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POLYTRIM (POLYMYXIN B SULFATE/TRIMETHOPRIM)
- Bacterial eye infection
- Bacterial conjunctivitis
- Blepharoconjunctivitis
- Trimethoprim-polymyxin B Eye Drops
- Polytrim Eye Drops
- Polymyxin B Sulfate-trimethoprim Eye Drops
- By Indication
polymyxin B sulfate 10,000 unit-trimethoprim 1 mg/mL eye drops
- Instill 1 drop into affected eye(s) by ophthalmic route every 6 hours
10,000 unit-1 mg/mL eye drops
- Instill 1 drop into affected eye(s) by ophthalmic route every 6 hours
polymyxin B sulfate 10,000 unit-trimethoprim 1 mg/mL eye drops
- Instill 1 drop into affected eye(s) by ophthalmic route every 6 hours
Bacterial conjunctivitis
- Instill 2 drops into left eye by ophthalmic route every 4 hours
- Instill 2 drops into left eye by ophthalmic route every 6 hours
- Instill 2 drops into right eye by ophthalmic route every 4 hours
- Instill 2 drops into right eye by ophthalmic route every 6 hours
- Instill 2 drops into both eyes by ophthalmic route every 4 hours
- Instill 2 drops into both eyes by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 4-6 hours
- Instill 2 drops into right eye by ophthalmic route every 4-6 hours
- Instill 1 drop into left eye by ophthalmic route every 4-6 hours
- Instill 2 drops into left eye by ophthalmic route every 4-6 hours
- Instill 1 drop into both eyes by ophthalmic route every 4-6 hours
- Instill 2 drops into both eyes by ophthalmic route every 4-6 hours
- Instill 1 drop into left eye by ophthalmic route every 4 hours
- Instill 1 drop into left eye by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 4 hours
- Instill 1 drop into right eye by ophthalmic route every 6 hours
- Instill 1 drop into both eyes by ophthalmic route every 4 hours
- Instill 1 drop into both eyes by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 3 hours :Not to exceed 6 doses per day
- Instill 1 drop into left eye by ophthalmic route every 3 hours :Not to exceed 6 doses per day
- Instill 1 drop into both eyes by ophthalmic route every 3 hours :Not to exceed 6 doses per day
- Instill 1 drop into affected eye(s) by ophthalmic route every 4 hours
- Instill 1 drop into affected eye(s) by ophthalmic route every 6 hours
- Instill 2 drops into affected eye(s) by ophthalmic route every 4 hours
- Instill 2 drops into affected eye(s) by ophthalmic route every 6 hours
- Instill 1 drop into affected eye(s) by ophthalmic route every 4-6 hours
- Instill 2 drops into affected eye(s) by ophthalmic route every 4-6 hours
- Instill 1 drop into affected eye(s) by ophthalmic route every 3 hours:Not to exceed 6 doses per day
Bacterial eye infection
- Instill 2 drops into left eye by ophthalmic route every 4 hours
- Instill 2 drops into left eye by ophthalmic route every 6 hours
- Instill 2 drops into right eye by ophthalmic route every 4 hours
- Instill 2 drops into right eye by ophthalmic route every 6 hours
- Instill 2 drops into both eyes by ophthalmic route every 4 hours
- Instill 2 drops into both eyes by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 4-6 hours
- Instill 2 drops into right eye by ophthalmic route every 4-6 hours
- Instill 1 drop into left eye by ophthalmic route every 4-6 hours
- Instill 2 drops into left eye by ophthalmic route every 4-6 hours
- Instill 1 drop into both eyes by ophthalmic route every 4-6 hours
- Instill 2 drops into both eyes by ophthalmic route every 4-6 hours
- Instill 1 drop into left eye by ophthalmic route every 4 hours
- Instill 1 drop into left eye by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 4 hours
- Instill 1 drop into right eye by ophthalmic route every 6 hours
- Instill 1 drop into both eyes by ophthalmic route every 4 hours
- Instill 1 drop into both eyes by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 3 hours :Not to exceed 6 doses per day
