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PERPHENAZINE (perphenazine)
- Schizophrenia
- Nausea and vomiting
16 mg tablet
- 1 tablet (16 mg) by oral route 2 times per day
2 mg tablet
- 2 tablets (4 mg) by oral route 3 times per day
4 mg tablet
- 1 tablet (4 mg) by oral route 2 times per day
8 mg tablet
- 1 tablet (8 mg) by oral route 2 times per day
Nausea and vomiting
- 1 tablet (2 mg) by oral route 4 times per day
- 2 tablets (4 mg) by oral route 3 times per day
- 2 tablets (4 mg) by oral route 4 times per day
- 1 tablet (4 mg) by oral route 3 times per day
- 1 tablet (4 mg) by oral route 4 times per day
- 1 tablet (4 mg) by oral route 2 times per day
- 2 tablets (4 mg) by oral route 2 times per day
- 2 tablets (8 mg) by oral route 2 times per day
- 2 tablets (8 mg) by oral route 3 times per day
- 1 tablet (8 mg) by oral route 2 times per day
Schizophrenia
- 2 tablets (4 mg) by oral route 3 times per day
- 1 tablet (4 mg) by oral route 3 times per day
- 1 tablet (8 mg) by oral route 3 times per day
- 2 tablets (8 mg) by oral route 3 times per day
- 1 tablet (16 mg) by oral route 4 times per day
- 1 tablet (16 mg) by oral route 2 times per day
- metoclopramide HCl
- Metozolv Odt
- Orap
- pimozide
- Reglan
Contraindicated
- Apokyn
- apomorphine
- cabergoline
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Comtan
- entacapone
- lithium carbonate
- lithium citrate
- Lithobid
- Mirapex
- Mirapex Er
- pramipexole
- Requip
- Requip Xl
- ropinirole
- Sinemet
- Sinemet Cr
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
Severe
Moderate
- Alagesic Lq
- amobarbital
- Amytal
- Anaspaz
- Aplenzin
- Ascomp With Codeine
- Atropen
- atropine
- belladonna alkaloids-opium
- Belladonna-opium
- Belladonna-phenobarbital
- Bentyl
- benztropine
- Bupap
- Buproban
- bupropion HBr
- bupropion HCl
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- Cantil
- Capacet
- chlordiazepoxide-clidinium
- chlorphen-pseudoeph-bellad alk
- codeine-butalbital-ASA-caff
- Cogentin
- Cuvposa
- dicyclomine
- diphenoxylate-atropine
- Ditropan Xl
- Donnatal
- Duodote
- Ed-spaz
- edrophonium Cl-atropine
- Enlon-plus
- Esgic
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- flavoxate
- Forfivo Xl
- Gelnique
- Glycate
- glycopyrrolate
- Hydrocodone Compound
- hydrocodone-homatropine
- Hydromet
- Hyophen
- hyoscyamine sulfate
- Hyosyne
- Lamisil
- Levbid
- Levsin
- Levsin/sl
- Librax (with Clidinium)
- Lomotil
- Luminal
- Margesic
- Marten-tab
- mepenzolate bromide
- methen-hyos-me blue-ba-salicyl
- methen-hyosc-m.blue-sal-naphos
- methen-sod phos-meth blue-hyos
- methscopolamine
- mth-me blue-sod phos-phsal-hyo
- Mysoline
- Nembutal Sodium
- Nulev
- Oscimin
- Oscimin Sl
- Oscimin Sr
- oxybutynin
- oxybutynin chloride
- Oxytrol
- Oxytrol For Women
- Pamine
- Pamine Forte
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phosphasal
- pralidoxime-atropine
- primidone
- propantheline
- Prosed/ds (atropine Free)
- Respa-ar
- Robinul
- Robinul Forte
- scopolamine base
- scopolamine HBr
- secobarbital sodium
- Seconal Sodium
- Symax Duotab
- Symax Fastabs
- Symax-sl
- Symax-sr
- Tencon
- terbinafine
- Transderm-scop
- trihexyphenidyl
- Tussigon
- Ur N-c
- Urelle
- Uretron D-s
- Uribel
- Urimar-t
- Urin Ds
- Urogesic-blue
- Uryl
- Ustell
- Uta
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Zebutal
- Zyban
- Coma
- Neuroleptic malignant syndrome
