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VALACYCLOVIR (VALACYCLOVIR HCL)
- Chickenpox
- Genital herpes simplex
- Herpes labialis
- Herpes zoster
- Recurrent herpes genitalis
- Suppression of recurrent herpes simplex infection
- Suppression of recurrent herpes simplex infection in HIV
1 gram tablet
- 1 tablet (1,000 mg) by oral route every 12 hours
500 mg tablet
- 1 tablet (500 mg) by oral route once daily
1 gram tablet
- 1 tablet (1,000 mg) by oral route every 12 hours
500 mg tablet
- 1 tablet (500 mg) by oral route once daily
Genital herpes simplex
- 2 tablets (1,000 mg) by oral route 2 times per day
- 2 tablets (1,000 mg) by oral route every 12 hours
- 1 tablet (1,000 mg) by oral route 2 times per day
- 1 tablet (1,000 mg) by oral route 2 times per day for 10 days
- 1 tablet (1,000 mg) by oral route every 12 hours
- 1 tablet (1,000 mg) by oral route every 12 hours for 10 days
- 2 tablets (1,000 mg) by oral route 2 times per day for 10 days
- 2 tablets (1,000 mg) by oral route every 12 hours for 10 days
Herpes zoster
- 2 tablets (1,000 mg) by oral route 3 times per day
- 1 tablet (1,000 mg) by oral route 3 times per day
- 1 tablet (1,000 mg) by oral route 3 times per day for 7 days
- 1 tablet (1,000 mg) by oral route every 8 hours
- 1 tablet (1,000 mg) by oral route every 8 hours for 7 days
- 2 tablets (1,000 mg) by oral route 3 times per day for 7 days
- 2 tablets (1,000 mg) by oral route every 8 hours
- 2 tablets (1,000 mg) by oral route every 8 hours for 7 days
Recurrent herpes genitalis
- 1 tablet (500 mg) by oral route 2 times per day
- 1 tablet (500 mg) by oral route 2 times per day for 3 days
- 1 tablet (500 mg) by oral route every 12 hours for 3 days
- 1 tablet (500 mg) by oral route every 12 hours
Suppression of recurrent herpes simplex infection
- 2 tablets (1,000 mg) by oral route once daily
- 1 tablet (1,000 mg) by oral route once daily
- 1 tablet (500 mg) by oral route once daily
- measles,mumps,rub,varicel(PF)
- Proquad (pf)
- varicella virus vacc live (PF)
- Varivax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- tizanidine
- Zanaflex
Severe
Moderate
- Atripla
- Complera
- efavirenz-emtricitabin-tenofov
- elvitegr-cobicist-emtric-tenof
- emtricitab-rilpivirine-tenofov
- emtricitabine-tenofovir
- Stribild
- tenofovir disoproxil fumarate
- Truvada
- Viread
- Hemolytic uremic syndrome
- Thrombotic thrombocytopenic purpura
Contraindicated
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Dehydration
Severe
Moderate
- Kidney disease with likely reduction in GFR
VALACYCLOVIR (VALACYCLOVIR HCL)
- Chickenpox
- Genital herpes simplex
- Herpes labialis
- Herpes zoster
- Recurrent herpes genitalis
- Suppression of recurrent herpes simplex infection
- Suppression of recurrent herpes simplex infection in HIV
- None
- Headache disorder
- Nausea
More Frequent
Severe
Less Severe
- Dysmenorrhea
- Abdominal pain with cramps
- Anorexia
- Arthralgias
- Constipation
- Diarrhea
- Disorder of the digestive system
- Dizziness
- Fatigue
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Angioedema
- Coma
- Dyspnea
- Encephalopathy
- Erythema multiforme
- Hypertension
- Neutropenic disorder
- Renal failure
- Seizure disorder
- Thrombocytopenic disorder
- Urticaria
Less Severe
- Acute confusion
- Aggressive behavior
- Agitation
- Ataxia
- Hallucinations
- Manic disorder
- Skin photosensitivity
- Skin rash
- Tachycardia
- Tremor
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Valacyclovir
Safety & efficacy not established age < 2 years.
- 1 Day – 2 Years
- Safety & efficacy not established age < 2 years.
