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FASLODEX (FULVESTRANT)
- Hormone receptor + postmenopausal advanced breast cancer
- Hr(+), HEr2(-) advanced female breast cancer
250 mg/5 mL intramuscular syringe
- Inject 10 milliliters (500 mg) as 2 equally divided injections, one in each buttock, over 1-2 minute(s) by intramuscular route once a month
250 mg/5 mL intramuscular syringe
- Inject 10 milliliters (500 mg) as 2 equally divided injections, one in each buttock, over 1-2 minute(s) by intramuscular route once a month
Hormone receptor + postmenopausal advanced breast cancer
- Inject 10 milliliters (500 mg) as 2 equally divided injections, one into each buttock, over 1-2 minute(s) by intramuscular route every 14 days for 3 doses
- Inject 10 milliliters (500 mg) as 2 equally divided injections, one into each buttock, over 1-2 minute(s) by intramuscular route once a month
- Inject 10 milliliters (500 mg) as 2 equally divided injections, one in each buttock, over 1-2 minute(s) by intramuscular route once a month
Hr(+), HEr2(-) advanced female breast cancer
- Inject 10 milliliters (500 mg) as 2 equally divided injections, one into each buttock, over 1-2 minute(s) by intramuscular route every 14 days for 3 doses
- Inject 10 milliliters (500 mg) as 2 equally divided injections, one into each buttock, over 1-2 minute(s) by intramuscular route once a month
- Inject 10 milliliters (500 mg) as 2 equally divided injections, one in each buttock, over 1-2 minute(s) by intramuscular route once a month
- None
Contraindicated
- None
Severe
Moderate
- None
- Lactating mother
Contraindicated
- Disease of liver
- Increased risk of bleeding due to coagulation disorder
- Pregnancy
- Thrombocytopenic disorder
Severe
Moderate
- None
FASLODEX (FULVESTRANT)
- Hormone receptor + postmenopausal advanced breast cancer
- Hr(+), HEr2(-) advanced female breast cancer
- Infection
- Abnormal hepatic function tests
- Acute abdominal pain
- Anorexia
- Arthralgias
- Back pain
- Bone pain
- Chest pain
- Constipation
- Cough
- Depression
- Diarrhea
- Dizziness
- Drug-induced hot flash
- Dyspnea
- Fatigue
- Fever
- Flu-like symptoms
- General weakness
- Headache disorder
- Injection site sequelae
- Insomnia
- Musculoskeletal pain
- Nausea
- Pain
- Paresthesia
- Pelvic pain
- Peripheral edema
- Pharyngitis
- Pruritus of skin
- Skin rash
- Vasodilation of blood vessels
- Vomiting
More Frequent
Severe
Less Severe
- Increased alanine transaminase
- Increased aspartate transaminase
- Neutropenic disorder
- Accidental injury
- Anemia
- Arthritis
- Hyperhidrosis
- Symptoms of anxiety
- Urinary tract infection
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Angioedema
- Hepatic failure
- Hepatitis
- Hyperbilirubinemia
- Hypersensitivity drug reaction
- Leukopenia
- Thromboembolic disorder
Less Severe
- Abnormal vaginal bleeding
- Myalgias
- Neuralgia
- Neuropathic pain
- Peripheral neuropathy
- Urticaria
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Fulvestrant
Lack of efficacy for uterine and ovarian volume and predicted adult height in McCune-Albright Syndrome study in girls with precocious puberty.
- 1 Day – 18 Years
- Lack of efficacy for uterine and ovarian volume and predicted adult height in McCune-Albright Syndrome study in girls with precocious puberty.