- Stupor
Contraindicated
- Acute myocardial infarction
- Benign prostatic hyperplasia with lower urinary tract sx
- Carcinoma of breast
- Cardiac arrhythmia
- Congenital long QT syndrome
- Disease of liver
- Extrapyramidal disease
- Glaucoma
- Metabolic syndrome X
- Myocardial ischemia
- Organophos insecticide poisoning
- Prolonged QT interval
- Senile dementia
- Tardive dyskinesia
- Torsades de pointes
- Urinary retention
Severe
Moderate
- Alcoholism
- Anemia
- Angina
- Bradycardia
- Chronic disease of respiratory system
- Chronic heart failure
- CYp2d6 poor metabolizer
- Hyperglycemia
- Hyperprolactinemia
- Leukopenia
- Neutropenic disorder
- Obesity
- Orthostatic hypotension
- Parkinsonism
- Predisposition to aspiration
- Seizure disorder
- Thrombocytopenic disorder
- Weight gain
PERPHENAZINE (perphenazine)
- Schizophrenia
- Nausea and vomiting
- Akathisia
- Blurred vision
- Extrapyramidal disease
- Hypotension
- Pigmentary retinopathy
- Syncope
- Tardive dyskinesia
- Constipation
- Decreased sweating
- Dizziness
- Drowsy
- Nasal congestion
- Orthostatic hypotension
- Sialorrhea
- Xerostomia
More Frequent
Severe
Less Severe
- Contact dermatitis
- Dysuria
- Skin photosensitivity
- Abnormal sexual function
- Breast engorgement
- Galactorrhea not associated with childbirth
- Irregular menstrual periods
- Mastalgia
- Weight gain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Agranulocytosis
- Heat stroke
- Hypothermia
- Leukopenia
- Melanosis
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Priapism
- Prolonged QT interval
- Seizure disorder
- Torsades de pointes
- Visual changes
Less Severe
- Fever
- Photophobia
Contraindicated
None
Severe Precaution
Perphenazine
Not recommended for pediatrics under 12 years of age.
- 1 Day – 12 Years
- Not recommended for pediatrics under 12 years of age.
Management or Monitoring Precaution
None
Perphenazine
- Severity Level:
2
- Additional Notes: No fda category; neonate complications(resp,gi,cns) w/exposure in 3rd trimester
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Perphenazine
Low amnt excr w/similar drug chlorpromazine, resulting in infant drowsiness
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Low amnt excr w/similar drug chlorpromazine, resulting in infant drowsiness |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Perphenazine
Neuro/Psych-Inc risk of tardive dyskinesia. CNS effects; sedation, cognitive impair and inc fall risk. Avoid use for behav probs of dementia or delirium unless failed nonpharm options. Inc risk of stroke, cognit decline, and death when used w/senile dementia. Max 8mg/day. Endocrine-May exacerbate or cause SIADH or hyponatremia. Cardiovascular-May cause orthostatic hypotens at higher doses. Gastrointestinal-May cause or worsen constipation. Genitourinary-Avoid in pts w/urinary reten.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- There may be a slightly increased risk of serious, possibly fatal side effects (such as heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.
| Nausea and vomiting | |
| R11 | Nausea and vomiting |
| R11.2 | Nausea with vomiting, unspecified |
| Schizophrenia | |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| 0-9 | A-Z |
|---|---|
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| R11 | Nausea and vomiting |
| R11.2 | Nausea with vomiting, unspecified |
Formulary Reference Tool