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Drug overview for BETHANECHOL CHLORIDE (bethanechol chloride):
Generic name: BETHANECHOL CHLORIDE (be-THAN-e-kol)
Drug class: Urinary Antispasmodics
Therapeutic class: Genitourinary Therapy
Bethanechol is a cholinergic drug that is related to acetylcholine.
No enhanced Uses information available for this drug.
Generic name: BETHANECHOL CHLORIDE (be-THAN-e-kol)
Drug class: Urinary Antispasmodics
Therapeutic class: Genitourinary Therapy
Bethanechol is a cholinergic drug that is related to acetylcholine.
No enhanced Uses information available for this drug.
DRUG IMAGES
BETHANECHOL 10 MG TABLET
BETHANECHOL 25 MG TABLET
BETHANECHOL 50 MG TABLET
BETHANECHOL 5 MG TABLET
The following indications for BETHANECHOL CHLORIDE (bethanechol chloride) have been approved by the FDA:
Indications:
Urinary retention
Professional Synonyms:
Retention of urine
Indications:
Urinary retention
Professional Synonyms:
Retention of urine
The following dosing information is available for BETHANECHOL CHLORIDE (bethanechol chloride):
Dosage of bethanechol chloride must be individualized according to the type and severity of the condition being treated.
Bethanechol chloride is administered orally. Bethanechol chloride should be administered on an empty stomach (e.g., 1 hour before or 2 hours after a meal) to minimize nausea and vomiting. Bethanechol chloride also has been administered by subcutaneous injection.
However, a parenteral dosage form no longer is commercially available in the US. Bethanechol chloride tablets should be stored in tight, light-resistant containers at a temperature of 20-25degreesC (excursions permitted between 15-30degreesC).
However, a parenteral dosage form no longer is commercially available in the US. Bethanechol chloride tablets should be stored in tight, light-resistant containers at a temperature of 20-25degreesC (excursions permitted between 15-30degreesC).
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| BETHANECHOL 5 MG TABLET | Maintenance | Adults take 2 tablets (10 mg) by oral route 4 times per day on an empty stomach, 1 hour before or 2 hours after a meal |
| BETHANECHOL 10 MG TABLET | Maintenance | Adults take 1 tablet (10 mg) by oral route 4 times per day on an empty stomach, 1 hour before or 2 hours after a meal |
| BETHANECHOL 25 MG TABLET | Maintenance | Adults take 1 tablet (25 mg) by oral route 4 times per day on an empty stomach, 1 hour before or 2 hours after a meal |
| BETHANECHOL 50 MG TABLET | Maintenance | Adults take 1 tablet (50 mg) by oral route 4 times per day on an empty stomach, 1 hour before or 2 hours after a meal |
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| BETHANECHOL 5 MG TABLET | Maintenance | Adults take 2 tablets (10 mg) by oral route 4 times per day on an empty stomach, 1 hour before or 2 hours after a meal |
| BETHANECHOL 10 MG TABLET | Maintenance | Adults take 1 tablet (10 mg) by oral route 4 times per day on an empty stomach, 1 hour before or 2 hours after a meal |
| BETHANECHOL 25 MG TABLET | Maintenance | Adults take 1 tablet (25 mg) by oral route 4 times per day on an empty stomach, 1 hour before or 2 hours after a meal |
| BETHANECHOL 50 MG TABLET | Maintenance | Adults take 1 tablet (50 mg) by oral route 4 times per day on an empty stomach, 1 hour before or 2 hours after a meal |
The following drug interaction information is available for BETHANECHOL CHLORIDE (bethanechol chloride):
There are 0 contraindications.
There are 0 severe interactions.
There are 1 moderate interactions.
The clinician should assess the patient’s characteristics and take action as needed. Actions required for moderate interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration.
| Drug Interaction | Drug Names |
|---|---|
| Cholinergics/Quinidine SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: The anticholinergic properties of quinidine may oppose cholinergic drug effects. CLINICAL EFFECTS: Quinidine may antagonize the effects of cholinergic drugs in the treatment of myasthenia gravis. Cardiac slowing secondary to cholinergic drugs would tend to be prevented by quinidine. PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: If both drugs are administered, observe the myasthenic patient for signs and symptoms of the disease. DISCUSSION: Caution is warranted in co-administration of these drugs due to their opposing pharmacologic properties. |
NUEDEXTA, QUINIDINE GLUCONATE, QUINIDINE SULFATE |
The following contraindication information is available for BETHANECHOL CHLORIDE (bethanechol chloride):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 17 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Abnormal vasomotor function |
| Bladder outflow obstruction |
| Bladder surgery |
| Coronary artery disease |
| Gastrointestinal obstruction |
| Gastrointestinal tract surgery |
| Hyperthyroidism |
| Hypotension |
| Increased gastric tonus |
| Inflammatory bowel disease |
| Intestinal anastomosis |
| Irritable bowel syndrome |
| Parkinsonism |
| Peptic ulcer |
| Peritonitis |
| Seizure disorder |
| Urinary tract obstructive uropathy |
There are 3 severe contraindications.
Adequate patient monitoring is recommended for safer drug use.
| Severe List |
|---|
| Asthma |
| Bradycardia |
| Orthostatic hypotension |
There are 2 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| Atrioventricular block |
| Hypertension |
The following adverse reaction information is available for BETHANECHOL CHLORIDE (bethanechol chloride):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 3 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. | None. |
| Rare/Very Rare |
|---|
|
Chest tightness Dyspnea Wheezing |
There are 5 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. | None. |
| Rare/Very Rare |
|---|
|
Blurred vision Diarrhea Eructation Increased urinary frequency Visual changes |
The following precautions are available for BETHANECHOL CHLORIDE (bethanechol chloride):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
Animal reproduction studies have not been performed with bethanechol chloride, and it is not known whether the drug can cause fetal harm when administered to pregnant women. Bethanechol should be used during pregnancy only when clearly needed.
It is not known whether bethanechol is distributed into milk. Because many drugs are distributed into milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or bethanechol, taking into account the importance of the drug to the woman.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for BETHANECHOL CHLORIDE (bethanechol chloride):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for BETHANECHOL CHLORIDE (bethanechol chloride)'s list of indications:
| Urinary retention | |
| R33 | Retention of urine |
| R33.8 | Other retention of urine |
| R33.9 | Retention of urine, unspecified |
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