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VRAYLAR (CARIPRAZINE HYDROCHLORIDE)
- Mania associated with bipolar disorder
- Mixed bipolar I disorder
- Schizophrenia
- Depression associated with bipolar disorder
1.5 mg (1)-3 mg (6) capsules in a dose pack
- Dosage information is not available
1.5 mg capsule
- 1 capsule (1.5 mg) by oral route once daily
3 mg capsule
- 1 capsule (3 mg) by oral route once daily
4.5 mg capsule
- 1 capsule (4.5 mg) by oral route once daily
6 mg capsule
- 1 capsule (6 mg) by oral route once daily
Depression associated with bipolar disorder
- 2 capsules (3 mg) by oral route once daily
- 1 capsule (3 mg) by oral route once daily
- 1 capsule (1.5 mg) by oral route once daily
Mania associated with bipolar disorder
- 2 capsules (3 mg) by oral route once daily
- 1 capsule (3 mg) by oral route once daily
- 2 capsules (6 mg) by oral route once daily
- 1 capsule (6 mg) by oral route once daily
- 1 capsule (4.5 mg) by oral route once daily
Mixed bipolar I disorder
- 2 capsules (3 mg) by oral route once daily
- 1 capsule (3 mg) by oral route once daily
- 2 capsules (6 mg) by oral route once daily
- 1 capsule (6 mg) by oral route once daily
- 1 capsule (4.5 mg) by oral route once daily
Schizophrenia
- 2 capsules (3 mg) by oral route once daily
- 1 capsule (3 mg) by oral route once daily
- 2 capsules (6 mg) by oral route once daily
- 1 capsule (6 mg) by oral route once daily
- 1 capsule (1.5 mg) by oral route once daily
- 1 capsule (4.5 mg) by oral route once daily
- None
Contraindicated
- None
Severe
Moderate
- Aplenzin
- Apokyn
- apomorphine
- Buproban
- bupropion HBr
- bupropion HCl
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Comtan
- entacapone
- Forfivo Xl
- Mirapex
- Mirapex Er
- pramipexole
- Requip
- Requip Xl
- ropinirole
- Sinemet
- Sinemet Cr
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Zyban
- Neuroleptic malignant syndrome
Contraindicated
- Acute myocardial infarction
- Chronic heart failure
- Dehydration
- Dysphagia
- Hyperglycemia
- Hyperlipidemia
- Hypotension
- Leukopenia
- Lower seizure threshold
- Neutropenic disorder
- Orthostatic hypotension
- Predisposition to aspiration
- Pregnancy
- Seizure disorder
- Senile dementia
- Suicidal ideation
- Tardive dyskinesia
Severe
Moderate
- Obesity
- Weight gain
VRAYLAR (CARIPRAZINE HYDROCHLORIDE)
- Mania associated with bipolar disorder
- Mixed bipolar I disorder
- Schizophrenia
- Depression associated with bipolar disorder
- Akathisia
- Extrapyramidal disease
- Drowsy
- Dyspepsia
- Headache disorder
- Nausea
- Nervousness
- Syncope
- Weight gain
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Hypertension
- Leukopenia
- Neutropenic disorder
- Orthostatic hypotension
- Seizure disorder
- Acute abdominal pain
- Agitation
- Anorexia
- Arthralgias
- Back pain
- Blurred vision
- Constipation
- Cough
- Diarrhea
- Dizziness
- Dysphagia
- Fatigue
- Hyperglycemia
- Hyperlipidemia
- Hypersomnia
- Insomnia
- Pain
- Pharyngitis
- Sedation
- Symptoms of anxiety
- Tachycardia
- Toothache
- Upper abdominal pain
- Urinary tract infection
- Vomiting
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Accidental fall
- Angioedema
- Cerebrovascular accident
- Diabetes mellitus
- Esophageal dysmotility
- Fever
- Gastritis
- Gastroesophageal reflux disease
- Hepatitis
- Hyponatremia
- Rhabdomyolysis
- Stevens-johnson syndrome
- Suicidal
- Suicidal ideation
- Tardive dyskinesia
Less Severe
- Hyperhidrosis
- Pruritus of skin
- Skin rash
- Urticaria
Contraindicated
None
Severe Precaution
Cariprazine
Possible increased risk of suicidal ideation and suicide attempts. Safety and efficacy not established in pediatrics. Not approved for pediatric use.
