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CHLORPROMAZINE HCL (CHLORPROMAZINE HCL)
- Acute intermittent porphyria
- Intractable hiccups
- Mania associated with bipolar disorder
- Nausea and vomiting
- Schizophrenia
- Tetanus adjunct treatment
chlorpromazine 25 mg/mL injection solution
- Inject 1 milliliter (25 mg) by intramuscular route 3 times per day
Acute intermittent porphyria
- Inject 1 milliliter (25 mg) by intramuscular route 3 times per day
- Inject 1 milliliter (25 mg) by intramuscular route 4 times per day
Intractable hiccups
- Inject 1 milliliter (25 mg) by intramuscular route 3 times per day
- Inject 1 milliliter (25 mg) by intramuscular route 4 times per day
- Inject 2 milliliters (50 mg) by intramuscular route 3 times per day
- Inject 2 milliliters (50 mg) by intramuscular route 4 times per day
Mania associated with bipolar disorder
- Inject 1 milliliter (25 mg) by intramuscular route x 1 dose slowly, deep into upper outer quadrant of buttock; give additional 25 mg in 1 hour if necessary as needed
- Inject 1 milliliter (25 mg) by intramuscular route x 1 dose slowly, deep into upper outer quadrant of buttock; give additional 50 mg in 1 hour if necessary as needed
- Inject 2 milliliters (50 mg) by intramuscular route every 4 hours slowly, deep into upper outer quadrant of buttock as needed
- Inject 2 milliliters (50 mg) by intramuscular route every 6 hours slowly, deep into upper outer quadrant of buttock as needed
- Inject 3 milliliters (75 mg) by intramuscular route every 4 hours slowly, deep into upper outer quadrant of buttock as needed
- Inject 3 milliliters (75 mg) by intramuscular route every 6 hours slowly, deep into upper outer quadrant of buttock as needed
- Inject 4 milliliters (100 mg) by intramuscular route every 4 hours slowly, deep into upper outer quadrant of buttock as needed
- Inject 4 milliliters (100 mg) by intramuscular route every 6 hours slowly, deep into upper outer quadrant of buttock as needed
- Inject 5 milliliters (125 mg) by intramuscular route every 4 hours slowly, deep into upper outer quadrant of buttock as needed
- Inject 5 milliliters (125 mg) by intramuscular route every 6 hours slowly, deep into upper outer quadrant of buttock as needed
Nausea and vomiting
- Inject 1 milliliter (25 mg) by intramuscular route every 3 hours as needed until vomiting stops
- Inject 1 milliliter (25 mg) by intramuscular route every 4 hours as needed until vomiting stops
- Inject 2 milliliters (50 mg) by intramuscular route every 3 hours as needed until vomiting stops
- Inject 2 milliliters (50 mg) by intramuscular route every 4 hours as needed until vomiting stops
- amiodarone
- amiodarone in dextrose,iso-osm
- artemether-lumefantrine
- Coartem
- Cordarone
- disopyramide
- dronedarone
- droperidol
- Geodon
- metoclopramide HCl
- Metozolv Odt
- Multaq
- Nexterone
- Norpace
- Norpace Cr
- Orap
- Pacerone
- pimozide
- Reglan
- ziprasidone HCl
- ziprasidone mesylate
Contraindicated
- Apokyn
- apomorphine
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- cabergoline
- Caprelsa
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Comtan
- dofetilide
- entacapone
- Fareston
- Invega
- Invega Sustenna
- Kaletra
- lithium carbonate
- lithium citrate
- Lithobid
- lopinavir-ritonavir
- Mirapex
- Mirapex Er
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- nilotinib
- paliperidone
- paliperidone palmitate
- pramipexole
- propafenone
- Qualaquin
- quetiapine
- quinine sulfate
- Requip
- Requip Xl
- ropinirole
- Rythmol
- Seroquel
- Seroquel Xr
- Sinemet
- Sinemet Cr
- sodium oxybate
- Soltamox
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- tamoxifen
- Tasigna
- tetrabenazine
- thioridazine
- Tikosyn
- toremifene
- vandetanib
- Xenazine
- Xyrem
Severe
Moderate
- Alagesic Lq
- alfuzosin
- amobarbital
- Amytal
- Anaspaz
- Anzemet
- Aplenzin
- Ascomp With Codeine
- Atropen
- atropine
- belladonna alkaloids-opium
