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PROGRAF (tacrolimus)
- Prevention of cardiac transplant rejection
- Prevention of kidney transplant rejection
- Prevention of liver transplant rejection
- Tacrolimus Capsule
- Prograf Oral Granules In Packet
- Prograf Intravenous Solution
- Prograf Capsule
- By Indication
0.5 mg capsule
- Dosage information is not available
1 mg capsule
- Dosage information is not available
5 mg capsule
- Dosage information is not available
0.2 mg oral granules in packet
- Dosage information is not available
1 mg oral granules in packet
- Dosage information is not available
5 mg/mL intravenous solution
- Infuse 0.0013 mg/kg/hour (0.03 mg/kg/day) by continuous infusion route
0.5 mg capsule
- Dosage information is not available
1 mg capsule
- Dosage information is not available
5 mg capsule
- Dosage information is not available
Prevention of cardiac transplant rejection
- Infuse 0.4166 mcg/kg/hour (0.01 mg/kg/day) by continuous infusion route
- 0.0375 mg/kg by oral route every 12 hours
- 0.0375 mg/kg mixed with 15-30 ml of water then immediately by oral route every 12 hours
Prevention of kidney transplant rejection
- Infuse 0.0013 mg/kg/hour (0.03 mg/kg/day) by continuous infusion route
- Infuse 0.0021 mg/kg/hour (0.05 mg/kg/day) by continuous infusion route
- 0.05 mg/kg by oral route every 12 hours
- 0.1 mg/kg by oral route every 12 hours
- 0.1 mg/kg mixed with 15-30 ml of water then immediately by oral route every 12 hours
- 0.05 mg/kg mixed with 15-30 ml of water then immediately byoral route every 12 hours
Prevention of liver transplant rejection
- Infuse 0.0013 mg/kg/hour (0.03 mg/kg/day) by continuous infusion route
- Infuse 0.0021 mg/kg/hour (0.05 mg/kg/day) by continuous infusion route
- 0.05 mg/kg by oral route every 12 hours
- 0.075 mg/kg by oral route every 12 hours
- 0.05 mg/kg mixed with 15-30 ml of water then immediately byoral route every 12 hours
- 0.075 mg/kg mixed with 15-30 ml of water then immediately by oral route every 12 hours
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- Aldactazide
- Aldactone
- amiloride
- amiloride-hydrochlorothiazide
- BCG vaccine, live (PF)
- cyclosporine
- cyclosporine modified
- Dyazide
- Dyrenium
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- Gengraf
- Geodon
- Korlym
- M-m-r Ii (pf)
- Maxzide
- Maxzide-25Mg
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- Mifeprex
- mifepristone
- natalizumab
- Neoral
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- Sandimmune
- spironolacton-hydrochlorothiaz
- spironolactone
- triamterene
- triamterene-hydrochlorothiazid
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- ziprasidone HCl
- ziprasidone mesylate
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- 1-day
- 3 Day Vaginal
- 3-day Vaginal
- Alagesic Lq
- amiodarone
- amiodarone in dextrose,iso-osm
- amobarbital
- amoxicil-clarithromy-lansopraz
- Amytal
- Aptivus
- artemether-lumefantrine
- Ascomp With Codeine
- atazanavir
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- butoconazole nitrate
- calcium-mag-B complex-D3-hrb61
- Capacet
- carbamazepine
- Carbatrol
- Cerebyx
- clarithromycin
- clotrimazole
- Clotrimazole 3 Day
- Clotrimazole-3
- Clotrimazole-7
- clozapine
- Clozaril
- Coartem
- codeine-butalbital-ASA-caff
- Cold & Flu Fighter
- Cordarone
- Crixivan
- crizotinib
- darunavir
- deferiprone
- Diflucan
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- disopyramide
- Donnatal
- droperidol
- enzalutamide
- Epitol
- Equetro
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- Esgic