- Instill 1 drop into left eye by ophthalmic route every 3 hours :Not to exceed 6 doses per day
- Instill 1 drop into both eyes by ophthalmic route every 3 hours :Not to exceed 6 doses per day
- Instill 1 drop into affected eye(s) by ophthalmic route every 4 hours
- Instill 1 drop into affected eye(s) by ophthalmic route every 6 hours
- Instill 2 drops into affected eye(s) by ophthalmic route every 4 hours
- Instill 2 drops into affected eye(s) by ophthalmic route every 6 hours
- Instill 1 drop into affected eye(s) by ophthalmic route every 4-6 hours
- Instill 2 drops into affected eye(s) by ophthalmic route every 4-6 hours
- Instill 1 drop into affected eye(s) by ophthalmic route every 3 hours:Not to exceed 6 doses per day
Blepharoconjunctivitis
- Instill 2 drops into left eye by ophthalmic route every 4 hours
- Instill 2 drops into left eye by ophthalmic route every 6 hours
- Instill 2 drops into right eye by ophthalmic route every 4 hours
- Instill 2 drops into right eye by ophthalmic route every 6 hours
- Instill 2 drops into both eyes by ophthalmic route every 4 hours
- Instill 2 drops into both eyes by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 4-6 hours
- Instill 2 drops into right eye by ophthalmic route every 4-6 hours
- Instill 1 drop into left eye by ophthalmic route every 4-6 hours
- Instill 2 drops into left eye by ophthalmic route every 4-6 hours
- Instill 1 drop into both eyes by ophthalmic route every 4-6 hours
- Instill 2 drops into both eyes by ophthalmic route every 4-6 hours
- Instill 1 drop into left eye by ophthalmic route every 4 hours
- Instill 1 drop into left eye by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 4 hours
- Instill 1 drop into right eye by ophthalmic route every 6 hours
- Instill 1 drop into both eyes by ophthalmic route every 4 hours
- Instill 1 drop into both eyes by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 3 hours :Not to exceed 6 doses per day
- Instill 1 drop into left eye by ophthalmic route every 3 hours :Not to exceed 6 doses per day
- Instill 1 drop into both eyes by ophthalmic route every 3 hours :Not to exceed 6 doses per day
- Instill 1 drop into affected eye(s) by ophthalmic route every 4 hours
- Instill 1 drop into affected eye(s) by ophthalmic route every 6 hours
- Instill 2 drops into affected eye(s) by ophthalmic route every 4 hours
- Instill 2 drops into affected eye(s) by ophthalmic route every 6 hours
- Instill 1 drop into affected eye(s) by ophthalmic route every 4-6 hours
- Instill 2 drops into affected eye(s) by ophthalmic route every 4-6 hours
- Instill 1 drop into affected eye(s) by ophthalmic route every 3 hours:Not to exceed 6 doses per day
- None
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- None
Severe
Moderate
- No disease contraindications
POLYTRIM (POLYMYXIN B SULFATE/TRIMETHOPRIM)
- Bacterial eye infection
- Bacterial conjunctivitis
- Blepharoconjunctivitis
- Ocular inflammation
- Ocular itching
- Ocular redness
- None
More Frequent
Severe
Less Severe
- Ocular irritation
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- None
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Polymyxin B Sulfate (ophth,otic,top)
- Severity Level:
B
- Additional Notes:
Trimethoprim (ophth)
- Severity Level:
C
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Polymyxin B
None
Minimal syst absorption;No reported adverse effects on 50 infants w/oral drug
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | None |
Trimethoprim (ophth)
None
Minimal syst absorption;No reported adverse effects on 50 infants w/oral drug
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Minimal syst absorption;No reported adverse effects on 50 infants w/oral drug |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Bacterial conjunctivitis | |