Valacyclovir
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Valacyclovir
Limited data suggest low levels excreted resulting in no adverse effects
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest low levels excreted resulting in no adverse effects |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Valacyclovir
Renal-Dose reduction for CLCr<50mL/min. Higher rates of CNS adverse events.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Chickenpox | |
| B01 | Varicella [chickenpox] |
| B01.9 | Varicella without complication |
| Genital herpes simplex | |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.01 | Herpesviral infection of penis |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.03 | Herpesviral cervicitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.9 | Anogenital herpesviral infection, unspecified |
| Herpes labialis | |
| B00.1 | Herpesviral vesicular dermatitis |
| Herpes zoster | |
| B02 | Zoster [herpes zoster] |
| B02.0 | Zoster encephalitis |
| B02.1 | Zoster meningitis |
| B02.3 | Zoster ocular disease |
| B02.30 | Zoster ocular disease, unspecified |
| B02.31 | Zoster conjunctivitis |
| B02.32 | Zoster iridocyclitis |
| B02.33 | Zoster keratitis |
| B02.34 | Zoster scleritis |
| B02.39 | Other herpes zoster eye disease |
| B02.7 | Disseminated zoster |
| B02.8 | Zoster with other complications |
| B02.9 | Zoster without complications |
| Recurrent herpes genitalis | |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.01 | Herpesviral infection of penis |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.03 | Herpesviral cervicitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.9 | Anogenital herpesviral infection, unspecified |
| Suppression of recurrent herpes simplex infection | |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.01 | Herpesviral infection of penis |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.03 | Herpesviral cervicitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.1 | Herpesviral infection of perianal skin and rectum |
| A60.9 | Anogenital herpesviral infection, unspecified |
| B00.2 | Herpesviral gingivostomatitis and pharyngotonsillitis |
| B00.89 | Other herpesviral infection |
| B00.9 | Herpesviral infection, unspecified |
| Suppression of recurrent herpes simplex infection in HIV | |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.01 | Herpesviral infection of penis |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.03 | Herpesviral cervicitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.1 | Herpesviral infection of perianal skin and rectum |
| A60.9 | Anogenital herpesviral infection, unspecified |
| B00.0 | Eczema herpeticum |
| B00.1 | Herpesviral vesicular dermatitis |
| B00.2 | Herpesviral gingivostomatitis and pharyngotonsillitis |
| B00.5 | Herpesviral ocular disease |
| B00.50 | Herpesviral ocular disease, unspecified |
| B00.51 | Herpesviral iridocyclitis |
| B00.52 | Herpesviral keratitis |
| B00.53 | Herpesviral conjunctivitis |
| B00.59 | Other herpesviral disease of eye |
| B00.89 | Other herpesviral infection |
| 0-9 | A-Z |
|---|---|
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60 | Anogenital herpesviral [herpes simplex] infections |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.0 | Herpesviral infection of genitalia and urogenital tract |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.00 | Herpesviral infection of urogenital system, unspecified |
| A60.01 | Herpesviral infection of penis |
| A60.01 | Herpesviral infection of penis |
| A60.01 | Herpesviral infection of penis |
| A60.01 | Herpesviral infection of penis |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.02 | Herpesviral infection of other male genital organs |
| A60.03 | Herpesviral cervicitis |
| A60.03 | Herpesviral cervicitis |
| A60.03 | Herpesviral cervicitis |
| A60.03 | Herpesviral cervicitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.04 | Herpesviral vulvovaginitis |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.09 | Herpesviral infection of other urogenital tract |
| A60.1 | Herpesviral infection of perianal skin and rectum |
| A60.1 | Herpesviral infection of perianal skin and rectum |
| A60.9 | Anogenital herpesviral infection, unspecified |
| A60.9 | Anogenital herpesviral infection, unspecified |
| A60.9 | Anogenital herpesviral infection, unspecified |
| A60.9 | Anogenital herpesviral infection, unspecified |
| B00.0 | Eczema herpeticum |
| B00.1 | Herpesviral vesicular dermatitis |
| B00.1 | Herpesviral vesicular dermatitis |
| B00.2 | Herpesviral gingivostomatitis and pharyngotonsillitis |
| B00.2 | Herpesviral gingivostomatitis and pharyngotonsillitis |
| B00.5 | Herpesviral ocular disease |
| B00.50 | Herpesviral ocular disease, unspecified |
| B00.51 | Herpesviral iridocyclitis |
| B00.52 | Herpesviral keratitis |
| B00.53 | Herpesviral conjunctivitis |
| B00.59 | Other herpesviral disease of eye |
| B00.89 | Other herpesviral infection |
| B00.89 | Other herpesviral infection |
| B00.9 | Herpesviral infection, unspecified |
| B01 | Varicella [chickenpox] |
| B01.9 | Varicella without complication |
| B02 | Zoster [herpes zoster] |
| B02.0 | Zoster encephalitis |
| B02.1 | Zoster meningitis |
| B02.3 | Zoster ocular disease |
| B02.30 | Zoster ocular disease, unspecified |
| B02.31 | Zoster conjunctivitis |
| B02.32 | Zoster iridocyclitis |
| B02.33 | Zoster keratitis |
| B02.34 | Zoster scleritis |
| B02.39 | Other herpes zoster eye disease |
| B02.7 | Disseminated zoster |
| B02.8 | Zoster with other complications |
| B02.9 | Zoster without complications |
Formulary Reference Tool