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LEDIPASVIR-SOFOSBUVIR (ledipasvir/sofosbuvir)
- Chronic hepatitis C - genotype 1
- Chronic hepatitis C - genotype 4
- Chronic hepatitis C - genotype 5
- Chronic hepatitis C - genotype 6
ledipasvir 45 mg-sofosbuvir 200 mg tablet
- Dosage information is not available
ledipasvir 90 mg-sofosbuvir 400 mg tablet
- 1 tablet by oral route once daily
45 mg-200 mg tablet
- Dosage information is not available
90 mg-400 mg tablet
- 1 tablet by oral route once daily
Chronic hepatitis C - genotype 1
- 1 tablet by oral route once daily
- 1 tablet by oral route once daily for 8 weeks
- 1 tablet by oral route once daily for 12 weeks
- 1 tablet by oral route once daily for 24 weeks
Chronic hepatitis C - genotype 4
- 1 tablet by oral route once daily
- 1 tablet by oral route once daily for 12 weeks
Chronic hepatitis C - genotype 5
- 1 tablet by oral route once daily
- 1 tablet by oral route once daily for 12 weeks
Chronic hepatitis C - genotype 6
- 1 tablet by oral route once daily
- 1 tablet by oral route once daily for 12 weeks
- Aptivus
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- Cold & Flu Fighter
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- Epitol
- Equetro
- Fatigue Relief Complex
- fosphenytoin
- isoniazid-rifamp-pyrazinamide
- Luminal
- Mycobutin
- Mysoline
- oxcarbazepine
- Oxtellar Xr
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Priftin
- primidone
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- St. John's wort
- Tegretol
- Tegretol Xr
- tipranavir
- Trileptal
- vit C-St. John wort-elder-hb30
- Women's Complex
Contraindicated
- Hycamtin
- topotecan
Severe
Moderate
- afatinib
- Afinitor
- Afinitor Disperz
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- Diamode
- everolimus
- Gilotrif
- Imodium Multi-symptom Relief
- Lo-peramide
- loperamide
- loperamide-simethicone
- Ultra A-d
- Zortress
- None
Contraindicated
- None
Severe
Moderate
- Reactivation of hepatitis B
LEDIPASVIR-SOFOSBUVIR (ledipasvir/sofosbuvir)
- Chronic hepatitis C - genotype 1
- Chronic hepatitis C - genotype 4
- Chronic hepatitis C - genotype 5
- Chronic hepatitis C - genotype 6
- None
- Fatigue
- General weakness
- Headache disorder
- Nausea
More Frequent
Severe
Less Severe
- None
- Diarrhea
- Dizziness
- Hyperbilirubinemia
- Insomnia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute occlusion of mesenteric vein
- Angioedema
- Gout
- Hypertension
- Reactivation of hepatitis B
- Urinary retention
Less Severe
- Abdominal distension
- Acne vulgaris
- Acute abdominal pain
- Alopecia
- Anorexia
- Arthralgias
- Blistering skin
- Bruising
- Conjunctivitis
- Constipation
- Depression
- Disturbance of attention
- Edema
- Erectile dysfunction
- Gastroesophageal reflux disease
- Hyperhidrosis
- Irritability
- Libido changes
- Muscle spasm
- Muscle weakness
- Nasal congestion
- Pain in oropharynx
- Palpitations
- Pruritus of skin
- Salpingitis
- Sinusitis
- Skin rash
- Sleep disorder
- Sprains and strains
- Symptoms of anxiety
- Visual changes
- Vomiting
- Weight loss
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Sofosbuvir
Safety and efficacy have not been established in patients < 3 years.
- 1 Day – 3 Years
- Safety and efficacy have not been established in patients < 3 years.
Ledipasvir/sofosbuvir
- Severity Level:
2
- Additional Notes: Insufficient human data available; animal data show no developmental toxicity
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Ledipasvir/sofobusvir
Insufficient human data available
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Although this medication helps many people with hepatitis C, it may cause people who also have another liver problem called hepatitis B to get worse. Before starting this medication, tell your doctor if you have ever had hepatitis B. Tell your doctor right away if you have new or worsening symptoms of liver disease, such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, dark urine or yellowing eyes/skin.
Chronic hepatitis C - genotype 1 | |
B18.2 | Chronic viral hepatitis C |
Chronic hepatitis C - genotype 4 | |
B18.2 | Chronic viral hepatitis C |
Chronic hepatitis C - genotype 5 | |
B18.2 | Chronic viral hepatitis C |
Chronic hepatitis C - genotype 6 | |
B18.2 | Chronic viral hepatitis C |
0-9 | A-Z |
---|---|
B18.2 | Chronic viral hepatitis C |
B18.2 | Chronic viral hepatitis C |
B18.2 | Chronic viral hepatitis C |
B18.2 | Chronic viral hepatitis C |
Formulary Reference Tool