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FEMHRT (NORETHINDRONE ACETATE-ETHINYL ESTRADIOL)
- Post-menopausal osteoporosis prevention
- Vasomotor symptoms associated with menopause
0.5 mg-2.5 mcg tablet
- 1 tablet by oral route once daily
Low Dose 0.5 mg-2.5 mcg tablet
- 1 tablet by oral route once daily
Post-menopausal osteoporosis prevention
- 1 tablet by oral route once daily
Vasomotor symptoms associated with menopause
- 1 tablet by oral route once daily
- anastrozole
- Arimidex
- Aromasin
- Cyklokapron
- exemestane
- Femara
- letrozole
- Lysteda
- tranexamic acid
Contraindicated
- None
Severe
Moderate
- A-hydrocort
- A-methapred
- Alagesic Lq
- amobarbital
- Amytal
- Anucort-hc
- Anusol-hc
- Aristospan Intra-articular
- Aristospan Intralesional
- Ascomp With Codeine
- Belladonna-phenobarbital
- betamethasone acet & sod phos
- Bivigam
- Brevital
- budesonide
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- Capacet
- Carimune Nf Nanofiltered
- Celestone Soluspan
- Cerebyx
- codeine-butalbital-ASA-caff
- Colocort
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Depo-medrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- Entocort Ec
- Esgic
- ethotoin
- Evista
- Ez Use Joint-tunnel-trigger
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- First-duke's
- First-mary's Mouthwash
- Flebogamma Dif
- Flo-pred
- fludrocortisone
- fosphenytoin
- Gamastan S/d
- Gammagard Liquid
- Gammagard S-d (iga < 1 Mcg/ml)
- Gammagard S/d
- Gammaked
- Gammaplex
- Gamunex-c
- Grx Hicort 25
- Hemril-30
- Hizentra
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- immune glob(IgG)(hum)-maltose
- immune globulin (human) (IgG)
- immune globulin(hum),capr(IgG)
- Kenalog
- Luminal
- Margesic
- Marten-tab
- Medrol
- Medrol (pak)
- methohexital
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Millipred
- Millipred Dp
- Mysoline
- Nembutal Sodium
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Octagam
- Orapred
- Orapred Odt
- Pediapred
- Peganone
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Physicians Ez Use M-pred
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- primidone
- Privigen
- Proctocort
- raloxifene
- Rayos
- Rectacort-hc
- secobarbital sodium
- Seconal Sodium
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Tencon
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- Uceris
- Veripred 20
- Zebutal
- Acute myocardial infarction
- Antithrombin III deficiency
- Carcinoma of breast
- Cerebrovascular accident
- Deep venous thrombosis
- Disease of liver
- Estrogen-dependent neoplasm
- Porphyria
- Predisposition to thrombosis
- Pregnancy
- Protein C deficiency disease
- Pulmonary thromboembolism
- Thromboembolic disorder
- Thrombophilia
Contraindicated
- Acute myocardial infarction
- Bed-ridden
- Cerebrovascular accident
- Coronary artery disease
- Deep venous thrombosis
- Dementia
- Edema
- Endometrial carcinoma
- Family history of malignant tumor of breast
- Hereditary angioedema
- Hypercalcemia
- Increased cardiovascular event risk
- Invasive surgical procedure
- Malignant neoplasm of the ovary
- Obesity
- Papilledema
- Predisposition to thrombosis
- Pulmonary thromboembolism
- Retinal thrombosis
- Systemic lupus erythematosus
- Thromboembolic disorder
- Thrombophlebitis
- Tobacco smoker
Severe
Moderate
- Asthma
- Chronic heart failure
- Depression
- Diabetes mellitus
- Edema
- Gallbladder disease
- Hepatic porphyria
- Hyperlipidemia
- Hypertension
- Hypertriglyceridemia
- Hypoparathyroidism
- Hypothyroidism
- Kidney disease with reduction in GFR
- Migraine
- Seizure disorder
- Systemic lupus erythematosus
- Unspecified lump in breast
- Uterine leiomyoma
FEMHRT (NORETHINDRONE ACETATE-ETHINYL ESTRADIOL)
- Post-menopausal osteoporosis prevention
- Vasomotor symptoms associated with menopause
- Abdominal distension
- Abnormal vaginal bleeding
- Irregular menstrual periods
- Abdominal distension
- Abdominal pain with cramps
- Anorexia
- Appetite changes
- Breast milk flow decreased
- Dysmenorrhea
- Edema
- Fatigue
- Gynecomastia
- Headache disorder
- Mastalgia
- Myalgias
- Nausea
- Peripheral edema
- Sinusitis