Fulvestrant
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible
Contraindicated
Fulvestrant
Potential for serious adv effects, avoid nursing 1 yr after last dose
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Potential for serious adv effects, avoid nursing 1 yr after last dose |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
Hormone receptor + postmenopausal advanced breast cancer | |
C50.11 | Malignant neoplasm of central portion of breast, female |
C50.111 | Malignant neoplasm of central portion of right female breast |
C50.112 | Malignant neoplasm of central portion of left female breast |
C50.119 | Malignant neoplasm of central portion of unspecified female breast |
C50.21 | Malignant neoplasm of upper-inner quadrant of breast, female |
C50.211 | Malignant neoplasm of upper-inner quadrant of right female breast |
C50.212 | Malignant neoplasm of upper-inner quadrant of left female breast |
C50.219 | Malignant neoplasm of upper-inner quadrant of unspecified female breast |
C50.31 | Malignant neoplasm of lower-inner quadrant of breast, female |
C50.311 | Malignant neoplasm of lower-inner quadrant of right female breast |
C50.312 | Malignant neoplasm of lower-inner quadrant of left female breast |
C50.319 | Malignant neoplasm of lower-inner quadrant of unspecified female breast |
C50.41 | Malignant neoplasm of upper-outer quadrant of breast, female |
C50.411 | Malignant neoplasm of upper-outer quadrant of right female breast |
C50.412 | Malignant neoplasm of upper-outer quadrant of left female breast |
C50.419 | Malignant neoplasm of upper-outer quadrant of unspecified female breast |
C50.51 | Malignant neoplasm of lower-outer quadrant of breast, female |
C50.511 | Malignant neoplasm of lower-outer quadrant of right female breast |
C50.512 | Malignant neoplasm of lower-outer quadrant of left female breast |
C50.519 | Malignant neoplasm of lower-outer quadrant of unspecified female breast |
C50.61 | Malignant neoplasm of axillary tail of breast, female |
C50.611 | Malignant neoplasm of axillary tail of right female breast |
C50.612 | Malignant neoplasm of axillary tail of left female breast |
C50.619 | Malignant neoplasm of axillary tail of unspecified female breast |
C50.81 | Malignant neoplasm of overlapping sites of breast, female |
C50.811 | Malignant neoplasm of overlapping sites of right female breast |
C50.812 | Malignant neoplasm of overlapping sites of left female breast |
C50.819 | Malignant neoplasm of overlapping sites of unspecified female breast |
C50.91 | Malignant neoplasm of breast of unspecified site, female |
C50.911 | Malignant neoplasm of unspecified site of right female breast |
C50.912 | Malignant neoplasm of unspecified site of left female breast |
C50.919 | Malignant neoplasm of unspecified site of unspecified female breast |
Z17.0 | Estrogen receptor positive status [Er+] |
Z19.1 | Hormone sensitive malignancy status |
Hr(+), HEr2(-) advanced female breast cancer | |
C50 | Malignant neoplasm of breast |
C50.1 | Malignant neoplasm of central portion of breast |
C50.11 | Malignant neoplasm of central portion of breast, female |
C50.111 | Malignant neoplasm of central portion of right female breast |
C50.112 | Malignant neoplasm of central portion of left female breast |
C50.119 | Malignant neoplasm of central portion of unspecified female breast |
C50.2 | Malignant neoplasm of upper-inner quadrant of breast |
C50.21 | Malignant neoplasm of upper-inner quadrant of breast, female |
C50.211 | Malignant neoplasm of upper-inner quadrant of right female breast |
C50.212 | Malignant neoplasm of upper-inner quadrant of left female breast |
C50.219 | Malignant neoplasm of upper-inner quadrant of unspecified female breast |
C50.3 | Malignant neoplasm of lower-inner quadrant of breast |
C50.31 | Malignant neoplasm of lower-inner quadrant of breast, female |
