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ZEMPLAR (PARICALCITOL)
- Hyperparathyroidism secondary to chronic renal failure
- Zemplar Intravenous Solution
- Zemplar Capsule
- Paricalcitol Intravenous Solution
- Paricalcitol Capsule
- By Indication
2 mcg/mL intravenous solution
- Dosage information is not available
5 mcg/mL intravenous solution
- Dosage information is not available
1 mcg capsule
- 1 capsule (1 mcg) by oral route once daily
2 mcg capsule
- 1 capsule (2 mcg) by oral route once daily
2 mcg/mL intravenous solution
- Dosage information is not available
5 mcg/mL intravenous solution
- Dosage information is not available
1 mcg capsule
- 1 capsule (1 mcg) by oral route once daily
2 mcg capsule
- 1 capsule (2 mcg) by oral route once daily
4 mcg capsule
- 1 capsule (4 mcg) by oral route 3 times per week
Hyperparathyroidism secondary to chronic renal failure
- Inject 0.04 mcg/kg by intravenous route every other day during dialysis
- Inject 0.1 mcg/kg by intravenous route every other day during dialysis
- Inject 0.24 mcg/kg by intravenous route every other day during dialysis
- 1 capsule (1 mcg) by oral route once daily
- 1 capsule (1 mcg) by oral route 3 times per week
- 2 capsules (2 mcg) by oral route 3 times per week
- 1 capsule (2 mcg) by oral route once daily
- 1 capsule (2 mcg) by oral route 3 times per week
- 2 capsules (2 mcg) by oral route once daily
- 2 capsules (4 mcg) by oral route 3 times per week
- None
Contraindicated
- None
Severe
Moderate
- None
- Hypervitaminosis D
Contraindicated
- Hypercalcemia
- Hyperphosphatemia
Severe
Moderate
- Digitalis toxicity
ZEMPLAR (PARICALCITOL)
- Hyperparathyroidism secondary to chronic renal failure
- Edema
- Hypertension
- Skin rash
- Vertigo
- Diarrhea
- Dizziness
- Nausea
- Sore throat
- Vomiting
More Frequent
Severe
Less Severe
- Arthritis
- Bacterial sepsis
- Chest pain
- Dehydration
- Fever
- Fungal infection
- Gastrointestinal hemorrhage
- Hypervolemia
- Hypoglycemic disorder
- Hypotension
- Pneumonia
- Skin ulcer
- Urinary tract infection
- Abdominal pain with cramps
- Back pain
- Chills
- Constipation
- Cough
- Cramps in legs
- Depression
- Edema
- Headache disorder
- Insomnia
- Malaise
- Muscle spasm
- Pain
- Palpitations
- Pruritus of skin
- Sinusitis
- Symptoms of anxiety
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anemia
- Angioedema
- Anorexia
- Atrial flutter
- Cardiac arrest
- Cardiac arrhythmia
- Cerebrovascular accident
- Dizziness
- Glaucoma
- Hypercalcemia
- Hyperkalemia
- Hyperphosphatemia
- Hypertension
- Hypocalcemia
- Hypotension
- Kidney disease with reduction in GFR
- Laryngeal edema
- Pulmonary edema
- Rectal bleeding
- Skin rash
- Syncope
- Urticaria
Less Severe
- Acne vulgaris
- Acute abdominal pain
- Acute confusion
- Agitation
- Alopecia
- Anorexia
- Arthralgias
- Chest pain
- Conjunctival hyperemia
- Conjunctivitis
- Constipation
- Cough
- Delirium
- Diarrhea
- Dysgeusia
- Dysphagia
- Dyspnea
- Earache
- Erectile dysfunction
- Facial edema
- Fatigue
- Gait abnormality
- Gastritis
- General weakness
- Headache disorder
- Hirsutism
- Hypesthesia
- Influenza
- Injection site sequelae
- Insomnia
- Lymphadenopathy
- Mastalgia
- Myoclonus
- Nervousness
- Night sweats
- Pain
- Paresthesia
- Pharyngitis
- Photophobia
- Polydipsia
- Pruritus of skin
- Syncope
- Twitching
- Upper respiratory infection
- Urticaria
- Wheezing
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Paricalcitol (injection)
Safety and efficacy not established age < 5 years.
Safety and efficacy not established age < 10 years.
- 1 Day – 5 Years
- Safety and efficacy not established age < 5 years.
- 1 Day – 10 Years
- Safety and efficacy not established age < 5 years.
Paricalcitol (oral)
Safety and efficacy not established age < 5 years.
Safety and efficacy not established age < 10 years.
- 1 Day – 5 Years
- Safety and efficacy not established age < 10 years.
- 1 Day – 10 Years
- Safety and efficacy not established age < 10 years.
Paricalcitol
- Severity Level:
2
- Additional Notes: Insuff human data avail; animal data sug dev tox
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Paricalcitol
Insufficient human data available; monitor infant for hypercalcemia.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available; monitor infant for hypercalcemia. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Hyperparathyroidism secondary to chronic renal failure | |
| N25.81 | Secondary hyperparathyroidism of renal origin |
| 0-9 | A-Z |
|---|---|
| N25.81 | Secondary hyperparathyroidism of renal origin |
Formulary Reference Tool