FOSFOMYCIN TROMETHAMINE (fosfomycin tromethamine)

There are 0 contraindications.

There are 1 severe contraindications. Adequate patient monitoring is recommended for safer drug use.

Severe List
Clostridioides difficile infection

There are 1 moderate contraindications. Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.

Moderate List
Kidney disease with reduction in glomerular filtration rate (GFr)

There are 2 severe adverse reactions.

More Frequent	Less Frequent
Vaginitis	None.

Rare/Very Rare
Clostridioides difficile infection

There are 13 less severe adverse reactions.

More Frequent	Less Frequent
Diarrhea Headache disorder Nausea	Abdominal pain with cramps Back pain Dizziness Dysmenorrhea Dyspepsia General weakness Pain Pharyngitis Rhinitis Skin rash

Rare/Very Rare
None.

There are no adequate and well-controlled studies using fosfomycin in pregnant women. Fosfomycin should be used during pregnancy only if clearly needed.

It is not known whether fosfomycin is distributed into milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or not administer fosfomycin, taking into account the importance of the drug to the woman.

Clinical studies of fosfomycin did not include sufficient numbers of patients 65 years of age or older to determine whether geriatric patients respond differently than younger patients. Although other clinical experience has not identified age-related differences in response or tolerance, dosage for geriatric patients should be selected with caution and the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy in this age group should be considered.