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IMJUDO (tremelimumab-actl)
- EGFR negative, ALK negative, non-small cell lung cancer
- liver cell carcinoma
20 mg/mL intravenous solution
- Infuse 300 mg over 60 minute(s) by intravenous route once on day 1 ofcycle 1 of chemotherapy (for patients weighing 30 kg and greater)
Default screening record
- Infuse 300 mg over 60 minute(s) by intravenous route once on day 1 ofcycle 1 of chemotherapy (for patients weighing 30 kg and greater)
- Infuse 4 mg/kg over 60 minute(s) by intravenous route once on day 1 of cycle 1 of chemotherapy (for patients weighing <30 kg)
- None
Contraindicated
- None
Severe
Moderate
- None
- Intestinal perforation
- Lactation
Contraindicated
- Abnormal hepatic function tests
- Adrenocortical insufficiency
- Colitis
- Hypophysitis
- Interstitial pneumonitis
- Myocarditis
- Nephritis
- Pregnancy
Severe
Moderate
- Diabetes mellitus
- Hyperglycemia
- Hyperthyroidism
- Hypothyroidism
- Pancreatitis
IMJUDO (tremelimumab-actl)
- EGFR negative, ALK negative, non-small cell lung cancer
- liver cell carcinoma
- Anemia
- Hyperbilirubinemia
- Hyponatremia
- Increased alanine transaminase
- Increased alkaline phosphatase
- Increased aspartate transaminase
- Lymphopenia
- Acute abdominal pain
- Diarrhea
- Fatigue
- Musculoskeletal pain
- Pruritus of skin
- Skin rash
More Frequent
Severe
Less Severe
- Adrenocortical insufficiency
- Autoimmune hepatitis
- Colitis
- Hyperthyroidism
- Hypophysitis
- Hypothyroidism
- Interstitial nephritis
- Interstitial pneumonitis
- Pancreatitis
- Thyroiditis
- Hyperglycemia
- Skin inflammation
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute inflammatory syndrome
- Aplastic anemia
- Autoimmune encephalitis
- Autoimmune hemolytic anemia
- Autoimmune thrombocytopenia
- Demyelination
- Duodenitis
- Encephalitis
- Guillain-barre syndrome
- Hemophagocytic lymphohistiocytosis
- Histiocytic necrotizing lymphadenitis
- Hypoparathyroidism
- Iritis
- Meningitis
- Myocarditis
- Myositis
- Pericarditis
- Polymyalgia rheumatica
- Polymyositis
- Retinal detachment
- Rhabdomyolysis
- Sarcoidosis
- Uveitis
- Vasculitis
Less Severe
- Arthritis
- Gastritis
- Muscle weakness
- Peripheral sensory neuropathy
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Tremelimumab-actl
Safety and effectiveness not established in pediatric patients.
- 1 Day – 18 Years
- Safety and effectiveness not established in pediatric patients.
Tremelimumab-actl
- Severity Level:
D
- Additional Notes: Based on drug pharmacology, developmental toxicity is possible.
Contraindicated
Tremelimumab-actl
Mfr recommends to avoid during tx and for 3 month after the last dose
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Mfr recommends to avoid during tx and for 3 month after the last dose |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| EGFR negative, ALK negative, non-small cell lung cancer | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| Liver cell carcinoma | |
| C22.0 | Liver cell carcinoma |
| 0-9 | A-Z |
|---|---|
| C22.0 | Liver cell carcinoma |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
Formulary Reference Tool