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LUPRON DEPOT (LEUPROLIDE ACETATE)
- Advanced prostatic carcinoma
- Anemia due to bleeding uterine leiomyoma
- Endometriosis
- Lupron Depot Intramuscular Syringe Kit
- Lupron Depot (6 Month) Intramuscular Syringe Kit
- Lupron Depot (4 Month) Intramuscular Syringe Kit
- Lupron Depot (3 Month) Intramuscular Syringe Kit
- By Indication
Lupron Depot 3.75 mg intramuscular syringe kit
- Inject 3.75 mg by intramuscular route once a month
Lupron Depot 7.5 mg intramuscular syringe kit
- Inject 7.5 mg by intramuscular route once a month
(6 Month) 45 mg intramuscular syringe kit
- Dosage information is not available
30 mg (4 month) intramuscular syringe kit
- Inject 30 mg by intramuscular route every 4 months
11.25 mg (3 month) intramuscular syringe kit
- Inject 11.25 mg by intramuscular route every 3 months
22.5 mg (3 month) intramuscular syringe kit
- Inject 22.5 mg by intramuscular route every 3 months
Advanced prostatic carcinoma
- Inject 30 mg by intramuscular route every 4 months
- Inject 22.5 mg by intramuscular route every 3 months
- Inject 7.5 mg by intramuscular route once a month
Anemia due to bleeding uterine leiomyoma
- Inject 3.75 mg by intramuscular route once a month
- Inject 3.75 mg by intramuscular route once a month for 6 months
- Inject 11.25 mg by intramuscular route once
Endometriosis
- Inject 3.75 mg by intramuscular route once a month
- Inject 11.25 mg by intramuscular route every 3 months
- None
Contraindicated
- amiodarone
- amiodarone in dextrose,iso-osm
- artemether-lumefantrine
- Coartem
- Cordarone
- disopyramide
- dronedarone
- droperidol
- Geodon
- Multaq
- Nexterone
- Norpace
- Norpace Cr
- Orap
- Pacerone
- pimozide
- thioridazine
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- Ablavar
- alfuzosin
- Anzemet
- Apokyn
- apomorphine
- arsenic trioxide
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- bedaquiline
- Betapace
- Betapace Af
- Caprelsa
- Celexa
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- citalopram
- clozapine
- Clozaril
- Complera
- crizotinib
- dasatinib
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Edurant
- emtricitab-rilpivirine-tenofov
- eribulin
- escitalopram oxalate
- ezogabine
- Fareston
- Fazaclo
- gadofosveset trisodium
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Invega
- Invega Sustenna
- Invirase
- Istodax
- Kaletra
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- levofloxacin
- levofloxacin in D5W
- Lexapro
- lopinavir-ritonavir
- methadone
- Methadone Intensol
- Methadose
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nexavar
- nilotinib
- norfloxacin
- Noroxin
- Noxafil
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- paliperidone
- paliperidone palmitate
- pasireotide
- pazopanib
- posaconazole
- Potiga
- propafenone
- Qualaquin
- quetiapine
- quinine sulfate
- rilpivirine
- romidepsin
- Rythmol
- saquinavir mesylate
- Seroquel
- Seroquel Xr
- Signifor
- Sirturo
- sorafenib
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- Tasigna
- telavancin
- tetrabenazine
- Tikosyn
- toremifene
- Trisenox
- Tykerb
- Uroxatral
- vandetanib
- vemurafenib
- Versacloz
- Vfend
- Vfend Iv
- Vibativ
- voriconazole
- Votrient
- Xalkori
- Xenazine
- Zelboraf
- Zofran
- Zofran Odt
- Zuplenz
- Lactating mother
Contraindicated
- Acute myocardial infarction
- Cerebrovascular accident
- Chronic heart failure
- Congenital long QT syndrome
- Depression
- Hypokalemia
- Hypomagnesemia
- Osteopenia
- Pregnancy
- Prolonged QT interval
Severe
Moderate
- Alcoholism
- Diabetes mellitus
- Disease of liver
- Hypercholesterolemia
- Hypertension
- Increased cardiovascular event risk
- Obesity
- Osteopenia
- Seizure disorder
- Tobacco smoker
- Urinary tract obstruction
- Vertebral metastases
