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DSUVIA (sufentanil citrate)
- Acute pain
30 mcg sublingual tablet in applicator
- Place 1 tablet (30 mcg) by sublingual route once, may repeat at 1 hour intervals as needed; do not exceed 12 tablets in 24 hours
Acute pain
- Place 1 tablet (30 mcg) by sublingual route once
- Place 1 tablet (30 mcg) by sublingual route once, may repeat at 1 hour intervals as needed; do not exceed 12 tablets in 24 hours
- Depade
- naltrexone
- naltrexone microspheres
- Revia
- Vivitrol
Contraindicated
- amoxicil-clarithromy-lansopraz
- Azilect
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- clarithromycin
- conivaptan in 5 % dextrose
- Crixivan
- Diflucan
- Eldepryl
- elvitegr-cobicist-emtric-tenof
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- Incivek
- indinavir
- Invirase
- isocarboxazid
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- linezolid
- lopinavir-ritonavir
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- nefazodone
- nelfinavir
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- Parnate
- phenelzine
- posaconazole
- Prevpac
- procarbazine
- rasagiline
- ritonavir
- saquinavir mesylate
- selegiline HCl
- sodium oxybate
- Sporanox
- Sporanox Pulsepak
- Stribild
- telaprevir
- telithromycin
- tranylcypromine
- Vaprisol
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- voriconazole
- Xyrem
- Zelapar
- Zyvox
Severe
Moderate
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- aprepitant
- atazanavir
- Buprenex
- buprenorphine
- buprenorphine-naloxone
- butorphanol tartrate
- Butrans
- Calan
- Calan Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- cimetidine
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- darunavir
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- dronedarone
- Emend
- Fanatrex
- fosamprenavir
- fosaprepitant
- gabapentin
- gabapentin enacarbil
- Gleevec
- Gralise
- Gralise 30-day Starter Pack
- Heartburn Relief
- Horizant
- imatinib
- isoniazid-rifamp-pyrazinamide
- Lexiva
- Matzim La
- Multaq
- nalbuphine
- Neurontin
- Prezista
- Reyataz
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Suboxone
- Tagamet Hb
- Tarka
- Taztia Xt
- Tiazac
- trandolapril-verapamil
- verapamil
- Verelan
- Verelan Pm
- Zubsolv
- Gastrointestinal obstruction
- Paralytic ileus
Contraindicated
- Debilitation
- Disease of liver
- Drug abuse
- History of opioid overdose
- Intracranial hypertension
- Lower seizure threshold
- Seizure disorder
- Sleep apnea
Severe
Moderate
- Adrenal cortical insufficiency
- Bradycardia
- Chronic disease of respiratory system
- Decreased cardiac function
- Kidney disease with reduction in GFR
- Spasm of sphincter of oddi
DSUVIA (sufentanil citrate)
- Acute pain
- Bradycardia
- Hypotension
- Respiratory depression
- Dizziness
- Drowsy
- Headache disorder
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- None
- Acute abdominal pain
- Dyspepsia
- Syncope
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute respiratory distress syndrome
- Acute respiratory insufficiency
- Adrenal cortical insufficiency
- Anaphylaxis
- Androgen deficiency
- Apnea
- Atelectasis
- Bradypnea
- Hypertension
- Hypoxia
- Ileus
- Renal failure
- Seizure disorder
- Sinus tachycardia
- Sleep apnea
- Urinary retention
Less Severe
- Abdominal distension
- Acute confusion
- Altered mental status
- Biliary spasm
- Constipation
- Diarrhea
- Eructation
- Euphoria
- Flatulence
- Flushing
- Gastritis
- Hallucinations
- Hemiparesis
- Hiccups
- Hyperhidrosis
- Insomnia
- Lethargy
- Memory impairment
- Muscle spasm
- Oliguria
- Oral hypoesthesia
- Orthostatic hypotension
- Pruritus of skin
- Sedation
- Skin rash
- Symptoms of anxiety
- Urinary hesitancy
- Xerostomia
Contraindicated
None
Severe Precaution
Sufentanil (SL)
Safety and efficacy not established in pediatric patients; sublingual dosage form is not recommended for younger children.
- 1 Day – 18 Years
- Safety and efficacy not established in pediatric patients; sublingual dosage form is not recommended for younger children.
Management or Monitoring Precaution
None
Sufentanil
- Severity Level:
2
- Additional Notes: Withdrawal and neonatal abstinence syndrome may occur.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Sufentanil Citrate
Insuff data avail; molecular wt low enough for possible breastmilk excretion.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insuff data avail; molecular wt low enough for possible breastmilk excretion. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Sufentanil
Pulmonary-DO NOT USE in opioid intolerance. Life threatening respiratory depression risk due to altered pharmacokinetics (poor fat stores, muscle wasting, or altered clearance). Monitor closely at initiation and dose titration. Consider naloxone Rx. Neuro/Psych-Risk for confusion, delirium and falls. Avoid treatment with 3 or more CNS active agents. Gastrointestinal-Increased rate of constipation in the elderly. Cardiovascular-Vasodilation may predispose to orthostatic hypotension.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | Y | Y | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- None
| Acute pain | |
| G89.1 | Acute pain, not elsewhere classified |
| G89.11 | Acute pain due to trauma |
| G89.18 | Other acute postprocedural pain |
| 0-9 | A-Z |
|---|---|
| G89.1 | Acute pain, not elsewhere classified |
| G89.11 | Acute pain due to trauma |
| G89.18 | Other acute postprocedural pain |
Formulary Reference Tool