TRUQAP (capivasertib)
- HR(+), HER2(-), PIK3CA mutated advanced breast cancer
160 mg tablet
- Dosage information is not available
200 mg tablet
- 2 tablets (400 mg) by oral route 2 times per day for 4 days, followed by 3 days off
Default screening record
- 1 tablet (200 mg) by oral route 2 times per day for 4 days, followed by 3 days off
- 2 tablets (400 mg) by oral route 2 times per day for 4 days, followed by 3 days off
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- Camptosar
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- irinotecan
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- Ativan
- Conzip
- Dutoprol
- Juxtapid
- lomitapide
- Lopressor
- Lopressor Hct
- lorazepam
- Lorazepam Intensol
- metoprolol su-hydrochlorothiaz
- metoprolol succinate
- metoprolol ta-hydrochlorothiaz
- metoprolol tartrate
- Synapryn
- Toprol Xl
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- Ultracet
- Ultram
- Ultram Er
- Lactation
Contraindicated
- Hyperglycemia
- Pregnancy
Severe
Moderate
- Child-pugh class B hepatic impairment
- Disease of liver
TRUQAP (capivasertib)
- HR(+), HER2(-), PIK3CA mutated advanced breast cancer
- Acute kidney injury
- Acute renal failure
- Urinary tract infection
- Anemia
- Anorexia
- Diarrhea
- Eczema
- Fatigue
- Headache disorder
- Hyperglycemia
- Hypertriglyceridemia
- Hypocalcemia
- Hypokalemia
- Increased alanine transaminase
- Leukopenia
- Lymphopenia
- Nausea
- Neutropenic disorder
- Proteinuria
- Pruritus of skin
- Skin inflammation
- Skin rash
- Stomatitis
- Thrombocytopenic disorder
- Vomiting
More Frequent
Severe
Less Severe
- None
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- DRESS syndrome
- Erythema multiforme
- Palmar-plantar erythrodysesthesia
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Capivasertib
Safety and efficacy not established in pediatrics.
- 1 Day – 18 Years
- Safety and efficacy not established in pediatrics.
Capivasertib
- Severity Level:
D
- Additional Notes: Based on drug moa and animal data, developmental toxicity is possible
Contraindicated
Capivasertib
Mfr recommends avoiding breastfeeding during treatment
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Mfr recommends avoiding breastfeeding during treatment |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Capivasertib
General- In clinical trials, patients 65 years of age or older experienced a higher incidence of grade 3 to 5 adverse reactions leading to more dosage reductions, dose interruptions, and permanent discontinuations than younger patients. Endocrine- Optimize blood glucose prior to treatment and monitor fasting blood glucose more frequently. Gastrointestinal- Monitor for diarrhea and associated dehydration.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | N | N | N | Y |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
Hr(+), HEr2(-), PIk3CA mutated advanced breast cancer | |
C50 | Malignant neoplasm of breast |
C50.1 | Malignant neoplasm of central portion of breast |
C50.11 | Malignant neoplasm of central portion of breast, female |
C50.111 | Malignant neoplasm of central portion of right female breast |
C50.112 | Malignant neoplasm of central portion of left female breast |
C50.119 | Malignant neoplasm of central portion of unspecified female breast |
C50.12 | Malignant neoplasm of central portion of breast, male |
C50.121 | Malignant neoplasm of central portion of right male breast |
C50.122 | Malignant neoplasm of central portion of left male breast |
C50.129 | Malignant neoplasm of central portion of unspecified male breast |
C50.2 | Malignant neoplasm of upper-inner quadrant of breast |
C50.21 | Malignant neoplasm of upper-inner quadrant of breast, female |
C50.211 | Malignant neoplasm of upper-inner quadrant of right female breast |
C50.212 | Malignant neoplasm of upper-inner quadrant of left female breast |
C50.219 | Malignant neoplasm of upper-inner quadrant of unspecified female breast |
C50.22 | Malignant neoplasm of upper-inner quadrant of breast, male |
C50.221 | Malignant neoplasm of upper-inner quadrant of right male breast |
C50.222 | Malignant neoplasm of upper-inner quadrant of left male breast |
C50.229 | Malignant neoplasm of upper-inner quadrant of unspecified male breast |
C50.3 | Malignant neoplasm of lower-inner quadrant of breast |
C50.31 | Malignant neoplasm of lower-inner quadrant of breast, female |
C50.311 | Malignant neoplasm of lower-inner quadrant of right female breast |
C50.312 | Malignant neoplasm of lower-inner quadrant of left female breast |