- Vaginitis
- Vulvovaginal candidiasis
- Weight gain
- Weight loss
More Frequent
Severe
Less Severe
- Endometrial hyperplasia
- Gastroenteritis
- Bronchitis
- Diarrhea
- Dizziness
- Dyspepsia
- Headache disorder
- Hypertonia
- Irritability
- Libido changes
- Migraine
- Mood changes
- Vaginal discharge
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute myocardial infarction
- Anaphylaxis
- Angioedema
- Back pain
- Cerebrovascular accident
- Change in corneal curvature
- Chest pain
- Cystitis
- Depression
- Ectopic pregnancy
- Endometrial carcinoma
- Erythema multiforme
- Erythema nodosum
- Galactorrhea not associated with childbirth
- Gallbladder obstruction
- Hepatitis
- Hypersensitivity drug reaction
- Hypertension
- Influenza
- Involuntary muscle movement
- Malignant neoplasm of the ovary
- Menorrhagia
- Neoplasm of breast
- Obstructive hyperbilirubinemia
- Optic neuritis
- Ovarian cyst
- Pancreatitis
- Pruritus of skin
- Pulmonary thromboembolism
- Retinal thrombosis
- Skin rash
- Thromboembolic disorder
- Thrombophlebitis
- Thrombotic disorder
- Unspecified lump in breast
- Urticaria
Less Severe
- Abnormal vaginal bleeding
- Acne vulgaris
- Alopecia
- Amenorrhea
- Back pain
- Body fluid retention
- Cervical discharge
- Chest pain
- Chloasma
- Constipation
- Drowsy
- Erosion of cervix
- Fever
- Hirsutism
- Hyperglycemia
- Insomnia
- Limb pain
- Mastalgia
- Menorrhagia
- Migraine
- Nausea
- Nervousness
- Nipple discharge
- Upper respiratory infection
- Urticaria
- Weight gain
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Ethinyl Estradiol (HRT, acne)
Safety and efficacy in children has not been established.
Safety and efficacy pre-menarche has not been established.
- 1 Day – 13 Years
- Safety and efficacy in children has not been established.
Norethindrone
Safety and efficacy in children has not been established.
Safety and efficacy pre-menarche has not been established.
- 1 Day – 13 Years
- Safety and efficacy pre-menarche has not been established.
Ethinyl Estradiol
- Severity Level:
2
- Additional Notes: Not indicated during pregnancy, no known dev tox
Norethindrone
- Severity Level:
X
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Ethinyl Estradiol
May decrease milk production, use lowest dose
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Drug shown to have adverse effect | May decrease milk production, use lowest dose |
No Known Risk
Norethindrone
May inhibit lactation at high doses.
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Excreted | Not known; no or inclusive data | May inhibit lactation at high doses. |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Estrogens, either used alone or with a progestin, have rarely caused very serious side effects. Discuss the risks and benefits of hormone treatment with your doctor. Estrogens and progestins should not be used to prevent heart disease or dementia.<br /><br /> In postmenopausal women, estrogen when used with a progestin can increase the risk of heart disease (such as heart attacks), stroke, serious blood clots in the lungs/legs, dementia, and cancer of the breast/ovaries. The risk for serious side effects may depend on the dose of estrogen and the length of time it is used. Therefore, this medication should be used at the lowest effective dose and for the shortest amount of time.<br /><br />Discuss the use of this medication with your doctor regularly (for example, every 3 to 6 months) to see if you still need to use it. If you will be using this medication long-term, you should have regular complete physical exams (for example, once a year) as directed by your doctor. See also Notes section.
| Post-menopausal osteoporosis prevention | |
| Z78.0 | Asymptomatic menopausal state |
| Vasomotor symptoms associated with menopause | |
| N95.1 | Menopausal and female climacteric states |
| N95.9 | Unspecified menopausal and perimenopausal disorder |
| 0-9 | A-Z |
|---|---|
| N95.1 | Menopausal and female climacteric states |
| N95.9 | Unspecified menopausal and perimenopausal disorder |
| Z78.0 | Asymptomatic menopausal state |
Formulary Reference Tool