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ALYMSYS (bevacizumab-maly)
- colon and rectal cancer that has spread to another area
- metastatic renal cell carcinoma
- nonsquamous non-small cell lung cancer
- carcinoma cancer of the cervix
- epithelial cancer of ovary
- glioblastoma multiforme
25 mg/mL intravenous solution
- Infuse 5 mg/kg over 30 minute(s) by intravenous route every 2 weeks
Default screening record
- Infuse 5 mg/kg over 90 minute(s) by intravenous route every 2 weeks
- Infuse 10 mg/kg over 90 minute(s) by intravenous route every 2 weeks
- Infuse 15 mg/kg over 90 minute(s) by intravenous route every 3 weeks
- Infuse 5 mg/kg over 60 minute(s) by intravenous route every 2 weeks
- Infuse 5 mg/kg over 30 minute(s) by intravenous route every 2 weeks
- Infuse 10 mg/kg over 60 minute(s) by intravenous route every 2 weeks
- Infuse 10 mg/kg over 30 minute(s) by intravenous route every 2 weeks
- Infuse 15 mg/kg over 60 minute(s) by intravenous route every 3 weeks
- Infuse 15 mg/kg over 30 minute(s) by intravenous route every 3 weeks
- Infuse 7.5 mg/kg over 90 minute(s) by intravenous route every 3 weeks
- Infuse 7.5 mg/kg over 60 minute(s) by intravenous route every 3 weeks
- Infuse 7.5 mg/kg over 30 minute(s) by intravenous route every 3 weeks
- Infuse 5 mg/kg over 30-90 minute(s) by intravenous route every 2 weeks
- Infuse 10 mg/kg over 30-90 minute(s) by intravenous route every 2 weeks
- Infuse 15 mg/kg over 30-90 minute(s) by intravenous route every 3 weeks
- Infuse 7.5 mg/kg over 30-90 minute(s) by intravenous route every 3 weeks
- natalizumab
- Tysabri
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- sunitinib
- Sutent
- Versacloz
Severe
Moderate
- erlotinib
- Tarceva
- Abnormal vaginal bleeding
- Alveolar hemorrhage
- Gastrointestinal fistula
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Intracerebral hemorrhage
- Lactation
- Necrotizing fasciitis
- Nephrotic syndrome
- New fistula formation involving an internal organ
- Posterior reversible encephalopathy syndrome
- Tracheoesophageal fistula
Contraindicated
- Acute myocardial infarction
- Angina
- Chemotherapy-induced neutropenia
- Chronic heart failure
- Erosive esophagitis
- Female hypogonadism
- Hypertension
- Impaired wound healing
- Invasive surgical procedure
- Neutropenic disorder
- Pregnancy
- Proteinuria
- Surgical wound dehiscence
- Thromboembolic disorder
- Transient cerebral ischemia
Severe
Moderate
- Secondary ovarian failure
ALYMSYS (bevacizumab-maly)
- colon and rectal cancer that has spread to another area
- metastatic renal cell carcinoma
- nonsquamous non-small cell lung cancer
- carcinoma cancer of the cervix
- epithelial cancer of ovary
- glioblastoma multiforme
- Dyspnea
- Exfoliative dermatitis
- Gastrointestinal hemorrhage
- Hyperbilirubinemia
- Hypertension
- Increased alanine transaminase
- Increased aspartate transaminase
- Leukopenia
- Neutropenic disorder
- Proteinuria
- Rectal bleeding
- Secondary ovarian failure
- Stomatitis
- Venous thrombosis
- Abdominal pain with cramps
- Anorexia
- Arthralgia
- Back pain
- Diarrhea
- Dizziness
- Dry skin
- Dysgeusia
- Epistaxis
- Eye tearing
- Fatigue
- General weakness
- Headache disorder
- Myalgia
- Nausea
- Peripheral sensory neuropathy
- Rhinitis
- Upper respiratory infection
- Vomiting
More Frequent
Severe
Less Severe
- Chest pain
- Colitis
- Deep venous thrombosis
- Dehydration
- Gastrointestinal ulcer
- Hypersensitivity drug reaction
- Hypomagnesemia
- Hyponatremia
- Hypotension
- Ileus
- Infection
- Kidney disease with reduction in GFR
- Skin ulcer
- Syncope