- Belladonna-opium
- Belladonna-phenobarbital
- Bentyl
- benztropine
- Bupap
- Buproban
- bupropion HBr
- bupropion HCl
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- Cantil
- Capacet
- chlordiazepoxide-clidinium
- chlorphen-pseudoeph-bellad alk
- clozapine
- Clozaril
- codeine-butalbital-ASA-caff
- Cogentin
- Complera
- Cuvposa
- dasatinib
- dicyclomine
- diphenoxylate-atropine
- Ditropan Xl
- dolasetron
- Donnatal
- Duodote
- Ed-spaz
- edrophonium Cl-atropine
- Edurant
- emtricitab-rilpivirine-tenofov
- Enlon-plus
- Esgic
- Fazaclo
- fingolimod
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- flavoxate
- Forfivo Xl
- Gelnique
- Gilenya
- Glycate
- glycopyrrolate
- Hydrocodone Compound
- hydrocodone-homatropine
- Hydromet
- Hyophen
- hyoscyamine sulfate
- Hyosyne
- Inderal La
- Inderal Xl
- Innopran Xl
- lapatinib
- Levbid
- Levsin
- Levsin/sl
- Librax (with Clidinium)
- Lomotil
- Luminal
- Margesic
- Marten-tab
- mepenzolate bromide
- methen-hyos-me blue-ba-salicyl
- methen-hyosc-m.blue-sal-naphos
- methen-sod phos-meth blue-hyos
- methscopolamine
- mth-me blue-sod phos-phsal-hyo
- Mysoline
- Nembutal Sodium
- norfloxacin
- Noroxin
- Noxafil
- Nulev
- Oscimin
- Oscimin Sl
- Oscimin Sr
- oxybutynin
- oxybutynin chloride
- Oxytrol
- Oxytrol For Women
- Pamine
- Pamine Forte
- pasireotide
- pazopanib
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phosphasal
- pindolol
- posaconazole
- pralidoxime-atropine
- primidone
- propantheline
- propranolol
- propranolol-hydrochlorothiazid
- Prosed/ds (atropine Free)
- Respa-ar
- rilpivirine
- Robinul
- Robinul Forte
- scopolamine base
- scopolamine HBr
- secobarbital sodium
- Seconal Sodium
- Signifor
- Sprycel
- Symax Duotab
- Symax Fastabs
- Symax-sl
- Symax-sr
- Tencon
- Transderm-scop
- trihexyphenidyl
- Tussigon
- Tykerb
- Ur N-c
- Urelle
- Uretron D-s
- Uribel
- Urimar-t
- Urin Ds
- Urogesic-blue
- Uroxatral
- Uryl
- Ustell
- Uta
- Versacloz
- Votrient
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Zebutal
- Zyban
- Coma
- Neuroleptic malignant syndrome
- Stupor
Contraindicated
- Acute myocardial infarction
- Benign prostatic hyperplasia with lower urinary tract sx
- Carcinoma of breast
- Cardiac arrhythmia
- Congenital long QT syndrome
- Disease of liver
- Extrapyramidal disease
- Glaucoma
- Metabolic syndrome X
- Myocardial ischemia
- Organophos insecticide poisoning
- Prolonged QT interval
- Senile dementia
- Tardive dyskinesia
- Torsades de pointes
- Urinary retention
Severe
Moderate
- Alcoholism
- Anemia
- Angina
- Bradycardia
- Chronic disease of respiratory system
- Chronic heart failure
- Hyperglycemia
- Hyperprolactinemia
- Leukopenia
- Neutropenic disorder
- Obesity
- Orthostatic hypotension
- Parkinsonism
- Predisposition to aspiration
- Seizure disorder
- Thrombocytopenic disorder
- Tobacco smoker
- Weight gain
CHLORPROMAZINE HCL (CHLORPROMAZINE HCL)
- Acute intermittent porphyria
- Intractable hiccups
- Mania associated with bipolar disorder
- Nausea and vomiting
- Schizophrenia
- Tetanus adjunct treatment
- Akathisia
- Blurred vision
- Extrapyramidal disease
- Hypotension
- Pigmentary retinopathy
- Syncope
- Tardive dyskinesia
- Constipation
- Decreased sweating
- Dizziness
- Drowsy
- Nasal congestion
- Orthostatic hypotension
- Sialorrhea
- Xerostomia
More Frequent
Severe
Less Severe
- Contact dermatitis
- Dysuria
- Skin photosensitivity
- Abnormal sexual function
- Breast engorgement
- Galactorrhea not associated with childbirth
- Irregular menstrual periods
- Mastalgia
- Weight gain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Agranulocytosis
- Heat stroke
- Hypothermia
- Leukopenia
- Melanosis
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Priapism
- Prolonged QT interval
- Seizure disorder
- Torsades de pointes
- Visual changes
Less Severe
- Fever
- Photophobia
Contraindicated
None
Severe Precaution
Chlorpromazine
Not recommended in children under 6 months.