- ethotoin
- Fatigue Relief Complex
- Fazaclo
- Ferriprox
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosamprenavir
- fosphenytoin
- Gynazole-1
- Gyne-lotrimin
- Gyne-lotrimin 7
- Incivek
- indinavir
- Invirase
- isoniazid-rifamp-pyrazinamide
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- Lexiva
- lopinavir-ritonavir
- Luminal
- Margesic
- Marten-tab
- miconazole
- Miconazole 7
- miconazole nitrate
- Miconazole-3
- Miconazole-3 Prefil,cream,wipe
- miconazole-skin clnsr17
- Monistat 1 Combo Pack
- Monistat 3
- Monistat 7
- Monistat 7 Cream, Appl, Wipes
- Mycobutin
- Mysoline
- nafcillin
- nafcillin in dextrose iso-osm
- nefazodone
- nelfinavir
- Nembutal Sodium
- Nexterone
- Norpace
- Norpace Cr
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- Orap
- Oravig
- Pacerone
- Peganone
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- posaconazole
- Prevpac
- Prezista
- Priftin
- primidone
- Rapamune
- Reyataz
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- ritonavir
- saquinavir mesylate
- secobarbital sodium
- Seconal Sodium
- sirolimus
- Sporanox
- Sporanox Pulsepak
- St. John's wort
- Tegretol
- Tegretol Xr
- telaprevir
- telithromycin
- temsirolimus
- Tencon
- thioridazine
- tioconazole
- Tioconazole-1
- tipranavir
- Torisel
- Vagistat-1
- Vagistat-3
- Versacloz
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- vit C-St. John wort-elder-hb30
- voriconazole
- Women's Complex
- Xalkori
- Xtandi
- Zebutal
Severe
Moderate
- Ablavar
- Aciphex
- Aciphex Sprinkle
- Adalat Cc
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- afatinib
- Afeditab Cr
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- alfuzosin
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Anaprox
- Anaprox Ds
- Ansaid
- Anzemet
- Apokyn
- apomorphine
- arsenic trioxide
- Arthrotec 50
- Atripla
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- bedaquiline
- Betapace
- Betapace Af
- Calan
- Calan Sr
- Caldolor
- Cambia
- Cancidas
- Caprelsa
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- caspofungin
- Cataflam
- Celexa
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- citalopram
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Complera
- danazol
- dasatinib
- Daypro
- Dexilant
- dexlansoprazole
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Duexis
- Ec-naprosyn
- Edurant
- efavirenz-emtricitabin-tenofov
- elvitegr-cobicist-emtric-tenof
- emtricitab-rilpivirine-tenofov
- emtricitabine-tenofovir
- eribulin
- ertapenem
- escitalopram oxalate
- esomeprazole magnesium
- esomeprazole sodium
- esomeprazole strontium
- etodolac
- ezogabine
- Fareston
- Feldene
- felodipine
- fenoprofen
- First-lansoprazole
- First-omeprazole
- Flanax
- Flector
- flurbiprofen
- gadofosveset trisodium
- Gilotrif
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Heartburn Relief 24 Hour
- Heartburn Treatment 24 Hour
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Invanz
- Invega
- Invega Sustenna
- Istodax
- Juxtapid
- ketoprofen
- ketorolac
- lansoprazole
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- levofloxacin
- levofloxacin in D5W
- Lexapro
- lomitapide
- Matzim La
- Medi-profen
- Mediproxen
- mefenamic acid
- methadone
- Methadone Intensol
- Methadose
- Midol (naproxen)
- Motrin Ib
- Motrin Pm
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- Nexavar
- Nexium
- Nexium Iv
- Nexium Packet
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Nifedical Xl
- nifedipine
- nilotinib
- norfloxacin
- Noroxin
- omeprazole
- omeprazole magnesium
