ZANAFLEX (TIZANIDINE HCL)
- Muscle spasm
- Muscle spasticity of cerebral origin
- Muscle spasticity of spinal origin
4 mg tablet
- 1 tablet (4 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
2 mg capsule
- 1 capsule (2 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
4 mg capsule
- 1 capsule (4 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
6 mg capsule
- 1 capsule (6 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
2 mg capsule
- 1 capsule (2 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
4 mg capsule
- 1 capsule (4 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
6 mg capsule
- 1 capsule (6 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
tizanidine 2 mg capsule
- 1 capsule (2 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
tizanidine 4 mg capsule
- 1 capsule (4 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
tizanidine 6 mg capsule
- 1 capsule (6 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
Muscle spasm
- 1 capsule (2 mg) by oral route every 8 hours
- 1 capsule (2 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (2 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (2 mg) by oral route every 8 hours as needed
- 1 capsule (2 mg) by oral route once daily
- 1 capsule (2 mg) by oral route once daily at bedtime
- 1 tablet (4 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 1 tablet (4 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 1 tablet (4 mg) by oral route every 8 hours as needed
- 2 capsules (4 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 2 capsules (4 mg) by oral route every 8 hours as needed
- 2 capsules (4 mg) by oral route every 6-8 hours as needed not toexceed 3 doses in 24 hours
- 1 capsule (4 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (4 mg) by oral route every 8 hours as needed
- 1 capsule (4 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (4 mg) by oral route 3 times per day
- 1 capsule (6 mg) by oral route 3 times per day
- 1 capsule (6 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (6 mg) by oral route every 8 hours as needed
- 1 capsule (6 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 2 capsules (8 mg) by oral route 3 times per day
- 2 tablets (8 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 2 tablets (8 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 2 capsules (8 mg) by oral route every 8 hours as needed
- 2 capsules (8 mg) by oral route every 6-8 hours as needed not toexceed 3 doses in 24 hours
- 2 capsules (8 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 2 tablets (8 mg) by oral route every 8 hours as needed
- 2 capsules (12 mg) by oral route 3 times per day
- 2 capsules (12 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 2 capsules (12 mg) by oral route every 8 hours as needed
Muscle spasticity of cerebral origin
- 1 capsule (2 mg) by oral route every 8 hours
- 1 capsule (2 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (2 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (2 mg) by oral route every 8 hours as needed
- 1 capsule (2 mg) by oral route once daily
- 1 capsule (2 mg) by oral route once daily at bedtime
- 1 tablet (4 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 1 tablet (4 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 1 tablet (4 mg) by oral route every 8 hours as needed
- 2 capsules (4 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 2 capsules (4 mg) by oral route every 8 hours as needed
- 2 capsules (4 mg) by oral route every 6-8 hours as needed not toexceed 3 doses in 24 hours
- 1 capsule (4 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (4 mg) by oral route every 8 hours as needed
- 1 capsule (4 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (4 mg) by oral route 3 times per day
- 1 capsule (6 mg) by oral route 3 times per day
- 1 capsule (6 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (6 mg) by oral route every 8 hours as needed
- 1 capsule (6 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 2 capsules (8 mg) by oral route 3 times per day
- 2 tablets (8 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 2 tablets (8 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 2 capsules (8 mg) by oral route every 8 hours as needed
- 2 capsules (8 mg) by oral route every 6-8 hours as needed not toexceed 3 doses in 24 hours
- 2 capsules (8 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 2 tablets (8 mg) by oral route every 8 hours as needed
- 2 capsules (12 mg) by oral route 3 times per day
- 2 capsules (12 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 2 capsules (12 mg) by oral route every 8 hours as needed
