flatulence
- General weakness
- Hypotension
- Nausea
- Orthostatic hypotension
- Skin rash
- Syncope
- Vomiting
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute hepatic failure
- Acute pancreatitis
- Acute renal failure
- Agranulocytosis
- Anaphylaxis
- Angioedema
- Aplastic anemia
- Bone marrow depression
- Diabetes mellitus
- Eosinophilia
- Erythema multiforme
- Exfoliative dermatitis
- Gout
- Head and neck angioedema
- Hemolytic anemia
- Hepatitis
- Hypercalcemia
- Hyperparathyroidism
- Hypersensitivity angiitis
- Hyperuricemia
- Hyponatremia
- Interstitial nephritis
- Interstitial pneumonitis
- Intestinal angioedema
- Jaundice
- Laryngeal edema
- Leukocytosis
- Leukopenia
- Myopia
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Orthostatic hypotension
- Purpura
- Secondary angle-closure glaucoma
- SIADH syndrome
- Squamous cell carcinoma of skin
- Stevens-johnson syndrome
- Systemic lupus erythematosus
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Urticaria
- Vasculitis
Less Severe
- Acute confusion
- Alopecia
- Arthralgias
- Arthritis
- Ataxia
- Basal cell carcinoma of skin
- Blurred vision
- Constipation
- Cutaneous pseudolymphoma
- Diplopia
- Erectile dysfunction
- Erythema
- Fever
- Flushing
- Gastrointestinal irritation
- General weakness
- Hallucinations
- Headache disorder
- Hypercholesterolemia
- Hypertriglyceridemia
- Mood changes
- Muscle spasm
- Nausea
- Nervousness
- Paresthesia
- Parosmia
- Photophobia
- Pruritus of skin
- Psoriasis
- Sialoadenitis
- Skin photosensitivity
- Skin rash
- Tinnitus
- Urticaria
- Vertigo
- Visual changes
- Xanthopsia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Lisinopril
No safety and efficacy data age < 6 years or in pediatric patients with GFR < 30 mL/minute /1.73m2.
- 1 Day – 6 Years
- No safety and efficacy data age < 6 years or in pediatric patients with GFR < 30 mL/minute /1.73m2.
Hydrochlorothiazide
- Severity Level:
B
- Additional Notes: Not recommended in pre-eclampsia and other pregnancy-induced hypertension.
Lisinopril
- Severity Level:
1
- Additional Notes: Fetal death/morbidity w/use in 2nd & 3rd trimester, stop when pregnancy detected
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Hydrochlorothiazide
Limited amounts excreted with no known adverse effects in infant.
Insufficient data available; manufacturer does not recommend
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited amounts excreted with no known adverse effects in infant. |
Lisinopril
Limited amounts excreted with no known adverse effects in infant.
Insufficient data available; manufacturer does not recommend
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available; manufacturer does not recommend |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Hydrochlorothiazide
Cardiovascular-Increased sensitivity to effects on blood pressure. Metabolic-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Endocrine-May exacerbate SIADH. May worsen glucose control in patients with diabetes. Renal-Not effective with CrCL < 30mL/min.
Cardiovascular-Peak plasma levels and AUC may be up to 2 times higher in the elderly. Monitor closely for hypotension especially after dose increases. Renal-Monitor for increased serum creatinine. Metabolic-Monitor for and manage hyperkalemia.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | Y |
BEERS: Y HEDIS: N STOPP: Y
Lisinopril
Cardiovascular-Increased sensitivity to effects on blood pressure. Metabolic-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Endocrine-May exacerbate SIADH. May worsen glucose control in patients with diabetes. Renal-Not effective with CrCL < 30mL/min.
Cardiovascular-Peak plasma levels and AUC may be up to 2 times higher in the elderly. Monitor closely for hypotension especially after dose increases. Renal-Monitor for increased serum creatinine. Metabolic-Monitor for and manage hyperkalemia.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- Lisinopril can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, tell your doctor right away.
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
Formulary Reference Tool