XTANDI (ENZALUTAMIDE)
- Metastatic castration-resistant prostate cancer
- Non-metastatic castration-resistant prostate cancer
40 mg capsule
- 4 capsules (160 mg) by oral route once daily at the same time each day swallowing whole. Do not chew, open, dissolve and/or crush.
Metastatic castration-resistant prostate cancer
- 2 capsules (80 mg) by oral route once daily swallowing whole. Donot break, crush, dissolve and/or chew.
- 3 capsules (120 mg) by oral route once daily swallowing whole. Do not chew, open, dissolve and/or crush.
- 4 capsules (160 mg) by oral route once daily at the same time each day swallowing whole. Do not chew, open, dissolve and/or crush.
- 6 capsules (240 mg) by oral route once daily swallowing whole. Do not chew, open, dissolve and/or crush.
Non-metastatic castration-resistant prostate cancer
- 2 capsules (80 mg) by oral route once daily swallowing whole. Donot break, crush, dissolve and/or chew.
- 3 capsules (120 mg) by oral route once daily swallowing whole. Do not chew, open, dissolve and/or crush.
- 4 capsules (160 mg) by oral route once daily at the same time each day swallowing whole. Do not chew, open, dissolve and/or crush.
- 6 capsules (240 mg) by oral route once daily swallowing whole. Do not chew, open, dissolve and/or crush.
- Adalat Cc
- Afeditab Cr
- artemether-lumefantrine
- boceprevir
- Coartem
- Complera
- Edurant
- emtricitab-rilpivirine-tenofov
- Incivek
- Latuda
- lurasidone
- natalizumab
- Nifedical Xl
- nifedipine
- Procardia
- Procardia Xl
- rilpivirine
- telaprevir
- Tysabri
- Vfend
- Vfend Iv
- Victrelis
- voriconazole
Contraindicated
- Abstral
- Actiq
- Alfenta
- alfentanil
- amoxicil-clarithromy-lansopraz
- aprepitant
- Astagraf Xl
- Atripla
- axitinib
- B cplx-C-St.Johnwrt-K.&S.ginsg
- bedaquiline
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- bortezomib
- bosentan
- Bosulif
- bosutinib
- Brilinta
- cabozantinib
- Cafergot
- calcium-mag-B complex-D3-hrb61
- Caprelsa
- carbamazepine
- Carbatrol
- Cerebyx
- clarithromycin
- Cold & Flu Fighter
- Cometriq
- Coumadin
- crizotinib
- cyclosporine
- cyclosporine modified
- D.h.e.45
- dabrafenib
- dasatinib
- dextromethorphan-quinidine
- dihydroergotamine
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Duragesic
- efavirenz
- efavirenz-emtricitabin-tenofov
- Emend
- Epitol
- Equetro
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- erlotinib
- etravirine
- Fareston
- Fatigue Relief Complex
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- fosaprepitant
- fosphenytoin
- gemfibrozil
- Gengraf
- Gleevec
- guanfacine
- Hecoria
- ibrutinib
- imatinib
- Imbruvica
- Inlyta
- Intelence
- Intuniv Er
- isoniazid-rifamp-pyrazinamide
- Istodax
- ivacaftor
- Jantoven
- Jentadueto
- Kalydeco
- Korlym
- lapatinib
- Lazanda
- linagliptin
- linagliptin-metformin
- Lopid
- mefloquine
- mifepristone
- Migergot
- Migranal
- modafinil
- nafcillin
- nafcillin in dextrose iso-osm
- Neoral
- Nexavar
- nilotinib
- Nuedexta
- Olysio
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Orap
- pazopanib
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- Prevpac
- Prograf
- Provigil
- Qualaquin
- quetiapine
- quinidine gluconate
- quinidine sulfate
- quinine sulfate
- Rapamune
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- romidepsin
- Samsca
- Sandimmune
- Seroquel Xr
- simeprevir
- sirolimus
- Sirturo
- Soltamox
- sorafenib
- Sprycel
- St. John's wort
- Sublimaze (pf)
- Subsys
- sunitinib
- Sustiva
- Sutent
- tacrolimus
- Tafinlar
- tamoxifen
- Tarceva
- Tasigna
- Tegretol
- Tegretol Xr
- Tenex
- ticagrelor
- tolvaptan
- toremifene
- Tracleer
- Tradjenta
- Tykerb
- vandetanib
- Velcade
- vit C-St. John wort-elder-hb30
- Votrient
- warfarin
- Women's Complex
- Xalkori
Severe
Moderate
- A-hydrocort
- A-methapred
- Abilify
- Abilify Discmelt
- Abilify Maintena
- Adoxa
- alprazolam
- Alprazolam Intensol
- Anucort-hc
- Anusol-hc
- aripiprazole
- Aristospan Intra-articular
- Aristospan Intralesional
- Aromasin
- Astramorph-pf
- Ativan
- Avidoxy
- Avinza
- betamethasone acet & sod phos
- budesonide
- Buprenex
- buprenorphine