Muscle spasticity of spinal origin
- 1 capsule (2 mg) by oral route every 8 hours
- 1 capsule (2 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (2 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (2 mg) by oral route every 8 hours as needed
- 1 capsule (2 mg) by oral route once daily
- 1 capsule (2 mg) by oral route once daily at bedtime
- 1 tablet (4 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 1 tablet (4 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 1 tablet (4 mg) by oral route every 8 hours as needed
- 2 capsules (4 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 2 capsules (4 mg) by oral route every 8 hours as needed
- 2 capsules (4 mg) by oral route every 6-8 hours as needed not toexceed 3 doses in 24 hours
- 1 capsule (4 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (4 mg) by oral route every 8 hours as needed
- 1 capsule (4 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (4 mg) by oral route 3 times per day
- 1 capsule (6 mg) by oral route 3 times per day
- 1 capsule (6 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 1 capsule (6 mg) by oral route every 8 hours as needed
- 1 capsule (6 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 2 capsules (8 mg) by oral route 3 times per day
- 2 tablets (8 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 2 tablets (8 mg) by oral route every 6-8 hours as needed not to exceed 3 doses in 24 hours
- 2 capsules (8 mg) by oral route every 8 hours as needed
- 2 capsules (8 mg) by oral route every 6-8 hours as needed not toexceed 3 doses in 24 hours
- 2 capsules (8 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 2 tablets (8 mg) by oral route every 8 hours as needed
- 2 capsules (12 mg) by oral route 3 times per day
- 2 capsules (12 mg) by oral route every 6 hours as needed not to exceed 3 doses in 24 hours
- 2 capsules (12 mg) by oral route every 8 hours as needed
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- fluvoxamine
- Luvox Cr
Contraindicated
- Acid Controller
- Acid Controller Complete
- Acid Reducer (cimetidine)
- Acid Reducer (famotidine)
- Acid Reducer Complete (famot)
- Acid Relief (cimetidine)
- acyclovir
- acyclovir sodium
- Altavera (28)
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Amethia
- Amethia Lo
- Amethyst
- amiodarone
- amiodarone in dextrose,iso-osm
- Apri
- Aranelle (28)
- artemether-lumefantrine
- Aubra
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- Aviane
- Azurette (28)
- Balziva (28)
- Beyaz
- Brevicon (28)
- Briellyn
- Calan
- Calan Sr
- Camila
- Camrese
- Camrese Lo
- Caziant (28)
- Chateal
- cimetidine
- Coartem
- Complete
- Cordarone
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- deferasirox
- Depo-provera
- Depo-subq Provera 104
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- disopyramide
- dronedarone
- droperidol
- drospirenone-e.estradiol-lm.FA
- drospirenone-ethinyl estradiol
- Dual Action Complete
- Duexis
- Elinest
- Emoquette
- Enpresse
- Enskyce
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estrostep Fe-28
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- Exjade
- Falmina (28)
- famotidine
- famotidine (PF)
- famotidine (PF)-NaCl (iso-os)
- famotidine-Ca carb-mag hydrox
- Femcon Fe
- Generess Fe
- Geodon
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- Heartburn Prevention
- Heartburn Relief
- Heartburn Relief (famotidine)
- Heather
- ibuprofen-famotidine
- Introvale
- Jencycla
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kariva (28)
- Kelnor 1/35 (28)
- Kurvelo
- L norgest&E estradiol-E estrad
- Larin 1/20 (21)
- Larin Fe
- Leena 28
- Lessina
- Levaquin
- Levaquin In 5 % Dextrose
- levofloxacin
- levofloxacin in D5W
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- Lo Loestrin Fe
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- Loryna (28)
- Loseasonique
- Low-ogestrel (28)
- Lutera (28)
- Lyza
- Marlissa
- medroxyprogesterone
- mexiletine
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- Minastrin 24 Fe
- Mircette (28)
- Mirena
- Modicon (28)
- Mono-linyah
- Mononessa (28)
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Multaq
- My Way
- Myzilra
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Nexplanon
- Next Choice One Dose
- Nexterone
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norfloxacin
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Noroxin
- Norpace
- Norpace Cr
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Nuvaring
- Ocella
- ofloxacin
- Ogestrel (28)
- Orap
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- Pacerone
- Pepcid
- Pepcid Ac
- Pepcid Complete
- Philith
- pimozide