C50.311 | Malignant neoplasm of lower-inner quadrant of right female breast |
C50.312 | Malignant neoplasm of lower-inner quadrant of left female breast |
C50.319 | Malignant neoplasm of lower-inner quadrant of unspecified female breast |
C50.4 | Malignant neoplasm of upper-outer quadrant of breast |
C50.41 | Malignant neoplasm of upper-outer quadrant of breast, female |
C50.411 | Malignant neoplasm of upper-outer quadrant of right female breast |
C50.412 | Malignant neoplasm of upper-outer quadrant of left female breast |
C50.419 | Malignant neoplasm of upper-outer quadrant of unspecified female breast |
C50.5 | Malignant neoplasm of lower-outer quadrant of breast |
C50.51 | Malignant neoplasm of lower-outer quadrant of breast, female |
C50.511 | Malignant neoplasm of lower-outer quadrant of right female breast |
C50.512 | Malignant neoplasm of lower-outer quadrant of left female breast |
C50.519 | Malignant neoplasm of lower-outer quadrant of unspecified female breast |
C50.6 | Malignant neoplasm of axillary tail of breast |
C50.61 | Malignant neoplasm of axillary tail of breast, female |
C50.611 | Malignant neoplasm of axillary tail of right female breast |
C50.612 | Malignant neoplasm of axillary tail of left female breast |
C50.619 | Malignant neoplasm of axillary tail of unspecified female breast |
C50.8 | Malignant neoplasm of overlapping sites of breast |
C50.81 | Malignant neoplasm of overlapping sites of breast, female |
C50.811 | Malignant neoplasm of overlapping sites of right female breast |
C50.812 | Malignant neoplasm of overlapping sites of left female breast |
C50.819 | Malignant neoplasm of overlapping sites of unspecified female breast |
C50.9 | Malignant neoplasm of breast of unspecified site |
C50.91 | Malignant neoplasm of breast of unspecified site, female |
C50.911 | Malignant neoplasm of unspecified site of right female breast |
C50.912 | Malignant neoplasm of unspecified site of left female breast |
C50.919 | Malignant neoplasm of unspecified site of unspecified female breast |
Z17.0 | Estrogen receptor positive status [Er+] |
Z19.1 | Hormone sensitive malignancy status |
0-9 | A-Z |
---|---|
C50 | Malignant neoplasm of breast |
C50.1 | Malignant neoplasm of central portion of breast |
C50.11 | Malignant neoplasm of central portion of breast, female |
C50.11 | Malignant neoplasm of central portion of breast, female |
C50.111 | Malignant neoplasm of central portion of right female breast |
C50.111 | Malignant neoplasm of central portion of right female breast |
C50.112 | Malignant neoplasm of central portion of left female breast |
C50.112 | Malignant neoplasm of central portion of left female breast |
C50.119 | Malignant neoplasm of central portion of unspecified female breast |
C50.119 | Malignant neoplasm of central portion of unspecified female breast |
C50.2 | Malignant neoplasm of upper-inner quadrant of breast |
C50.21 | Malignant neoplasm of upper-inner quadrant of breast, female |
C50.21 | Malignant neoplasm of upper-inner quadrant of breast, female |
C50.211 | Malignant neoplasm of upper-inner quadrant of right female breast |
C50.211 | Malignant neoplasm of upper-inner quadrant of right female breast |
C50.212 | Malignant neoplasm of upper-inner quadrant of left female breast |
C50.212 | Malignant neoplasm of upper-inner quadrant of left female breast |
C50.219 | Malignant neoplasm of upper-inner quadrant of unspecified female breast |
C50.219 | Malignant neoplasm of upper-inner quadrant of unspecified female breast |
C50.3 | Malignant neoplasm of lower-inner quadrant of breast |
C50.31 | Malignant neoplasm of lower-inner quadrant of breast, female |
C50.31 | Malignant neoplasm of lower-inner quadrant of breast, female |
C50.311 | Malignant neoplasm of lower-inner quadrant of right female breast |
C50.311 | Malignant neoplasm of lower-inner quadrant of right female breast |