- buprenorphine-naloxone
- Butrans
- Celestone Soluspan
- Colocort
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Daliresp
- Depo-medrol
- Depodur (pf)
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diastat
- Diastat Acudial
- diazepam
- Diazepam Intensol
- Diskets
- Dolophine
- Doryx
- Doxy-100
- doxycycline calcium
- doxycycline hyclate
- doxycycline monohydrate
- Duramorph (pf)
- Entocort Ec
- exemestane
- Ez Use Joint-tunnel-trigger
- First-duke's
- First-mary's Mouthwash
- Flo-pred
- fludrocortisone
- Grx Hicort 25
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Hemril-30
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- Kadian
- Kenalog
- lorazepam
- Lorazepam Intensol
- macitentan
- Medrol
- Medrol (pak)
- methadone
- Methadone Intensol
- Methadose
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- midazolam
- midazolam (PF)
- Millipred
- Millipred Dp
- Monodox
- Morgidox
- morphine
- morphine (PF)
- morphine concentrate
- morphine liposomal (PF)
- Ms Contin
- Niravam
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Opsumit
- Oracea
- Orapred
- Orapred Odt
- ospemifene
- Osphena
- Pediapred
- Physicians Ez Use M-pred
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Proctocort
- Rayos
- Rectacort-hc
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- roflumilast
- Seroquel
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Suboxone
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- triazolam
- Uceris
- Valium
- Veripred 20
- Vibramycin
- Xanax
- Xanax Xr
- Zubsolv
- Lactating mother
- Posterior reversible encephalopathy syndrome
- Pregnancy
Contraindicated
- Cerebral trauma
- History of cerebrovascular accident
- Lower seizure threshold
- Seizure disorder
- Transient cerebral ischemia
Severe
Moderate
- Myocardial ischemia
XTANDI (ENZALUTAMIDE)
- Metastatic castration-resistant prostate cancer
- Non-metastatic castration-resistant prostate cancer
- Accidental fall
- Fracture
- Hypermagnesemia
- Hypertension
- Hyponatremia
- Lower respiratory infection
- Neutropenic disorder
- Anorexia
- Arthralgias
- Back pain
- Constipation
- Diarrhea
- Dizziness
- Dysgeusia
- Dyspnea
- Fatigue
- Flushing
- General weakness
- Headache disorder
- Hematuria
- Hyperglycemia
- Insomnia
- Muscle weakness
- Myalgias
- Nausea
- Paresthesia
- Peripheral edema
- Symptoms of anxiety
- Upper respiratory infection
- Weight loss
More Frequent
Severe
Less Severe
- Cauda equina syndrome
- Myocardial ischemia
- Spinal cord compression
- Acute confusion
- Disturbance of attention
- Dry skin
- Epistaxis
- Gynecomastia
- Hypesthesia
- Increased urinary frequency
- Memory impairment
- Muscle rigidity
- Pruritus of skin
- Restless legs syndrome
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Facial edema
- Hypersensitivity drug reaction
- Malignancy
- Pharyngeal edema
- Posterior reversible encephalopathy syndrome
- Seizure disorder
- Tongue swelling
Less Severe
- Skin rash
- Vomiting
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Enzalutamide
Not indicated in pediatrics. No safety and efficacy not studied.
- 1 Day – 18 Years
- Not indicated in pediatrics. No safety and efficacy not studied.
Enzalutamide
- Severity Level:
1
- Additional Notes: Insuff human data; based on pharmacology dev tox possible; ci in preg
Contraindicated
Enzalutamide
Not indicated for use in women
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Not indicated for use in women |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Enzalutamide
General-In clinical trials, falls and fractures occurred in 12% and 13% of patients. Median time to onset of fracture was 336 days. Evaluate fracture and fall risk. Gastrointestinal-May worsen existing constipation; evaluate bowel regimen.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
Metastatic castration-resistant prostate cancer | |
C61 | Malignant neoplasm of prostate |
Non-metastatic castration-resistant prostate cancer | |
C61 | Malignant neoplasm of prostate |
0-9 | A-Z |
---|---|
C61 | Malignant neoplasm of prostate |
C61 | Malignant neoplasm of prostate |