- Pimtrea (28)
- Pirmella
- Plan B One-step
- Portia
- Previfem
- propafenone
- Quartette
- Quasense
- Reclipsen (28)
- Rythmol
- Safyral
- Seasonique
- Sprintec (28)
- Sronyx
- Syeda
- Tagamet Hb
- Tarka
- thioridazine
- ticlopidine
- Tilia Fe
- trandolapril-verapamil
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- Trinessa (28)
- Trivora (28)
- Tums Dual Action
- valacyclovir
- Valtrex
- Velivet Triphasic Regimen (28)
- vemurafenib
- verapamil
- Verelan
- Verelan Pm
- Vestura (28)
- Viorele (28)
- Vyfemla (28)
- Wera (28)
- Wymzya Fe
- Yasmin (28)
- Yaz 28
- Zarah
- Zelboraf
- Zenchent (28)
- Zenchent Fe
- Zeosa
- zileuton
- ziprasidone HCl
- ziprasidone mesylate
- Zovia 1/35E (28)
- Zovia 1/50E (28)
- Zovirax
- Zyflo
- Zyflo Cr
Severe
Moderate
- Ablavar
- alfuzosin
- Anzemet
- Apokyn
- apomorphine
- arsenic trioxide
- bedaquiline
- Betapace
- Betapace Af
- Caprelsa
- Celexa
- citalopram
- clozapine
- Clozaril
- Complera
- crizotinib
- dasatinib
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Edurant
- emtricitab-rilpivirine-tenofov
- eribulin
- escitalopram oxalate
- ezogabine
- Fareston
- Fazaclo
- gadofosveset trisodium
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Invega
- Invega Sustenna
- Invirase
- Istodax
- Kaletra
- lapatinib
- Lexapro
- lopinavir-ritonavir
- methadone
- Methadone Intensol
- Methadose
- Nexavar
- nilotinib
- Noxafil
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- paliperidone
- paliperidone palmitate
- pasireotide
- pazopanib
- posaconazole
- Potiga
- Qualaquin
- quetiapine
- quinine sulfate
- rilpivirine
- romidepsin
- saquinavir mesylate
- Seroquel
- Seroquel Xr
- Signifor
- Sirturo
- sorafenib
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- Tasigna
- telavancin
- tetrabenazine
- Tikosyn
- toremifene
- Trisenox
- Tykerb
- Uroxatral
- vandetanib
- Versacloz
- Vibativ
- Votrient
- Xalkori
- Xenazine
- Zofran
- Zofran Odt
- Zuplenz
- None
Contraindicated
- Hypotension
- Psychotic disorder
- Severe hepatic disease
Severe
Moderate
- Bradycardia
- Kidney disease with reduction in GFR
ZANAFLEX (TIZANIDINE HCL)
- Muscle spasm
- Muscle spasticity of cerebral origin
- Muscle spasticity of spinal origin
- None
- Constipation
- Dizziness
- Drowsy
- Dysarthria
- General weakness
- Pharyngitis
- Rhinitis
- Sedation
- Skin rash
- Xerostomia
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Bradycardia
- Drug-induced psychosis
- Hallucinations
- Hypotension
- Seizure disorder
- Syncope
- Toxic amblyopia
- Delusional disorder
- Dyskinesia
- Nervousness
- Orthostatic hypotension
- Tremor
- Urinary tract infection
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Angioedema
- Exfoliative dermatitis
- Hepatitis
- Paresthesia
- Stevens-johnson syndrome
- Ventricular tachycardia
Less Severe
- Arthralgias
- Depression
- Urticaria
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Tizanidine
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Tizanidine
- Severity Level:
C
- Additional Notes:
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Tizanidine
Use caution, excretion expected due to lipid solubility.
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Use caution, excretion expected due to lipid solubility. |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Tizanidine
Neuro/Psych-High incidence of sedation and cognitive impairment. Cardiovascular-Central alpha-adrenergic agonist activity can lead to orthostatic hypotension and falls. Renal-Four-fold lower clearance in the elderly.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | Y | Y | Y | N | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- None
Muscle spasm | |
M62.83 | Muscle spasm |
M62.830 | Muscle spasm of back |
M62.831 | Muscle spasm of calf |
M62.838 | Other muscle spasm |
R25.2 | Cramp and spasm |
Muscle spasticity of cerebral origin | |
M62.83 | Muscle spasm |
M62.830 | Muscle spasm of back |
M62.831 | Muscle spasm of calf |
M62.838 | Other muscle spasm |
R25.2 | Cramp and spasm |
Muscle spasticity of spinal origin | |
M62.83 | Muscle spasm |
M62.830 | Muscle spasm of back |
M62.831 | Muscle spasm of calf |
M62.838 | Other muscle spasm |
R25.2 | Cramp and spasm |
0-9 | A-Z |
---|---|
M62.83 | Muscle spasm |
M62.83 | Muscle spasm |
M62.83 | Muscle spasm |
M62.830 | Muscle spasm of back |
M62.830 | Muscle spasm of back |
M62.830 | Muscle spasm of back |
M62.831 | Muscle spasm of calf |
M62.831 | Muscle spasm of calf |
M62.831 | Muscle spasm of calf |
M62.838 | Other muscle spasm |
M62.838 | Other muscle spasm |
M62.838 | Other muscle spasm |
R25.2 | Cramp and spasm |
R25.2 | Cramp and spasm |
R25.2 | Cramp and spasm |