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VIBERZI (eluxadoline)
- Diarrhea predominant irritable bowel syndrome
100 mg tablet
- 1 tablet (100 mg) by oral route 2 times per day
75 mg tablet
- 1 tablet (75 mg) by oral route 2 times per day
Diarrhea predominant irritable bowel syndrome
- 1 tablet (75 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 2 times per day
- None
Contraindicated
- None
Severe
Moderate
- Fanatrex
- gabapentin
- gabapentin enacarbil
- Gralise
- Gralise 30-day Starter Pack
- Horizant
- Neurontin
- Alcoholism
- Biliary obstruction
- Congenital absence of gallbladder
- Gastrointestinal obstruction
- History of cholecystectomy
Contraindicated
- Disease of liver
- Pancreatitis
- Severe constipation
Severe
Moderate
- None
VIBERZI (eluxadoline)
- Diarrhea predominant irritable bowel syndrome
- None
- Acute abdominal pain
- Constipation
- Nausea
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Abdominal distension
- Bronchitis
- Dizziness
- Fatigue
- Flatulence
- Pharyngitis
- Pruritus of skin
- Skin rash
- Upper respiratory infection
- Viral gastroenteritis
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute respiratory insufficiency
- Anaphylaxis
- Angioedema
- Bronchospastic pulmonary disease
- Dyspnea
- Fecal impaction
- Gastrointestinal obstruction
- Intestinal perforation
- Pancreatitis
- Spasm of sphincter of oddi
- Throat constriction
Less Severe
- Asthma
- Chest pain
- Chest tightness
- Drowsy
- Euphoria
- Gastroesophageal reflux disease
- Sedation
- Wheezing
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Eluxadoline
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Eluxadoline
- Severity Level:
2
- Additional Notes: Insufficient human data available, animal data sug no dev tox
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Eluxadoline
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Eluxadoline
General-Geriatrics may experience a higher incidence of severe or gastrointestinal adverse drug reactions.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Diarrhea predominant irritable bowel syndrome | |
| K58.0 | Irritable bowel syndrome with diarrhea |
| 0-9 | A-Z |
|---|---|
| K58.0 | Irritable bowel syndrome with diarrhea |
Formulary Reference Tool