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PADCEV (enfortumab vedotin-ejfv)
- Transitional cell carcinoma of the urinary tract
20 mg intravenous solution
- Infuse 1.25 mg/kg (not to exceed 125 mg) over 30 minute(s) by intravenous route on days 1, 8 and 15 of a 28 day cycle
30 mg intravenous solution
- Infuse 1.25 mg/kg (not to exceed 125 mg) over 30 minute(s) by intravenous route on days 1, 8 and 15 of a 28 day cycle
Transitional cell carcinoma of the urinary tract
- Infuse 1.25 mg/kg (not to exceed 125 mg) over 30 minute(s) by intravenous route on days 1, 8 and 15 of a 28 day cycle
- Infuse 1 mg/kg (not to exceed 100 mg) over 30 minute(s) by intravenous route on days 1, 8 and 15 of a 28 day cycle
- Infuse 0.75 mg/kg (not to exceed 75 mg) over 30 minute(s) by intravenous route on days 1, 8 and 15 of a 28 day cycle
- Infuse 0.5 mg/kg (not to exceed 50 mg) over 30 minute(s) by intravenous route on days 1, 8 and 15 of a 28 day cycle
- None
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- None
Severe
Moderate
- None
PADCEV (enfortumab vedotin-ejfv)
- Transitional cell carcinoma of the urinary tract
- None
- None
More Frequent
Severe
Less Severe
- None
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- None
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Enfortumab Vedotin-ejfv
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Enfortumab Vedotin-ejfv
General-Older adults experienced a higher incidence of serious and fatal adverse reactions than younger patients when enfortumab vedotin-ejfv was used as a single agent.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
Transitional cell carcinoma of the urinary tract | |
C65 | Malignant neoplasm of renal pelvis |
C65.1 | Malignant neoplasm of right renal pelvis |
C65.2 | Malignant neoplasm of left renal pelvis |
C65.9 | Malignant neoplasm of unspecified renal pelvis |
C66 | Malignant neoplasm of ureter |
C66.1 | Malignant neoplasm of right ureter |
C66.2 | Malignant neoplasm of left ureter |
C66.9 | Malignant neoplasm of unspecified ureter |
C67 | Malignant neoplasm of bladder |
C67.0 | Malignant neoplasm of trigone of bladder |
C67.1 | Malignant neoplasm of dome of bladder |
C67.2 | Malignant neoplasm of lateral wall of bladder |
C67.3 | Malignant neoplasm of anterior wall of bladder |
C67.4 | Malignant neoplasm of posterior wall of bladder |
C67.5 | Malignant neoplasm of bladder neck |
C67.6 | Malignant neoplasm of ureteric orifice |
C67.8 | Malignant neoplasm of overlapping sites of bladder |
C67.9 | Malignant neoplasm of bladder, unspecified |
0-9 | A-Z |
---|---|
C65 | Malignant neoplasm of renal pelvis |
C65.1 | Malignant neoplasm of right renal pelvis |
C65.2 | Malignant neoplasm of left renal pelvis |
C65.9 | Malignant neoplasm of unspecified renal pelvis |
C66 | Malignant neoplasm of ureter |
C66.1 | Malignant neoplasm of right ureter |
C66.2 | Malignant neoplasm of left ureter |
C66.9 | Malignant neoplasm of unspecified ureter |
C67 | Malignant neoplasm of bladder |
C67.0 | Malignant neoplasm of trigone of bladder |
C67.1 | Malignant neoplasm of dome of bladder |
C67.2 | Malignant neoplasm of lateral wall of bladder |
C67.3 | Malignant neoplasm of anterior wall of bladder |
C67.4 | Malignant neoplasm of posterior wall of bladder |
C67.5 | Malignant neoplasm of bladder neck |
C67.6 | Malignant neoplasm of ureteric orifice |
C67.8 | Malignant neoplasm of overlapping sites of bladder |
C67.9 | Malignant neoplasm of bladder, unspecified |
Formulary Reference Tool