- Thrombocytopenic disorder
- Thrombotic disorder
- Alopecia
- Angina
- Constipation
- Dysarthria
- Dyspepsia
- Hemorrhoids
- Hyperhidrosis
- Lymphopenia
- Muscle weakness
- Nasal passage irritation
- Pain
- Pelvic pain
- Rectal pain
- Rhinorrhea
- Voice change
- Weight loss
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal vaginal bleeding
- Acute arterial thromboembolism
- Acute myocardial infarction
- Acute occlusion of mesenteric vein
- Anaphylaxis
- Arterial aneurysm
- Arterial dissection
- Aseptic necrosis of jaw bone
- Bleeding esophageal varices
- Bloody vomit
- Cerebral ischemia
- Cerebrovascular accident
- Chronic heart failure
- Conjunctival hemorrhage
- Dissection of aorta
- Endophthalmitis
- Gastrointestinal fistula
- Gastrointestinal perforation
- Gastrojejunal ulcer
- Hemoptysis
- Hemorrhage
- Hypertensive crisis
- Hypokalemia
- Impaired wound healing
- Intestinal ischemic necrosis
- Intracerebral hemorrhage
- Nasal septal perforation
- Necrotizing fasciitis
- Nephrotic syndrome
- New fistula formation involving an internal organ
- Pancytopenia
- Perforation of gallbladder
- Polyserositis
- Posterior reversible encephalopathy syndrome
- Pulmonary hemorrhage
- Pulmonary hypertension
- Retinal detachment
- Surgical wound dehiscence
- Thrombotic thrombocytopenic purpura
- Tracheoesophageal fistula
- Transient cerebral ischemia
Less Severe
- Blurred vision
- Ocular inflammation
- Vitreous floater
- Wheezing
Contraindicated
None
Severe Precaution
Bevacizumab
Non-mandibular osteonecrosis reported. No antitumor activity observed in relapsed glioblastoma study. No safety and efficacy established.
- 1 Day – 18 Years
- Non-mandibular osteonecrosis reported. No antitumor activity observed in relapsed glioblastoma study. No safety and efficacy established.
Management or Monitoring Precaution
None
Bevacizumab
- Severity Level:
D
- Additional Notes: Insuf human data, animal data sug dev tox;weigh treatment benefit vs fetal risk
Contraindicated
Bevacizumab
Insuff data; mfr recs avoid during breastfeeding and 6 mo after last dose
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insuff data; mfr recs avoid during breastfeeding and 6 mo after last dose |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Bevacizumab
General-Increased risk for severe side effects, including sepsis, deep thrombophlebitis, arterial thromboembolism, hypertension, hypotension, edema, MI, GI hemorrhage.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | Y | Y | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Carcinoma of cervix | |
| C53 | Malignant neoplasm of cervix uteri |
| C53.0 | Malignant neoplasm of endocervix |
| C53.1 | Malignant neoplasm of exocervix |
| C53.8 | Malignant neoplasm of overlapping sites of cervix uteri |
| C53.9 | Malignant neoplasm of cervix uteri, unspecified |
| Epithelial ovarian cancer | |
| C48.1 | Malignant neoplasm of specified parts of peritoneum |
| C48.2 | Malignant neoplasm of peritoneum, unspecified |
| C48.8 | Malignant neoplasm of overlapping sites of retroperitoneum and peritoneum |
| C56 | Malignant neoplasm of ovary |
| C56.1 | Malignant neoplasm of right ovary |
| C56.2 | Malignant neoplasm of left ovary |
| C56.3 | Malignant neoplasm of bilateral ovaries |
| C56.9 | Malignant neoplasm of unspecified ovary |
| C57.01 | Malignant neoplasm of right fallopian tube |
| C57.02 | Malignant neoplasm of left fallopian tube |
| Glioblastoma multiforme | |
| C71 | Malignant neoplasm of brain |
| C71.0 | Malignant neoplasm of cerebrum, except lobes and ventricles |
| C71.1 | Malignant neoplasm of frontal lobe |