C50.319 | Malignant neoplasm of lower-inner quadrant of unspecified female breast |
C50.32 | Malignant neoplasm of lower-inner quadrant of breast, male |
C50.321 | Malignant neoplasm of lower-inner quadrant of right male breast |
C50.322 | Malignant neoplasm of lower-inner quadrant of left male breast |
C50.329 | Malignant neoplasm of lower-inner quadrant of unspecified male breast |
C50.4 | Malignant neoplasm of upper-outer quadrant of breast |
C50.41 | Malignant neoplasm of upper-outer quadrant of breast, female |
C50.411 | Malignant neoplasm of upper-outer quadrant of right female breast |
C50.412 | Malignant neoplasm of upper-outer quadrant of left female breast |
C50.419 | Malignant neoplasm of upper-outer quadrant of unspecified female breast |
C50.42 | Malignant neoplasm of upper-outer quadrant of breast, male |
C50.421 | Malignant neoplasm of upper-outer quadrant of right male breast |
C50.422 | Malignant neoplasm of upper-outer quadrant of left male breast |
C50.429 | Malignant neoplasm of upper-outer quadrant of unspecified male breast |
C50.5 | Malignant neoplasm of lower-outer quadrant of breast |
C50.51 | Malignant neoplasm of lower-outer quadrant of breast, female |
C50.511 | Malignant neoplasm of lower-outer quadrant of right female breast |
C50.512 | Malignant neoplasm of lower-outer quadrant of left female breast |
C50.519 | Malignant neoplasm of lower-outer quadrant of unspecified female breast |
C50.52 | Malignant neoplasm of lower-outer quadrant of breast, male |
C50.521 | Malignant neoplasm of lower-outer quadrant of right male breast |
C50.522 | Malignant neoplasm of lower-outer quadrant of left male breast |
C50.529 | Malignant neoplasm of lower-outer quadrant of unspecified male breast |
C50.6 | Malignant neoplasm of axillary tail of breast |
C50.61 | Malignant neoplasm of axillary tail of breast, female |
C50.611 | Malignant neoplasm of axillary tail of right female breast |
C50.612 | Malignant neoplasm of axillary tail of left female breast |
C50.619 | Malignant neoplasm of axillary tail of unspecified female breast |
C50.62 | Malignant neoplasm of axillary tail of breast, male |
C50.621 | Malignant neoplasm of axillary tail of right male breast |
C50.622 | Malignant neoplasm of axillary tail of left male breast |
C50.629 | Malignant neoplasm of axillary tail of unspecified male breast |
C50.8 | Malignant neoplasm of overlapping sites of breast |
C50.81 | Malignant neoplasm of overlapping sites of breast, female |
C50.811 | Malignant neoplasm of overlapping sites of right female breast |
C50.812 | Malignant neoplasm of overlapping sites of left female breast |
C50.819 | Malignant neoplasm of overlapping sites of unspecified female breast |
C50.82 | Malignant neoplasm of overlapping sites of breast, male |
C50.821 | Malignant neoplasm of overlapping sites of right male breast |
C50.822 | Malignant neoplasm of overlapping sites of left male breast |
C50.829 | Malignant neoplasm of overlapping sites of unspecified male breast |
C50.9 | Malignant neoplasm of breast of unspecified site |
C50.91 | Malignant neoplasm of breast of unspecified site, female |
C50.911 | Malignant neoplasm of unspecified site of right female breast |
C50.912 | Malignant neoplasm of unspecified site of left female breast |
C50.919 | Malignant neoplasm of unspecified site of unspecified female breast |
C50.92 | Malignant neoplasm of breast of unspecified site, male |
C50.921 | Malignant neoplasm of unspecified site of right male breast |
C50.922 | Malignant neoplasm of unspecified site of left male breast |
C50.929 | Malignant neoplasm of unspecified site of unspecified male breast |
Z17.0 | Estrogen receptor positive status [Er+] |
Z19.1 | Hormone sensitive malignancy status |
0-9 | A-Z |
---|---|
C50 | Malignant neoplasm of breast |
C50.1 | Malignant neoplasm of central portion of breast |
C50.11 | Malignant neoplasm of central portion of breast, female |
C50.111 | Malignant neoplasm of central portion of right female breast |
C50.112 | Malignant neoplasm of central portion of left female breast |
C50.119 | Malignant neoplasm of central portion of unspecified female breast |
C50.12 | Malignant neoplasm of central portion of breast, male |
C50.121 | Malignant neoplasm of central portion of right male breast |
C50.122 | Malignant neoplasm of central portion of left male breast |
C50.129 | Malignant neoplasm of central portion of unspecified male breast |
C50.2 | Malignant neoplasm of upper-inner quadrant of breast |
C50.21 | Malignant neoplasm of upper-inner quadrant of breast, female |