LUPRON DEPOT (LEUPROLIDE ACETATE)
- Advanced prostatic carcinoma
- Anemia due to bleeding uterine leiomyoma
- Endometriosis
- None
- Abnormal vaginal bleeding
- Amenorrhea
- Depression
- Dizziness
- Drug-induced hot flash
- Dyspepsia
- Edema
- Fatigue
- Headache disorder
- Hyperhidrosis
- Malaise
- Nausea
- Pain
- Stinging of skin
- Testicular atrophy
- Upper respiratory infection
- Vaginitis
- Vomiting
- Weight gain
More Frequent
Severe
Less Severe
- Arthralgias
- Deepening voice in females
- Female hirsutism
- Infection
- Myalgias
- Acne vulgaris
- Constipation
- Erectile dysfunction
- General weakness
- Gynecomastia
- Injection site sequelae
- Insomnia
- Libido changes
- Mastalgia
- Mood changes
- Nervousness
- Paresthesia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute myocardial infarction
- Anaphylaxis
- Angina
- Asthma
- Cellulitis
- Cerebrovascular accident
- Chronic heart failure
- Diabetes mellitus
- Drug-induced hepatitis
- Epididymitis
- Fracture
- Granulocytopenic disorder
- Hemoptysis
- Hepatocellular damage
- Hepatomegaly
- Hypertension
- Hypotension
- Interstitial lung disease
- Leukopenia
- Lymphadenopathy
- Ophthalmoplegia
- Osteopenia
- Peptic ulcer
- Pituitary apoplexy
- Prolonged QT interval
- Pulmonary edema
- Pulmonary emphysema
- Pulmonary thromboembolism
- Pyelonephritis
- Seizure disorder
- Skin rash
- Suicidal ideation
- Syncope
- Transient cerebral ischemia
- Urticaria
- Visual changes
Less Severe
- Aggressive behavior
- Agitation
- Anorexia
- Balanitis
- Deep venous thrombosis
- Dysphagia
- Ecchymosis
- Eructation
- Fever
- Glossitis
- Hyperglycemia
- Hypesthesia
- Induration of skin
- Irritability
- Lethargy
- Melanosis
- Muscle atrophy
- Peripheral neuropathy
- Skin photosensitivity
- Tenosynovitis
- Testicular pain
- Urinary tract infection
Contraindicated
None
Severe Precaution
Leuprolide (Prostate CA)
Dose form or strength may not be appropriate for precocious puberty in pediatric patients.
- 1 Day – 18 Years
- Dose form or strength may not be appropriate for precocious puberty in pediatric patients.
Management or Monitoring Precaution
None
Leuprolide
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
Leuprolide
Contraindicated per manufacturer
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Contraindicated per manufacturer |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Advanced prostatic carcinoma | |
| C61 | Malignant neoplasm of prostate |
| Anemia due to bleeding uterine leiomyoma | |
| D25 | Leiomyoma of uterus |
| D25.0 | Submucous leiomyoma of uterus |
| D25.1 | Intramural leiomyoma of uterus |
| D25.2 | Subserosal leiomyoma of uterus |
| D25.9 | Leiomyoma of uterus, unspecified |
| Endometriosis | |
| N80 | Endometriosis |
| N80.0 | Endometriosis of uterus |
| N80.1 | Endometriosis of ovary |
| N80.2 | Endometriosis of fallopian tube |
| N80.3 | Endometriosis of pelvic peritoneum |
| N80.4 | Endometriosis of rectovaginal septum and vagina |
| N80.5 | Endometriosis of intestine |
| N80.6 | Endometriosis in cutaneous scar |
| N80.8 | Other endometriosis |
| N80.9 | Endometriosis, unspecified |
| 0-9 | A-Z |
|---|---|
| C61 | Malignant neoplasm of prostate |
| D25 | Leiomyoma of uterus |
| D25.0 | Submucous leiomyoma of uterus |
| D25.1 | Intramural leiomyoma of uterus |
| D25.2 | Subserosal leiomyoma of uterus |
| D25.9 | Leiomyoma of uterus, unspecified |
| N80 | Endometriosis |
| N80.0 | Endometriosis of uterus |
| N80.1 | Endometriosis of ovary |
| N80.2 | Endometriosis of fallopian tube |
| N80.3 | Endometriosis of pelvic peritoneum |
| N80.4 | Endometriosis of rectovaginal septum and vagina |
| N80.5 | Endometriosis of intestine |
| N80.6 | Endometriosis in cutaneous scar |
| N80.8 | Other endometriosis |
| N80.9 | Endometriosis, unspecified |
Formulary Reference Tool