| C71.2 | Malignant neoplasm of temporal lobe |
| C71.3 | Malignant neoplasm of parietal lobe |
| C71.4 | Malignant neoplasm of occipital lobe |
| C71.5 | Malignant neoplasm of cerebral ventricle |
| C71.6 | Malignant neoplasm of cerebellum |
| C71.7 | Malignant neoplasm of brain stem |
| C71.8 | Malignant neoplasm of overlapping sites of brain |
| C71.9 | Malignant neoplasm of brain, unspecified |
| Metastatic colorectal cancer | |
| C18 | Malignant neoplasm of colon |
| C18.0 | Malignant neoplasm of cecum |
| C18.1 | Malignant neoplasm of appendix |
| C18.2 | Malignant neoplasm of ascending colon |
| C18.3 | Malignant neoplasm of hepatic flexure |
| C18.4 | Malignant neoplasm of transverse colon |
| C18.5 | Malignant neoplasm of splenic flexure |
| C18.6 | Malignant neoplasm of descending colon |
| C18.7 | Malignant neoplasm of sigmoid colon |
| C18.8 | Malignant neoplasm of overlapping sites of colon |
| C18.9 | Malignant neoplasm of colon, unspecified |
| C19 | Malignant neoplasm of rectosigmoid junction |
| C20 | Malignant neoplasm of rectum |
| C21.8 | Malignant neoplasm of overlapping sites of rectum, anus and anal canal |
| Metastatic renal cell carcinoma | |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| Nonsquamous non-small cell lung cancer | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
| 0-9 | A-Z |
|---|---|
| C18 | Malignant neoplasm of colon |
| C18.0 | Malignant neoplasm of cecum |
| C18.1 | Malignant neoplasm of appendix |
| C18.2 | Malignant neoplasm of ascending colon |
| C18.3 | Malignant neoplasm of hepatic flexure |
| C18.4 | Malignant neoplasm of transverse colon |
| C18.5 | Malignant neoplasm of splenic flexure |
| C18.6 | Malignant neoplasm of descending colon |
| C18.7 | Malignant neoplasm of sigmoid colon |
| C18.8 | Malignant neoplasm of overlapping sites of colon |
| C18.9 | Malignant neoplasm of colon, unspecified |
| C19 | Malignant neoplasm of rectosigmoid junction |
| C20 | Malignant neoplasm of rectum |
| C21.8 | Malignant neoplasm of overlapping sites of rectum, anus and anal canal |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
| C48.1 | Malignant neoplasm of specified parts of peritoneum |
| C48.2 | Malignant neoplasm of peritoneum, unspecified |
| C48.8 | Malignant neoplasm of overlapping sites of retroperitoneum and peritoneum |
| C53 | Malignant neoplasm of cervix uteri |
| C53.0 | Malignant neoplasm of endocervix |
| C53.1 | Malignant neoplasm of exocervix |
| C53.8 | Malignant neoplasm of overlapping sites of cervix uteri |
| C53.9 | Malignant neoplasm of cervix uteri, unspecified |
| C56 | Malignant neoplasm of ovary |
| C56.1 | Malignant neoplasm of right ovary |
| C56.2 | Malignant neoplasm of left ovary |
| C56.3 | Malignant neoplasm of bilateral ovaries |
| C56.9 | Malignant neoplasm of unspecified ovary |
| C57.01 | Malignant neoplasm of right fallopian tube |
| C57.02 | Malignant neoplasm of left fallopian tube |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| C71 | Malignant neoplasm of brain |
| C71.0 | Malignant neoplasm of cerebrum, except lobes and ventricles |
| C71.1 | Malignant neoplasm of frontal lobe |
| C71.2 | Malignant neoplasm of temporal lobe |
| C71.3 | Malignant neoplasm of parietal lobe |
| C71.4 | Malignant neoplasm of occipital lobe |
| C71.5 | Malignant neoplasm of cerebral ventricle |
| C71.6 | Malignant neoplasm of cerebellum |
| C71.7 | Malignant neoplasm of brain stem |
| C71.8 | Malignant neoplasm of overlapping sites of brain |
| C71.9 | Malignant neoplasm of brain, unspecified |
Formulary Reference Tool