C50.211 | Malignant neoplasm of upper-inner quadrant of right female breast |
C50.212 | Malignant neoplasm of upper-inner quadrant of left female breast |
C50.219 | Malignant neoplasm of upper-inner quadrant of unspecified female breast |
C50.22 | Malignant neoplasm of upper-inner quadrant of breast, male |
C50.221 | Malignant neoplasm of upper-inner quadrant of right male breast |
C50.222 | Malignant neoplasm of upper-inner quadrant of left male breast |
C50.229 | Malignant neoplasm of upper-inner quadrant of unspecified male breast |
C50.3 | Malignant neoplasm of lower-inner quadrant of breast |
C50.31 | Malignant neoplasm of lower-inner quadrant of breast, female |
C50.311 | Malignant neoplasm of lower-inner quadrant of right female breast |
C50.312 | Malignant neoplasm of lower-inner quadrant of left female breast |
C50.319 | Malignant neoplasm of lower-inner quadrant of unspecified female breast |
C50.32 | Malignant neoplasm of lower-inner quadrant of breast, male |
C50.321 | Malignant neoplasm of lower-inner quadrant of right male breast |
C50.322 | Malignant neoplasm of lower-inner quadrant of left male breast |
C50.329 | Malignant neoplasm of lower-inner quadrant of unspecified male breast |
C50.4 | Malignant neoplasm of upper-outer quadrant of breast |
C50.41 | Malignant neoplasm of upper-outer quadrant of breast, female |
C50.411 | Malignant neoplasm of upper-outer quadrant of right female breast |
C50.412 | Malignant neoplasm of upper-outer quadrant of left female breast |
C50.419 | Malignant neoplasm of upper-outer quadrant of unspecified female breast |
C50.42 | Malignant neoplasm of upper-outer quadrant of breast, male |
C50.421 | Malignant neoplasm of upper-outer quadrant of right male breast |
C50.422 | Malignant neoplasm of upper-outer quadrant of left male breast |
C50.429 | Malignant neoplasm of upper-outer quadrant of unspecified male breast |
C50.5 | Malignant neoplasm of lower-outer quadrant of breast |
C50.51 | Malignant neoplasm of lower-outer quadrant of breast, female |
C50.511 | Malignant neoplasm of lower-outer quadrant of right female breast |
C50.512 | Malignant neoplasm of lower-outer quadrant of left female breast |
C50.519 | Malignant neoplasm of lower-outer quadrant of unspecified female breast |
C50.52 | Malignant neoplasm of lower-outer quadrant of breast, male |
C50.521 | Malignant neoplasm of lower-outer quadrant of right male breast |
C50.522 | Malignant neoplasm of lower-outer quadrant of left male breast |
C50.529 | Malignant neoplasm of lower-outer quadrant of unspecified male breast |
C50.6 | Malignant neoplasm of axillary tail of breast |
C50.61 | Malignant neoplasm of axillary tail of breast, female |
C50.611 | Malignant neoplasm of axillary tail of right female breast |
C50.612 | Malignant neoplasm of axillary tail of left female breast |
C50.619 | Malignant neoplasm of axillary tail of unspecified female breast |
C50.62 | Malignant neoplasm of axillary tail of breast, male |
C50.621 | Malignant neoplasm of axillary tail of right male breast |
C50.622 | Malignant neoplasm of axillary tail of left male breast |
C50.629 | Malignant neoplasm of axillary tail of unspecified male breast |
C50.8 | Malignant neoplasm of overlapping sites of breast |
C50.81 | Malignant neoplasm of overlapping sites of breast, female |
C50.811 | Malignant neoplasm of overlapping sites of right female breast |
C50.812 | Malignant neoplasm of overlapping sites of left female breast |
C50.819 | Malignant neoplasm of overlapping sites of unspecified female breast |
C50.82 | Malignant neoplasm of overlapping sites of breast, male |
C50.821 | Malignant neoplasm of overlapping sites of right male breast |
C50.822 | Malignant neoplasm of overlapping sites of left male breast |
C50.829 | Malignant neoplasm of overlapping sites of unspecified male breast |
C50.9 | Malignant neoplasm of breast of unspecified site |
C50.91 | Malignant neoplasm of breast of unspecified site, female |
C50.911 | Malignant neoplasm of unspecified site of right female breast |
C50.912 | Malignant neoplasm of unspecified site of left female breast |
C50.919 | Malignant neoplasm of unspecified site of unspecified female breast |
C50.92 | Malignant neoplasm of breast of unspecified site, male |
C50.921 | Malignant neoplasm of unspecified site of right male breast |
C50.922 | Malignant neoplasm of unspecified site of left male breast |
C50.929 | Malignant neoplasm of unspecified site of unspecified male breast |
Z17.0 | Estrogen receptor positive status [Er+] |
Z19.1 | Hormone sensitive malignancy status |