| H10.02 | Other mucopurulent conjunctivitis |
| H10.021 | Other mucopurulent conjunctivitis, right eye |
| H10.022 | Other mucopurulent conjunctivitis, left eye |
| H10.023 | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | Other mucopurulent conjunctivitis, unspecified eye |
| H10.3 | Unspecified acute conjunctivitis |
| H10.30 | Unspecified acute conjunctivitis, unspecified eye |
| H10.31 | Unspecified acute conjunctivitis, right eye |
| H10.32 | Unspecified acute conjunctivitis, left eye |
| H10.33 | Unspecified acute conjunctivitis, bilateral |
| Bacterial eye infection | |
| H10.0 | Mucopurulent conjunctivitis |
| H10.01 | Acute follicular conjunctivitis |
| H10.011 | Acute follicular conjunctivitis, right eye |
| H10.012 | Acute follicular conjunctivitis, left eye |
| H10.013 | Acute follicular conjunctivitis, bilateral |
| H10.019 | Acute follicular conjunctivitis, unspecified eye |
| H10.02 | Other mucopurulent conjunctivitis |
| H10.021 | Other mucopurulent conjunctivitis, right eye |
| H10.022 | Other mucopurulent conjunctivitis, left eye |
| H10.023 | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | Other mucopurulent conjunctivitis, unspecified eye |
| H10.9 | Unspecified conjunctivitis |
| Blepharoconjunctivitis | |
| H10.5 | Blepharoconjunctivitis |
| H10.50 | Unspecified blepharoconjunctivitis |
| H10.501 | Unspecified blepharoconjunctivitis, right eye |
| H10.502 | Unspecified blepharoconjunctivitis, left eye |
| H10.503 | Unspecified blepharoconjunctivitis, bilateral |
| H10.509 | Unspecified blepharoconjunctivitis, unspecified eye |
| H10.52 | Angular blepharoconjunctivitis |
| H10.521 | Angular blepharoconjunctivitis, right eye |
| H10.522 | Angular blepharoconjunctivitis, left eye |
| H10.523 | Angular blepharoconjunctivitis, bilateral |
| H10.529 | Angular blepharoconjunctivitis, unspecified eye |
| 0-9 | A-Z |
|---|---|
| H10.0 | Mucopurulent conjunctivitis |
| H10.01 | Acute follicular conjunctivitis |
| H10.011 | Acute follicular conjunctivitis, right eye |
| H10.012 | Acute follicular conjunctivitis, left eye |
| H10.013 | Acute follicular conjunctivitis, bilateral |
| H10.019 | Acute follicular conjunctivitis, unspecified eye |
| H10.02 | Other mucopurulent conjunctivitis |
| H10.02 | Other mucopurulent conjunctivitis |
| H10.021 | Other mucopurulent conjunctivitis, right eye |
| H10.021 | Other mucopurulent conjunctivitis, right eye |
| H10.022 | Other mucopurulent conjunctivitis, left eye |
| H10.022 | Other mucopurulent conjunctivitis, left eye |
| H10.023 | Other mucopurulent conjunctivitis, bilateral |
| H10.023 | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | Other mucopurulent conjunctivitis, unspecified eye |
| H10.029 | Other mucopurulent conjunctivitis, unspecified eye |
| H10.3 | Unspecified acute conjunctivitis |
| H10.30 | Unspecified acute conjunctivitis, unspecified eye |
| H10.31 | Unspecified acute conjunctivitis, right eye |
| H10.32 | Unspecified acute conjunctivitis, left eye |
| H10.33 | Unspecified acute conjunctivitis, bilateral |
| H10.5 | Blepharoconjunctivitis |
| H10.50 | Unspecified blepharoconjunctivitis |
| H10.501 | Unspecified blepharoconjunctivitis, right eye |
| H10.502 | Unspecified blepharoconjunctivitis, left eye |
| H10.503 | Unspecified blepharoconjunctivitis, bilateral |
| H10.509 | Unspecified blepharoconjunctivitis, unspecified eye |
| H10.52 | Angular blepharoconjunctivitis |
| H10.521 | Angular blepharoconjunctivitis, right eye |
| H10.522 | Angular blepharoconjunctivitis, left eye |
| H10.523 | Angular blepharoconjunctivitis, bilateral |
| H10.529 | Angular blepharoconjunctivitis, unspecified eye |
| H10.9 | Unspecified conjunctivitis |
Formulary Reference Tool