C50.312 | Malignant neoplasm of lower-inner quadrant of left female breast |
C50.312 | Malignant neoplasm of lower-inner quadrant of left female breast |
C50.319 | Malignant neoplasm of lower-inner quadrant of unspecified female breast |
C50.319 | Malignant neoplasm of lower-inner quadrant of unspecified female breast |
C50.4 | Malignant neoplasm of upper-outer quadrant of breast |
C50.41 | Malignant neoplasm of upper-outer quadrant of breast, female |
C50.41 | Malignant neoplasm of upper-outer quadrant of breast, female |
C50.411 | Malignant neoplasm of upper-outer quadrant of right female breast |
C50.411 | Malignant neoplasm of upper-outer quadrant of right female breast |
C50.412 | Malignant neoplasm of upper-outer quadrant of left female breast |
C50.412 | Malignant neoplasm of upper-outer quadrant of left female breast |
C50.419 | Malignant neoplasm of upper-outer quadrant of unspecified female breast |
C50.419 | Malignant neoplasm of upper-outer quadrant of unspecified female breast |
C50.5 | Malignant neoplasm of lower-outer quadrant of breast |
C50.51 | Malignant neoplasm of lower-outer quadrant of breast, female |
C50.51 | Malignant neoplasm of lower-outer quadrant of breast, female |
C50.511 | Malignant neoplasm of lower-outer quadrant of right female breast |
C50.511 | Malignant neoplasm of lower-outer quadrant of right female breast |
C50.512 | Malignant neoplasm of lower-outer quadrant of left female breast |
C50.512 | Malignant neoplasm of lower-outer quadrant of left female breast |
C50.519 | Malignant neoplasm of lower-outer quadrant of unspecified female breast |
C50.519 | Malignant neoplasm of lower-outer quadrant of unspecified female breast |
C50.6 | Malignant neoplasm of axillary tail of breast |
C50.61 | Malignant neoplasm of axillary tail of breast, female |
C50.61 | Malignant neoplasm of axillary tail of breast, female |
C50.611 | Malignant neoplasm of axillary tail of right female breast |
C50.611 | Malignant neoplasm of axillary tail of right female breast |
C50.612 | Malignant neoplasm of axillary tail of left female breast |
C50.612 | Malignant neoplasm of axillary tail of left female breast |
C50.619 | Malignant neoplasm of axillary tail of unspecified female breast |
C50.619 | Malignant neoplasm of axillary tail of unspecified female breast |
C50.8 | Malignant neoplasm of overlapping sites of breast |
C50.81 | Malignant neoplasm of overlapping sites of breast, female |
C50.81 | Malignant neoplasm of overlapping sites of breast, female |
C50.811 | Malignant neoplasm of overlapping sites of right female breast |
C50.811 | Malignant neoplasm of overlapping sites of right female breast |
C50.812 | Malignant neoplasm of overlapping sites of left female breast |
C50.812 | Malignant neoplasm of overlapping sites of left female breast |
C50.819 | Malignant neoplasm of overlapping sites of unspecified female breast |
C50.819 | Malignant neoplasm of overlapping sites of unspecified female breast |
C50.9 | Malignant neoplasm of breast of unspecified site |
C50.91 | Malignant neoplasm of breast of unspecified site, female |
C50.91 | Malignant neoplasm of breast of unspecified site, female |
C50.911 | Malignant neoplasm of unspecified site of right female breast |
C50.911 | Malignant neoplasm of unspecified site of right female breast |
C50.912 | Malignant neoplasm of unspecified site of left female breast |
C50.912 | Malignant neoplasm of unspecified site of left female breast |
C50.919 | Malignant neoplasm of unspecified site of unspecified female breast |
C50.919 | Malignant neoplasm of unspecified site of unspecified female breast |
Z17.0 | Estrogen receptor positive status [Er+] |
Z17.0 | Estrogen receptor positive status [Er+] |
Z19.1 | Hormone sensitive malignancy status |
Z19.1 | Hormone sensitive malignancy status |
Formulary Reference Tool