- 1 Day – 179 Days
- Not recommended in children under 6 months.
Management or Monitoring Precaution
None
Chlorpromazine Hydrochloride
- Severity Level:
2
- Additional Notes: No fda category; neonate complications (resp,gi,cns) w/exposure in 3rd trimester
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Chlorpromazine
Limited data suggest minimal excretion resulting in infant drowsiness
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Drug shown to have adverse effect | Limited data suggest minimal excretion resulting in infant drowsiness |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
Chlorpromazine
Neuro/Psych-Not recommended in the elderly. Inc risk of tardive dyskinesia. CNS effects; sedation, cognitive impairment and inc fall risk. Inc risk of stroke, cognitive decline, and death when used with senile dementia. Endocrine-May exacerbate or cause SIADH or hyponatremia. Cardiovascular-May cause bradycardia, orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen constipation. Urogenital-Avoid in patients w/ urinary retention.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
Precaution Exists
None
No Known Risk
None
- None
| Acute intermittent porphyria | |
| E80.21 | Acute intermittent (hepatic) porphyria |
| Intractable hiccups | |
| R06.6 | Hiccough |
| Mania associated with bipolar disorder | |
| F31.1 | Bipolar disorder, current episode manic without psychotic features |
| F31.10 | Bipolar disorder, current episode manic without psychotic features, unspecified |
| F31.11 | Bipolar disorder, current episode manic without psychotic features, mild |
| F31.12 | Bipolar disorder, current episode manic without psychotic features, moderate |
| F31.13 | Bipolar disorder, current episode manic without psychotic features, severe |
| F31.2 | Bipolar disorder, current episode manic severe with psychotic features |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| Nausea and vomiting | |
| R11 | Nausea and vomiting |
| R11.2 | Nausea with vomiting, unspecified |
| Schizophrenia | |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| Tetanus adjunct treatment | |
| A33 | Tetanus neonatorum |
| A34 | Obstetrical tetanus |
| A35 | Other tetanus |
| 0-9 | A-Z |
|---|---|
| A33 | Tetanus neonatorum |
| A34 | Obstetrical tetanus |
| A35 | Other tetanus |
| E80.21 | Acute intermittent (hepatic) porphyria |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| F31.1 | Bipolar disorder, current episode manic without psychotic features |
| F31.10 | Bipolar disorder, current episode manic without psychotic features, unspecified |
| F31.11 | Bipolar disorder, current episode manic without psychotic features, mild |
| F31.12 | Bipolar disorder, current episode manic without psychotic features, moderate |
| F31.13 | Bipolar disorder, current episode manic without psychotic features, severe |
| F31.2 | Bipolar disorder, current episode manic severe with psychotic features |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| R06.6 | Hiccough |
| R11 | Nausea and vomiting |
| R11.2 | Nausea with vomiting, unspecified |
Formulary Reference Tool