- 1 Day – 18 Years
- Possible increased risk of suicidal ideation and suicide attempts. Safety and efficacy not established in pediatrics. Not approved for pediatric use.
Management or Monitoring Precaution
None
Cariprazine
- Severity Level:
D
- Additional Notes: Non-teratogenic complications (resp, gi,cns) with exposure during 3rd trimester
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Cariprazine
Insuff human data;Weigh maternal treatment benefit vs. possible infant risk
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insuff human data;Weigh maternal treatment benefit vs. possible infant risk |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Cariprazine
Neuro/Psych-Inc risk of tardive dyskinesia. CNS effects; sedation, cognit impair, and inc fall risk. Avoid use for behav probs of dementia or delirium unless failed nonpharm options. Inc risk of stroke, cognit decline, and death when used w/senile dementia. Not approved for treatment of dementia-related psychosis. Endocrine-May exacerbate or cause SIADH or hyponatremia. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen constipation.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.
| Depression associated with bipolar disorder | |
| F31.3 | Bipolar disorder, current episode depressed, mild or moderate severity |
| F31.30 | Bipolar disorder, current episode depressed, mild or moderate severity, unspecified |
| F31.31 | Bipolar disorder, current episode depressed, mild |
| F31.32 | Bipolar disorder, current episode depressed, moderate |
| F31.4 | Bipolar disorder, current episode depressed, severe, without psychotic features |
| F31.5 | Bipolar disorder, current episode depressed, severe, with psychotic features |
| Mania associated with bipolar disorder | |
| F31.1 | Bipolar disorder, current episode manic without psychotic features |
| F31.10 | Bipolar disorder, current episode manic without psychotic features, unspecified |
| F31.11 | Bipolar disorder, current episode manic without psychotic features, mild |
| F31.12 | Bipolar disorder, current episode manic without psychotic features, moderate |
| F31.13 | Bipolar disorder, current episode manic without psychotic features, severe |
| F31.2 | Bipolar disorder, current episode manic severe with psychotic features |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| Mixed bipolar I disorder | |
| F31.6 | Bipolar disorder, current episode mixed |
| F31.60 | Bipolar disorder, current episode mixed, unspecified |
| F31.61 | Bipolar disorder, current episode mixed, mild |
| F31.62 | Bipolar disorder, current episode mixed, moderate |
| F31.63 | Bipolar disorder, current episode mixed, severe, without psychotic features |
| F31.64 | Bipolar disorder, current episode mixed, severe, with psychotic features |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| Schizophrenia | |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| 0-9 | A-Z |
|---|---|
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| F31.1 | Bipolar disorder, current episode manic without psychotic features |
| F31.10 | Bipolar disorder, current episode manic without psychotic features, unspecified |
| F31.11 | Bipolar disorder, current episode manic without psychotic features, mild |
| F31.12 | Bipolar disorder, current episode manic without psychotic features, moderate |
| F31.13 | Bipolar disorder, current episode manic without psychotic features, severe |
| F31.2 | Bipolar disorder, current episode manic severe with psychotic features |
| F31.3 | Bipolar disorder, current episode depressed, mild or moderate severity |
| F31.30 | Bipolar disorder, current episode depressed, mild or moderate severity, unspecified |
| F31.31 | Bipolar disorder, current episode depressed, mild |
| F31.32 | Bipolar disorder, current episode depressed, moderate |
| F31.4 | Bipolar disorder, current episode depressed, severe, without psychotic features |
| F31.5 | Bipolar disorder, current episode depressed, severe, with psychotic features |
| F31.6 | Bipolar disorder, current episode mixed |
| F31.60 | Bipolar disorder, current episode mixed, unspecified |
| F31.61 | Bipolar disorder, current episode mixed, mild |
| F31.62 | Bipolar disorder, current episode mixed, moderate |
| F31.63 | Bipolar disorder, current episode mixed, severe, without psychotic features |
| F31.64 | Bipolar disorder, current episode mixed, severe, with psychotic features |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
Formulary Reference Tool