- Omeprazole+syrspend Sf Alka
- omeprazole-sodium bicarbonate
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- oxaprozin
- paliperidone
- paliperidone palmitate
- pasireotide
- Pennsaid
- piroxicam
- Ponstel
- Potiga
- Prevacid
- Prevacid 24Hr
- Prevacid Solutab
- Prilosec
- Prilosec Otc
- Procardia
- Procardia Xl
- propafenone
- Provil
- pseudoephedrine-ibuprofen
- Qualaquin
- quetiapine
- quinine sulfate
- rabeprazole
- Reprexain
- rilpivirine
- romidepsin
- Rythmol
- Seroquel
- Seroquel Xr
- Signifor
- Sinus & Cold-d
- Sirturo
- Solaraze
- sorafenib
- Sorine
- sotalol
- Sotalol Af
- Sprix
- Sprycel
- Stribild
- sulindac
- Tarka
- Tasigna
- Taztia Xt
- telavancin
- tenofovir disoproxil fumarate
- tetrabenazine
- Tiazac
- Tikosyn
- tolmetin
- toremifene
- trandolapril-verapamil
- Trisenox
- Truvada
- Tykerb
- Uroxatral
- vandetanib
- vemurafenib
- verapamil
- Verelan
- Verelan Pm
- Vibativ
- Vicoprofen
- Vimovo
- Viread
- Voltaren-xr
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Xenazine
- Zegerid
- Zegerid Otc
- Zelboraf
- Zipsor
- Zofran
- Zofran Odt
- Zorvolex
- Zuplenz
- BK polyomavirus reactivation nephropathy
- Congenital long QT syndrome
- Malignant lymphoma
- Posterior reversible encephalopathy syndrome
- Progressive multifocal leukoencephalopathy
- Torsades de pointes
Contraindicated
- Bradycardia
- Chronic heart failure
- Coma
- Delirium
- Gastrointestinal perforation
- Hyperkalemia
- Hypocalcemia
- Hypokalemia
- Hypomagnesemia
- Malignancy
- Nephrotoxicity
- Post-transplant lymphoproliferative disease
- Pregnancy
- Prolonged QT interval
- Pure red cell aplasia
- Severe hepatic disease
- Severe infection
Severe
Moderate
- Diabetes mellitus
- Hypertension
PROGRAF (tacrolimus)
- Prevention of cardiac transplant rejection
- Prevention of kidney transplant rejection
- Prevention of liver transplant rejection
- Anemia
- Blood dyscrasias
- CNS toxicity
- Hallucinations
- Hyperglycemia
- Hyperkalemia
- Hypomagnesemia
- Infection
- Insomnia
- Kidney disease with reduction in GFR
- Leukopenia
- Nephrotoxicity
- Peripheral edema
- Pleural effusions
- Seizure disorder
- Acute abdominal pain
- Acute confusion
- Agitation
- Anorexia
- Constipation
- Depression
- Diabetes mellitus
- Diarrhea
- Dizziness
- Gastrointestinal irritation
- General weakness
- Hallucinations
- Headache disorder
- Insomnia
- Nausea
- Nervousness
- Nightmares
- Paresthesia
- Peripheral edema
- Pruritus of skin
- Skin rash
- Symptoms of anxiety
- Tremor
- Vomiting
More Frequent
Severe
Less Severe
- Cardiomyopathy
- Chest pain
- Dyspnea
- Fungal infection
- Hypercortisolism
- Hypertension
- Hypokalemia
- Kidney disease with reduction in GFR
- Osteoporosis
- Abdominal distension
- Acute abdominal pain
- Aphthous stomatitis
- Chest pain
- Cramps
- Dyspepsia
- Hyperhidrosis
- Hyperlipidemia
- Hypertriglyceridemia
- Hypesthesia
- Pain
- Paresthesia
- Peripheral neuropathy
- Peripheral sensory neuropathy
- Tinnitus
- Urinary tract infection
- Visual changes
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal ECG
- Abnormal hepatic function tests
- Acute pancreatitis
- Agranulocytosis
- Anaphylaxis
- Angina
- Aphasia
- Atrial fibrillation
- Atrial flutter
- Basal cell carcinoma of skin
- Biliary obstruction
- BK polyomavirus reactivation nephropathy
- Bradycardia
- Cardiac arrhythmia
- Cholangitis
- Chronic heart failure
- Coma
- Cytomegalovirus disease
- Deep venous thrombosis
- Disseminated intravascular coagulation
- Drug-induced hepatitis
- Drug-induced psychosis
- Encephalopathy
- Gastric ulcer
- Gastroenteritis
