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BLINCYTO (BLINATUMOMAB)
- B-cell acute lymphoblastic leukemia
35 mcg intravenous kit
- Infuse 1.167 mcg/hour via infusion pump by continuous infusion route on days 1-28 of a 28 day treatment cycle (cycles 2 and beyond)
35 mcg intravenous solution
- Infuse 1.167 mcg/hour via infusion pump by continuous infusion route on days 1-28 of a 28 day treatment cycle (cycles 2 and beyond)
35 mcg intravenous kit
- Infuse 1.167 mcg/hour via infusion pump by continuous infusion route on days 1-28 of a 28 day treatment cycle (cycles 2 and beyond)
B-cell acute lymphoblastic leukemia
- Infuse 0.375 mcg/hour via infusion pump by continuous infusion route on days 1 through 7 of a 28 day treatment cycle
- Infuse 1.167 mcg/hour via infusion pump by continuous infusion route on days 1 through 28 of a 28 day treatment cycle
- Infuse 0.625 mcg/m2/hour via infusion pump by continuous infusion route on days 8 through 28 of a 28 day treatment cycle (cycle 1)
- Infuse 1.167 mcg/hour via infusion pump by continuous infusion route on days 8 through 28 of a 28 day treatment cycle (cycle 1)
- Infuse 0.208 mcg/m2/hour via infusion pump by continuous infusion route on days 1 through 7 of a 28 day treatment cycle (cycle 1)
- Infuse 0.375 mcg/hour via infusion pump by continuous infusion route on days 1 through 7 of a 28 day treatment cycle (cycle 1)
- Infuse 0.625 mcg/m2/hour via infusion pump by continuous infusion route on days 1-28 of a 28 day treatment cycle (cycles 2 and beyond)
- Infuse 1.167 mcg/hour via infusion pump by continuous infusion route on days 1-28 of a 28 day treatment cycle (cycles 2 and beyond)
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- None
- None
Contraindicated
- Leukoencephalopathy
- Neutropenic disorder
- Pancreatitis
- Pregnancy
- Seizure disorder
- Severe infection
Severe
Moderate
- None
BLINCYTO (BLINATUMOMAB)
- B-cell acute lymphoblastic leukemia
- Anemia
- Fever
- Hypokalemia
- Infection
- Neutropenic disorder
- Peripheral edema
- Skin rash
- Acute abdominal pain
- Constipation
- Headache disorder
- Nausea
- Tremor
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Acute confusion
- Altered consciousness
- Ataxia
- Bacterial sepsis
- Chemotherapy-induced hyperuricemia
- Disseminated intravascular coagulation
- Encephalopathy
- Increased alanine transaminase
- Increased aspartate transaminase
- Opportunistic fungal infection
- Opportunistic viral infection
- Pneumonia
- Seizure disorder
- Thrombocytopenic disorder
- Anorexia
- Aphasia
- Arthralgias
- Back pain
- Chest pain
- Chills
- Cough
- Dizziness
- Dysarthria
- Dyspnea
- Edema
- General weakness
- Hyperbilirubinemia
- Hyperglycemia
- Hypertension
- Hypoalbuminemia
- Hypomagnesemia
- Hypophosphatemia
- Hypotension
- Insomnia
- Leukocytosis
- Leukopenia
- Limb pain
- Lymphopenia
- Memory impairment
- Paresthesia
- Tachycardia
- Vomiting
- Weight gain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute pancreatitis
- Anaphylaxis
- Capillary leak syndrome
- Cytokine release syndrome
- Leukoencephalopathy
- Macrophage activation syndrome
- Suicidal
- Suicidal ideation
Less Severe
- Bone pain
- Depression
- Disturbance of attention
- Flushing
- Hypesthesia
- Lethargy
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Blinatumomab
Increased risk of anemia, thrombocytopenia, hypertension, in pediatrics and hypokalemia in infants.
- 1 Day – 18 Years
- Increased risk of anemia, thrombocytopenia, hypertension, in pediatrics and hypokalemia in infants.
Blinatumomab
- Severity Level:
D
- Additional Notes: Based on the drug's mech of action, b cell depletion is likely to occur in fetus
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Blinatumomab
Insufficient human data avail; manufacturer does not recommend
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data avail; manufacturer does not recommend |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Blinatumomab
General-Elderly may experience a higher incidence of serious infections (e.g. sepsis, pneumonia, opportunisitc infection and catheter site infection). Neuro/Psych-Elderly may experience higher incidence of adverse neurological reactions such as encephalopathy, convulsions, speech disorders, disturbances in consciousness, confusion and disorientation, and coordination and balance disorders. Consider the patient's fall risk.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Blinatumomab may cause certain serious (sometimes fatal) side effects, including cytokine release syndrome-CRS and infusion reactions. Symptoms may include fever, chills, headache, nausea, vomiting, stomach/abdominal pain, trouble breathing, skin rash, weakness, or low blood pressure. Blinatumomab can also cause serious brain, spinal cord, and nerve disorders with symptoms such as headache, trouble sleeping, seizures, confusion, loss of consciousness, difficulty with swallowing/facial movements, or speech and balance problems.<br /><br />Tell your doctor right away if you develop any of these symptoms. You may be given this medication in a hospital or clinic so your doctor can watch for these serious side effects and provide treatment if needed. If you have side effects, your doctor may temporarily stop or slow down your treatment with this medication. Also, your doctor may prescribe other medications before you receive blinatumomab to decrease the risk of side effects.
| B-cell acute lymphoblastic leukemia | |
| C91.0 | Acute lymphoblastic leukemia [ALl] |
| C91.00 | Acute lymphoblastic leukemia not having achieved remission |
| 0-9 | A-Z |
|---|---|
| C91.0 | Acute lymphoblastic leukemia [ALl] |
| C91.00 | Acute lymphoblastic leukemia not having achieved remission |
Formulary Reference Tool