- Gastrointestinal perforation
- Hearing loss
- Hemiparesis
- Hemolytic anemia
- Hemolytic uremic syndrome
- Hemorrhage
- Hemorrhagic cystitis
- Hemorrhagic stroke
- Hepatic necrosis
- Hepatitis
- Hypertonia
- Hypertrophic cardiomyopathy
- Idiopathic thrombocytopenic purpura
- Increased alanine transaminase
- Increased aspartate transaminase
- Interstitial lung disease
- Left ventricular hypertrophy
- Leukocytosis
- Leukoencephalopathy
- Malignant lymphoma
- Myoclonus
- Neutropenic disorder
- Optic neuropathy
- Pancreatitis
- Pancytopenia
- Paralysis
- Pericardial effusion
- Peripheral motor neuropathy
- Post-transplant lymphoproliferative disease
- Posterior reversible encephalopathy syndrome
- Progressive multifocal leukoencephalopathy
- Prolonged QT interval
- Pulmonary hypertension
- Pulmonary thromboembolism
- Pure red cell aplasia
- Renal failure
- Rhabdomyolysis
- Squamous cell carcinoma
- Stevens-johnson syndrome
- Supraventricular premature beats
- Thrombocytopenic disorder
- Thrombotic thrombocytopenic purpura
- Torsades de pointes
- Toxic epidermal necrolysis
- Transient blindness
- Urinary retention
- Ventricular fibrillation
- Viral infection
- Vision loss
Less Severe
- Altered mental status
- Arthritis
- Ataxia
- Carpal tunnel syndrome
- Cramps in legs
- Delirium
- Disturbance in thinking
- Drowsy
- Dysarthria
- Gastritis
- Glycosuria
- Hearing loss
- Hematuria
- Hiccups
- Impaired wound healing
- Limb pain
- Memory impairment
- Mood changes
- Myalgias
- Neuralgia
- Photophobia
- Rhinitis
- Skin photosensitivity
- Skin pigmentation enhancement
- Slurred speech
- Syncope
- Tachycardia
- Treatment site sequelae
- Urinary incontinence
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Tacrolimus (systemic)
- Severity Level:
D
- Additional Notes: Avail human data suggest increased risk of dev tox; consider risk vs benefit
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Tacrolimus (systemic)
Limited data suggest minimal excretion; no known adverse infant effects
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest minimal excretion; no known adverse infant effects |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Tacrolimus (systemic)
Cardiovascular-Risk of myocardial hypertrophy can occur. May require reduced dose. General-Altered pharmacokinetics may occur and require more frequent monitoring.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Tacrolimus lowers the body's ability to fight an infection/disease (immunosuppression). This may increase your risk of developing an infection or certain types of cancer (e.g., skin cancer, lymphoma). To reduce the risk of these serious side effects, take this medication at the lowest effective dose as directed by your doctor.<br /><br />Keep all medical and laboratory appointments. Tell your doctor right away if you develop any of the following: unusual skin changes, change in the appearance/size of moles, unusual growths/lumps, swollen glands, night sweats, unexplained weight loss, signs of infection (e.g., fever, persistent sore throat).
| Prevention of cardiac transplant rejection | |
| Z94.1 | Heart transplant status |
| Z94.3 | Heart and lungs transplant status |
| Prevention of kidney transplant rejection | |
| Z94.0 | Kidney transplant status |
| Prevention of liver transplant rejection | |
| Z94.4 | Liver transplant status |
| 0-9 | A-Z |
|---|---|
| Z94.0 | Kidney transplant status |
| Z94.1 | Heart transplant status |
| Z94.3 | Heart and lungs transplant status |
| Z94.4 | Liver transplant status |
Formulary Reference Tool